Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)
Alzheimer's disease (AD) is a progressive decline in cognitive ability and behavior which eventually disrupts daily activities. AD has no cure and the progression rate varies unlikely. Among various causative factors, heavy metals are reported to be a significant hazard in AD pathogenesis. Meta...
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Veröffentlicht in: | Journal of biochemical and molecular toxicology 2024-06, Vol.38 (6), p.e23741-n/a |
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creator | Venkatesan, Dhivya Muthukumar, Sindduja Iyer, Mahalaxmi Babu, Harysh Winster Suresh Gopalakrishnan, Abilash Valsala Yadav, Mukesh Kumar Vellingiri, Balachandar |
description | Alzheimer's disease (AD) is a progressive decline in cognitive ability and behavior which eventually disrupts daily activities. AD has no cure and the progression rate varies unlikely. Among various causative factors, heavy metals are reported to be a significant hazard in AD pathogenesis. Metal‐induced neurodegeneration has been focused globally with thorough research to unravel the mechanistic insights in AD. Recently, heavy metals suggested to play an important role in epigenetic alterations which might provide evidential results on AD pathology. Epigenetic modifications are known to play towards novel therapeutic approaches in treating AD. Though many studies focus on epigenetics and heavy metal implications in AD, there is a lack of research on heavy metal influence on epigenetic toxicity in neurological disorders. The current review aims to elucidate the plausible role of cadmium (Cd), iron (Fe), arsenic (As), copper (Cu), and lithium (Li) metals on epigenetic factors and the increase in amyloid beta and tau phosphorylation in AD. Also, the review discusses the common methods of heavy metal detection to implicate in AD pathogenesis. Hence, from this review, we can extend the need for future research on identifying the mechanistic behavior of heavy metals on epigenetic toxicity and to develop diagnostic and therapeutic markers in AD. |
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AD has no cure and the progression rate varies unlikely. Among various causative factors, heavy metals are reported to be a significant hazard in AD pathogenesis. Metal‐induced neurodegeneration has been focused globally with thorough research to unravel the mechanistic insights in AD. Recently, heavy metals suggested to play an important role in epigenetic alterations which might provide evidential results on AD pathology. Epigenetic modifications are known to play towards novel therapeutic approaches in treating AD. Though many studies focus on epigenetics and heavy metal implications in AD, there is a lack of research on heavy metal influence on epigenetic toxicity in neurological disorders. The current review aims to elucidate the plausible role of cadmium (Cd), iron (Fe), arsenic (As), copper (Cu), and lithium (Li) metals on epigenetic factors and the increase in amyloid beta and tau phosphorylation in AD. Also, the review discusses the common methods of heavy metal detection to implicate in AD pathogenesis. Hence, from this review, we can extend the need for future research on identifying the mechanistic behavior of heavy metals on epigenetic toxicity and to develop diagnostic and therapeutic markers in AD.</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.23741</identifier><identifier>PMID: 38816991</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Alzheimer Disease - chemically induced ; Alzheimer Disease - etiology ; Alzheimer Disease - genetics ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Alzheimer's disease (AD) ; Amyloid beta-Peptides - metabolism ; Animals ; Arsenic ; Cadmium ; Cognitive ability ; Copper ; Epigenesis, Genetic - drug effects ; epigenetic modifications ; Epigenetics ; Heavy metals ; Humans ; Iron ; Lithium ; Metals, Heavy - toxicity ; Neurodegenerative diseases ; Neurological diseases ; neurotoxicity ; Pathogenesis ; Phosphorylation ; Reviews ; Tau protein ; tau Proteins - genetics ; tau Proteins - metabolism ; therapeutic approach ; Toxicity</subject><ispartof>Journal of biochemical and molecular toxicology, 2024-06, Vol.38 (6), p.e23741-n/a</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2431-31879c6dea1873e1c49dd64b187110f8aa8fab44537e55d5894828a335f0fcfa3</cites><orcidid>0000-0003-0780-0492 ; 0000-0003-2672-6347</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.23741$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.23741$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38816991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venkatesan, Dhivya</creatorcontrib><creatorcontrib>Muthukumar, Sindduja</creatorcontrib><creatorcontrib>Iyer, Mahalaxmi</creatorcontrib><creatorcontrib>Babu, Harysh Winster Suresh</creatorcontrib><creatorcontrib>Gopalakrishnan, Abilash Valsala</creatorcontrib><creatorcontrib>Yadav, Mukesh