Ido2 Deficiency Exacerbates Motor Impairment and Reduces Aryl Hydrocarbon Receptor Activity through Decreased Kynurenine in a Chronic Demyelinating Mouse Model

Demyelinating diseases including multiple sclerosis (MS) are chronic inflammatory diseases of the central nervous system. Indoleamine 2,3-dioxygenase 2 (Ido2) is a recently identified as catalytic enzyme involved in the rate-limiting step of the tryptophan-kynurenine pathway that influences suscepti...

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Veröffentlicht in:	Molecular neurobiology 2024-06
Hauptverfasser:	Kunisawa, Kazuo, Hara, Mitsuki, Yoshidomi, Koyo, Kon, Yuki, Yamamoto, Yasuko, Fujigaki, Suwako, Wulaer, Bolati, Kosuge, Aika, Tanabe, Moeka, Saitoh, Sei, Takahashi, Kazuo, Saito, Kuniaki, Nabeshima, Toshitaka, Mouri, Akihiro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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