Associations of an HDL apolipoproteomic index with cardiometabolic risk factors before and after exercise training in the HERITAGE Family Study
Previous studies have derived and validated an HDL apolipoproteomic score (pCAD) that predicts coronary artery disease (CAD) risk. However, the associations between pCAD and markers of cardiometabolic health in healthy adults are not known, nor are the effects of regular exercise on pCAD. A total of...
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| Veröffentlicht in: | Atherosclerosis 2024-08, Vol.395, p.117587, Article 117587 |
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| creator | Miranda Maravi, J. Sebastian Leszczynski, Eric C. Schwartz, Charles S. Dev, Prasun K. Barber, Jacob L. Reasons, Riley J. Pearce, Ryan W. McPhaul, Michael J. Konrad, Robert J. Robbins, Jeremy M. Gerszten, Robert E. Collier, Timothy S. Bouchard, Claude Rohatgi, Anand Sarzynski, Mark A. |
| description | Previous studies have derived and validated an HDL apolipoproteomic score (pCAD) that predicts coronary artery disease (CAD) risk. However, the associations between pCAD and markers of cardiometabolic health in healthy adults are not known, nor are the effects of regular exercise on pCAD.
A total of 641 physically inactive adults free of cardiovascular disease from the HERITAGE Family Study completed 20 weeks of exercise training. The pCAD index (range 0–100) was calculated using measurements of apolipoproteins A-I, C–I, C-II, C-III, and C-IV from ApoA-I-tagged serum (higher index = higher CAD risk). The associations between pCAD index and cardiometabolic traits at baseline and their training responses were assessed with Spearman correlation and general linear models. A Bonferroni correction of p |
| doi_str_mv | 10.1016/j.atherosclerosis.2024.117587 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3063472055</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021915024001473</els_id><sourcerecordid>3063472055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c259t-ddd6020ce9a791ac4672f559b140a1e2ac007ac66006f46d695bb0f8d4a750223</originalsourceid><addsrcrecordid>eNqNkU1vEzEQhi0EoqHwF5AvSFySjr3r_ThwiEqaVIqEBOVszdqz1GF3HWwHml_BX8ZRSg-cuNiXZ97ROw9j7wQsBIjqarfAdE_BRzOcXhcXEmS5EKJWTf2MzURTt3NRNuVzNgOQYt4KBRfsVYw7AChr0bxkF0XTyKJQxYz9XsbojcPk_BS57zlOfPNxy3HvB7f3--AT-dEZ7iZLD_yXS_fcYLDOj5Swy5DhwcXvvEeTfIi8o94HyjGWY58ocHqgYFwkngK6yU3fchTPFfhm9fn2brle8Rsc3XDkX9LBHl-zFz0Okd48_pfs683q7noz335a314vt3MjVZvm1toKJBhqsW4FmrKqZa9U24kSUJBEA1CjqSqAqi8rW7Wq66BvbIm1AimLS_b-nJsb_jhQTHp00dAw4ET-EHUBVVHWEpTK6IczavK9Y6Be74MbMRy1AH1yonf6Hyf65ESfneT5t4-rDt1I9mn6r4QMrM8A5cI_HQUdjaPJkHWBTNLWu_9c9QcqYakq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3063472055</pqid></control><display><type>article</type><title>Associations of an HDL apolipoproteomic index with cardiometabolic risk factors before and after exercise training in the HERITAGE Family Study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Miranda Maravi, J. Sebastian ; Leszczynski, Eric C. ; Schwartz, Charles S. ; Dev, Prasun K. ; Barber, Jacob L. ; Reasons, Riley J. ; Pearce, Ryan W. ; McPhaul, Michael J. ; Konrad, Robert J. ; Robbins, Jeremy M. ; Gerszten, Robert E. ; Collier, Timothy S. ; Bouchard, Claude ; Rohatgi, Anand ; Sarzynski, Mark A.</creator><creatorcontrib>Miranda Maravi, J. Sebastian ; Leszczynski, Eric C. ; Schwartz, Charles S. ; Dev, Prasun K. ; Barber, Jacob L. ; Reasons, Riley J. ; Pearce, Ryan W. ; McPhaul, Michael J. ; Konrad, Robert J. ; Robbins, Jeremy M. ; Gerszten, Robert E. ; Collier, Timothy S. ; Bouchard, Claude ; Rohatgi, Anand ; Sarzynski, Mark A.</creatorcontrib><description>Previous studies have derived and validated an HDL apolipoproteomic score (pCAD) that predicts coronary artery disease (CAD) risk. However, the associations between pCAD and markers of cardiometabolic health in healthy adults are not known, nor are the effects of regular exercise on pCAD.
