MicroProteinDB: A database to provide knowledge on sequences, structures and function of ncRNA-derived microproteins

Omics-based technologies have revolutionized our comprehension of microproteins encoded by ncRNAs, revealing their abundant presence and pivotal roles within complex functional landscapes. Here, we developed MicroProteinDB (http://bio-bigdata.hrbmu.edu.cn/MicroProteinDB), which offers and visualizes the extensive knowledge to aid retrieval and analysis of computationally predicted and experimentally validated microproteins originating from various ncRNA types. Employing prediction algorithms grounded in diverse deep learning approaches, MicroProteinDB comprehensively documents the fundamental physicochemical properties, secondary and tertiary structures, interactions with functional proteins, family domains, and inter-species conservation of microproteins. With five major analytical modules, it will serve as a valuable knowledge for investigating ncRNA-derived microproteins. •MicroProteinDB reanalyzed 51,095 ncRNA-derived microproteins across 15 cancer types and 31 non-cancerous tissues.•A comprehensive knowledge designed for the systematic presentation of sequences, structures, and functions of microproteins.•Five flexible tools and multiple visualization results have been developed within the MicroProteinDB platform.