Mechanical Characterization of Vial Strain During Freezing and Thawing Operations Using Amorphous Excipients

The purpose of this study was to investigate the mechanical stresses and strains acting on pharmaceutical glass tubing vials during freezing and thawing of model pharmaceutical formulations. Strain measurements were conducted inside of a laboratory-scale freeze-dryer using a custom wireless sensor....

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Veröffentlicht in:	Journal of pharmaceutical sciences 2024-09, Vol.113 (9), p.2699-2707
Hauptverfasser:	Strongrich, Andrew, Flynn, Ian, Bhatnagar, Bakul, Shalaev, Evgenyi, Tchessalov, Serguei
Format:	Artikel
Sprache:	eng
Schlagworte:	Excipients Formulation Freeze-drying Glass transition(s) Mechanical properties Process analytical technology (PAT) Sucrose Trehalose Viscosity
Online-Zugang:	Volltext
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