A total of 641 physically inactive adults free of cardiovascular disease from the HERITAGE Family Study completed 20 weeks of exercise training. The pCAD index (range 0–100) was calculated using measurements of apolipoproteins A-I, C–I, C-II, C-III, and C-IV from ApoA-I-tagged serum (higher index = higher CAD risk). The associations between pCAD index and cardiometabolic traits at baseline and their training responses were assessed with Spearman correlation and general linear models. A Bonferroni correction of p < 8.9 × 10−04 was used to determine statistical significance.
The mean ± SD baseline pCAD index was 29 ± 32, with 106 (16.5 %) participants classified as high CAD risk. At baseline, pCAD index was positively associated with blood pressure, systemic inflammation, and body composition. HDL size, VO2max, and HDL-C were negatively associated with pCAD index at baseline. Of those classified as high CAD risk at baseline, 52 (49 %) were reclassified as normal risk after training. Following training, pCAD index changes were inversely correlated (p < 1.4 × 10−04) with changes in HDL-C, HDL size, and LDL size.
A higher pCAD index was associated with a worse cardiometabolic profile at baseline but improved with regular exercise. The results from this study highlight the potential role of HDL apolipoproteins as therapeutic targets for lifestyle interventions, particularly in high-risk individuals.
[Display omitted]
•A higher HDL apolipoproteomic index (pCAD) was associated with a worse cardiometabolic profile at baseline.•Individuals with the highest pCAD had the greatest reductions in pCAD following regular exercise.•HDL apolipoproteins are potential therapeutic targets for lifestyle interventions.</description><identifier>ISSN: 0021-9150</identifier><identifier>ISSN: 1879-1484</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2024.117587</identifier><identifier>PMID: 38823353</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Apolipoproteins - blood ; Biomarker ; Biomarkers - blood ; Cardiometabolic Risk Factors ; Cholesterol, HDL - blood ; Coronary artery disease ; Coronary Artery Disease - blood ; Exercise ; Exercise Therapy ; Female ; High-density lipoprotein ; Humans ; Lipoproteins, HDL - blood ; Male ; Middle Aged ; pCAD ; Proteomics ; Proteomics - methods ; Risk Assessment ; Sedentary Behavior ; Time Factors</subject><ispartof>Atherosclerosis, 2024-08, Vol.395, p.117587, Article 117587</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c259t-ddd6020ce9a791ac4672f559b140a1e2ac007ac66006f46d695bb0f8d4a750223</cites><orcidid>0000-0001-6705-0668</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915024001473$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38823353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miranda Maravi, J. Sebastian</creatorcontrib><creatorcontrib>Leszczynski, Eric C.</creatorcontrib><creatorcontrib>Schwartz, Charles S.</creatorcontrib><creatorcontrib>Dev, Prasun K.</creatorcontrib><creatorcontrib>Barber, Jacob L.</creatorcontrib><creatorcontrib>Reasons, Riley J.</creatorcontrib><creatorcontrib>Pearce, Ryan W.</creatorcontrib><creatorcontrib>McPhaul, Michael J.</creatorcontrib><creatorcontrib>Konrad, Robert J.</creatorcontrib><creatorcontrib>Robbins, Jeremy M.</creatorcontrib><creatorcontrib>Gerszten, Robert E.</creatorcontrib><creatorcontrib>Collier, Timothy S.</creatorcontrib><creatorcontrib>Bouchard, Claude</creatorcontrib><creatorcontrib>Rohatgi, Anand</creatorcontrib><creatorcontrib>Sarzynski, Mark A.</creatorcontrib><title>Associations of an HDL apolipoproteomic index with cardiometabolic risk factors before and after exercise training in the HERITAGE Family Study</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Previous studies have derived and validated an HDL apolipoproteomic score (pCAD) that predicts coronary artery disease (CAD) risk. However, the associations between pCAD and markers of cardiometabolic health in healthy adults are not known, nor are the effects of regular exercise on pCAD.
