Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization

A structure-based drug design approach was focused on incorporating phenyl ring heterocyclic bioisosteres into coumarin derivative 1, previously reported as potent dual AChE-MAO B inhibitor, with the aim of improving drug-like features. Structure-activity relationships highlighted that bioisosteric...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-08, Vol.274, p.116511, Article 116511
Hauptverfasser:	La Spada, Gabriella, Miniero, Daniela Valeria, Rullo, Mariagrazia, Cipolloni, Marco, Delre, Pietro, Colliva, Carolina, Colella, Marco, Leonetti, Francesco, Liuzzi, Grazia Maria, Mangiatordi, Giuseppe Felice, Giacchè, Nicola, Pisani, Leonardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Bioisostere Butyrylcholinesterase Monoamine oxidases Multitarget Structure-based
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