Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

[Display omitted] The influence of hydroxypropyl cellulose type (HPC-SSL SFP, HPC-SSL), concentration (2 %, 3.5 %, 5 %) and filler (lactose, calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on twin-screw wet granulation and subsequent tableting was studied. The aim was to identify...

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Veröffentlicht in:	International journal of pharmaceutics 2024-06, Vol.659, p.124290, Article 124290
Hauptverfasser:	Köster, Claudia, Kleinebudde, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Binder Calcium Phosphates - chemistry Cellulose - analogs & derivatives Cellulose - chemistry Chemistry, Pharmaceutical - methods Drug Compounding - methods Excipients - chemistry Lactose - chemistry Pressure Solubility Tablet Tablet disintegration Tablet tensile strength Tablets Twin-screw granulation Wet granulation
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