A total of 641 physically inactive adults free of cardiovascular disease from the HERITAGE Family Study completed 20 weeks of exercise training. The pCAD index (range 0–100) was calculated using measurements of apolipoproteins A-I, C–I, C-II, C-III, and C-IV from ApoA-I-tagged serum (higher index = higher CAD risk). The associations between pCAD index and cardiometabolic traits at baseline and their training responses were assessed with Spearman correlation and general linear models. A Bonferroni correction of p < 8.9 × 10−04 was used to determine statistical significance.
The mean ± SD baseline pCAD index was 29 ± 32, with 106 (16.5 %) participants classified as high CAD risk. At baseline, pCAD index was positively associated with blood pressure, systemic inflammation, and body composition. HDL size, VO2max, and HDL-C were negatively associated with pCAD index at baseline. Of those classified as high CAD risk at baseline, 52 (49 %) were reclassified as normal risk after training. Following training, pCAD index changes were inversely correlated (p < 1.4 × 10−04) with changes in HDL-C, HDL size, and LDL size.
A higher pCAD index was associated with a worse cardiometabolic profile at baseline but improved with regular exercise. The results from this study highlight the potential role of HDL apolipoproteins as therapeutic targets for lifestyle interventions, particularly in high-risk individuals.
[Display omitted]
•A higher HDL apolipoproteomic index (pCAD) was associated with a worse cardiometabolic profile at baseline.•Individuals with the highest pCAD had the greatest reductions in pCAD following regular exercise.•HDL apolipoproteins are potential therapeutic targets for lifestyle interventions.</description><subject>Adult</subject><subject>Apolipoproteins - blood</subject><subject>Biomarker</subject><subject>Biomarkers - blood</subject><subject>Cardiometabolic Risk Factors</subject><subject>Cholesterol, HDL - blood</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Exercise</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>High-density lipoprotein</subject><subject>Humans</subject><subject>Lipoproteins, HDL - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>pCAD</subject><subject>Proteomics</subject><subject>Proteomics - methods</subject><subject>Risk Assessment</subject><subject>Sedentary Behavior</subject><subject>Time Factors</subject><issn>0021-9150</issn><issn>1879-1484</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vEzEQhi0EoqHwF5AvSFySjr3r_ThwiEqaVIqEBOVszdqz1GF3HWwHml_BX8ZRSg-cuNiXZ97ROw9j7wQsBIjqarfAdE_BRzOcXhcXEmS5EKJWTf2MzURTt3NRNuVzNgOQYt4KBRfsVYw7AChr0bxkF0XTyKJQxYz9XsbojcPk_BS57zlOfPNxy3HvB7f3--AT-dEZ7iZLD_yXS_fcYLDOj5Swy5DhwcXvvEeTfIi8o94HyjGWY58ocHqgYFwkngK6yU3fchTPFfhm9fn2brle8Rsc3XDkX9LBHl-zFz0Okd48_pfs683q7noz335a314vt3MjVZvm1toKJBhqsW4FmrKqZa9U24kSUJBEA1CjqSqAqi8rW7Wq66BvbIm1AimLS_b-nJsb_jhQTHp00dAw4ET-EHUBVVHWEpTK6IczavK9Y6Be74MbMRy1AH1yonf6Hyf65ESfneT5t4-rDt1I9mn6r4QMrM8A5cI_HQUdjaPJkHWBTNLWu_9c9QcqYakq</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Miranda Maravi, J. 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Sebastian ; Leszczynski, Eric C. ; Schwartz, Charles S. ; Dev, Prasun K. ; Barber, Jacob L. ; Reasons, Riley J. ; Pearce, Ryan W. ; McPhaul, Michael J. ; Konrad, Robert J. ; Robbins, Jeremy M. ; Gerszten, Robert E. ; Collier, Timothy S. ; Bouchard, Claude ; Rohatgi, Anand ; Sarzynski, Mark A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-ddd6020ce9a791ac4672f559b140a1e2ac007ac66006f46d695bb0f8d4a750223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Apolipoproteins - blood</topic><topic>Biomarker</topic><topic>Biomarkers - blood</topic><topic>Cardiometabolic Risk Factors</topic><topic>Cholesterol, HDL - blood</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Exercise</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>High-density lipoprotein</topic><topic>Humans</topic><topic>Lipoproteins, HDL - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>pCAD</topic><topic>Proteomics</topic><topic>Proteomics - methods</topic><topic>Risk Assessment</topic><topic>Sedentary Behavior</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miranda Maravi, J. Sebastian</creatorcontrib><creatorcontrib>Leszczynski, Eric C.</creatorcontrib><creatorcontrib>Schwartz, Charles S.