In Situ Synthesis of an Immune-Checkpoint Blocker from Engineered Bacteria Elicits a Potent Antitumor Response

Immune-checkpoint blockade (ICB) reinvigorates T cells from exhaustion and potentiates T-cell responses to tumors. However, most patients do not respond to ICB therapy, and only a limited response can be achieved in a “cold” tumor with few infiltrated lymphocytes. Synthetic biology can be used to en...

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Veröffentlicht in:	ACS synthetic biology 2024-06, Vol.13 (6), p.1679-1693
Hauptverfasser:	Wei, Yuting, Zhang, Zhirang, Xue, Tianyuan, Lin, Zhongda, Chen, Xinyu, Tian, Yishi, Li, Yuan, Jing, Zhangyan, Fang, Wenli, Fang, Tianliang, Li, Baoqi, Chen, Qi, Lan, Tianyu, Meng, Fanqiang, Zhang, Xudong, Liang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Hepatitis A Virus Cellular Receptor 2 - genetics Hepatitis A Virus Cellular Receptor 2 - metabolism Humans Immune Checkpoint Inhibitors - pharmacology Immunotherapy - methods Interferon-gamma - immunology Interferon-gamma - metabolism Mice Mice, Inbred C57BL Programmed Cell Death 1 Receptor - immunology Programmed Cell Death 1 Receptor - metabolism Salmonella - genetics Salmonella - immunology Single-Chain Antibodies - genetics Single-Chain Antibodies - immunology Single-Chain Antibodies - pharmacology Synthetic Biology - methods
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