20(R)-Panaxatriol enhances METTL3-mediated m6A modification of STUB1 to inhibit autophagy and exert antitumor effects in Triple-Negative Breast Cancer cells

Aberrant activation of autophagy in triple-negative breast cancer (TNBC) has led researchers to investigate potential therapeutic strategies targeting this process. The regulation of autophagy is significantly influenced by METTL3. Our previous research has shown that the Panax ginseng-derived compo...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-07, Vol.130, p.155537, Article 155537
Hauptverfasser:	Li, Yan, Luo, Bingjie, Lin, Xuan, Bai, Donghui, Li, Lingyu, Gao, Duan, Li, Xiaoyun, Zhong, Xianxun, Wei, Yaru, Yang, Li, Zhu, Xiaofeng, Han, Li, Tian, Huaqin, Zhang, Ronghua, Wang, Panpan
Format:	Artikel
Sprache:	eng
Schlagworte:	20(R)-panaxatriol antineoplastic agents Autophagy breast neoplasms fluorescent antibody technique half life histopathology methylation METTL3 N6-methyladenosine neoplasm cells pathogenesis reporter genes STUB1 therapeutics Triple negative breast cancer Western blotting
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