</creatorcontrib><creatorcontrib>Dev, Prasun K.</creatorcontrib><creatorcontrib>Barber, Jacob L.</creatorcontrib><creatorcontrib>Reasons, Riley J.</creatorcontrib><creatorcontrib>Pearce, Ryan W.</creatorcontrib><creatorcontrib>McPhaul, Michael J.</creatorcontrib><creatorcontrib>Konrad, Robert J.</creatorcontrib><creatorcontrib>Robbins, Jeremy M.</creatorcontrib><creatorcontrib>Gerszten, Robert E.</creatorcontrib><creatorcontrib>Collier, Timothy S.</creatorcontrib><creatorcontrib>Bouchard, Claude</creatorcontrib><creatorcontrib>Rohatgi, Anand</creatorcontrib><creatorcontrib>Sarzynski, Mark A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miranda Maravi, J. Sebastian</au><au>Leszczynski, Eric C.</au><au>Schwartz, Charles S.</au><au>Dev, Prasun K.</au><au>Barber, Jacob L.</au><au>Reasons, Riley J.</au><au>Pearce, Ryan W.</au><au>McPhaul, Michael J.</au><au>Konrad, Robert J.</au><au>Robbins, Jeremy M.</au><au>Gerszten, Robert E.</au><au>Collier, Timothy S.</au><au>Bouchard, Claude</au><au>Rohatgi, Anand</au><au>Sarzynski, Mark A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of an HDL apolipoproteomic index with cardiometabolic risk factors before and after exercise training in the HERITAGE Family Study</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2024-08</date><risdate>2024</risdate><volume>395</volume><spage>117587</spage><pages>117587-</pages><artnum>117587</artnum><issn>0021-9150</issn><issn>1879-1484</issn><eissn>1879-1484</eissn><abstract>Previous studies have derived and validated an HDL apolipoproteomic score (pCAD) that predicts coronary artery disease (CAD) risk. However, the associations between pCAD and markers of cardiometabolic health in healthy adults are not known, nor are the effects of regular exercise on pCAD.
A total of 641 physically inactive adults free of cardiovascular disease from the HERITAGE Family Study completed 20 weeks of exercise training. The pCAD index (range 0–100) was calculated using measurements of apolipoproteins A-I, C–I, C-II, C-III, and C-IV from ApoA-I-tagged serum (higher index = higher CAD risk). The associations between pCAD index and cardiometabolic traits at baseline and their training responses were assessed with Spearman correlation and general linear models. A Bonferroni correction of p < 8.9 × 10−04 was used to determine statistical significance.
The mean ± SD baseline pCAD index was 29 ± 32, with 106 (16.5 %) participants classified as high CAD risk. At baseline, pCAD index was positively associated with blood pressure, systemic inflammation, and body composition. HDL size, VO2max, and HDL-C were negatively associated with pCAD index at baseline. Of those classified as high CAD risk at baseline, 52 (49 %) were reclassified as normal risk after training. Following training, pCAD index changes were inversely correlated (p < 1.4 × 10−04) with changes in HDL-C, HDL size, and LDL size.
A higher pCAD index was associated with a worse cardiometabolic profile at baseline but improved with regular exercise. The results from this study highlight the potential role of HDL apolipoproteins as therapeutic targets for lifestyle interventions, particularly in high-risk individuals.
[Display omitted]
•A higher HDL apolipoproteomic index (pCAD) was associated with a worse cardiometabolic profile at baseline.•Individuals with the highest pCAD had the greatest reductions in pCAD following regular exercise.•HDL apolipoproteins are potential therapeutic targets for lifestyle interventions.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>38823353</pmid><doi>10.1016/j.atherosclerosis.2024.117587</doi><orcidid>https://orcid.org/0000-0001-6705-0668</orcidid></addata></record> |
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| subjects | Adult Apolipoproteins - blood Biomarker Biomarkers - blood Cardiometabolic Risk Factors Cholesterol, HDL - blood Coronary artery disease Coronary Artery Disease - blood Exercise Exercise Therapy Female High-density lipoprotein Humans Lipoproteins, HDL - blood Male Middle Aged pCAD Proteomics Proteomics - methods Risk Assessment Sedentary Behavior Time Factors |
| title | Associations of an HDL apolipoproteomic index with cardiometabolic risk factors before and after exercise training in the HERITAGE Family Study |
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