Kumar</creatorcontrib><creatorcontrib>Vellingiri, Balachandar</creatorcontrib><title>Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J Biochem Mol Toxicol</addtitle><description>Alzheimer's disease (AD) is a progressive decline in cognitive ability and behavior which eventually disrupts daily activities. AD has no cure and the progression rate varies unlikely. Among various causative factors, heavy metals are reported to be a significant hazard in AD pathogenesis. Metal‐induced neurodegeneration has been focused globally with thorough research to unravel the mechanistic insights in AD. Recently, heavy metals suggested to play an important role in epigenetic alterations which might provide evidential results on AD pathology. Epigenetic modifications are known to play towards novel therapeutic approaches in treating AD. Though many studies focus on epigenetics and heavy metal implications in AD, there is a lack of research on heavy metal influence on epigenetic toxicity in neurological disorders. The current review aims to elucidate the plausible role of cadmium (Cd), iron (Fe), arsenic (As), copper (Cu), and lithium (Li) metals on epigenetic factors and the increase in amyloid beta and tau phosphorylation in AD. Also, the review discusses the common methods of heavy metal detection to implicate in AD pathogenesis. Hence, from this review, we can extend the need for future research on identifying the mechanistic behavior of heavy metals on epigenetic toxicity and to develop diagnostic and therapeutic markers in AD.</description><subject>Alzheimer Disease - chemically induced</subject><subject>Alzheimer Disease - etiology</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Alzheimer's disease (AD)</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Animals</subject><subject>Arsenic</subject><subject>Cadmium</subject><subject>Cognitive ability</subject><subject>Copper</subject><subject>Epigenesis, Genetic - drug effects</subject><subject>epigenetic modifications</subject><subject>Epigenetics</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Iron</subject><subject>Lithium</subject><subject>Metals, Heavy - toxicity</subject><subject>Neurodegenerative diseases</subject><subject>Neurological diseases</subject><subject>neurotoxicity</subject><subject>Pathogenesis</subject><subject>Phosphorylation</subject><subject>Reviews</subject><subject>Tau protein</subject><subject>tau Proteins - genetics</subject><subject>tau Proteins - metabolism</subject><subject>therapeutic approach</subject><subject>Toxicity</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlOwzAQQC0EYj_wA8gSB-CQYsdLnGPZQZW4wDlynTF1lcQldoHy9bgUOCBxmhnp6Wn0EDqgZEAJyc-m4zjIWcHpGtqmpCwzwiVd_9pFJmVBttBOCFNCiCgLsYm2mFJUliXdRvoW9OsCtxB1E3D07864uMC-wzBzz9BBdAa3vnbWGR2d7wJ2HY4TwDMdJ35JBBewt3jYfEzAtdAfB1y7ADoAPhlenu6hDZvcsP89d9HT9dXjxW02eri5uxiOMpNzRjNGVVEaWYNOCwNqeFnXko_TRSmxSmtl9ZhzwQoQohaq5CpXmjFhiTVWs110svLOev8yhxCr1gUDTaM78PNQMSJZysKVSujRH3Tq532XvltSUuZU5CRRpyvK9D6EHmw1612r-0VFSbXsXqXu1Vf3xB5-G-fjFupf8id0As5WwJtrYPG_qbo_f1wpPwG8Z4tY</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Venkatesan, Dhivya</creator><creator>Muthukumar, Sindduja</creator><creator>Iyer, Mahalaxmi</creator><creator>Babu, Harysh Winster Suresh</creator><creator>Gopalakrishnan, Abilash Valsala</creator><creator>Yadav, Mukesh Kumar</creator><creator>Vellingiri, Balachandar</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0780-0492</orcidid><orcidid>https://orcid.org/0000-0003-2672-6347</orcidid></search><sort><creationdate>202406</creationdate><title>Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)</title><author>Venkatesan, Dhivya ; Muthukumar, Sindduja ; Iyer, Mahalaxmi ; Babu, Harysh Winster Suresh ; Gopalakrishnan, Abilash Valsala ; Yadav, Mukesh Kumar ; Vellingiri, Balachandar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2431-31879c6dea1873e1c49dd64b187110f8aa8fab44537e55d5894828a335f0fcfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alzheimer Disease - chemically induced</topic><topic>Alzheimer Disease - etiology</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Alzheimer's disease (AD)</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Animals</topic><topic>Arsenic</topic><topic>Cadmium</topic><topic>Cognitive ability</topic><topic>Copper</topic><topic>Epigenesis, Genetic - drug effects</topic><topic>epigenetic modifications</topic><topic>Epigenetics</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Iron</topic><topic>Lithium</topic><topic>Metals, Heavy - toxicity</topic><topic>Neurodegenerative diseases</topic><topic>Neurological diseases</topic><topic>neurotoxicity</topic><topic>Pathogenesis</topic><topic>Phosphorylation</topic><topic>Reviews</topic><topic>Tau protein</topic><topic>tau Proteins - genetics</topic><topic>tau Proteins - metabolism</topic><topic>therapeutic approach</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Venkatesan, Dhivya</creatorcontrib><creatorcontrib>Muthukumar, Sindduja</creatorcontrib><creatorcontrib>Iyer, Mahalaxmi</creatorcontrib><creatorcontrib>Babu, Harysh Winster Suresh</creatorcontrib><creatorcontrib>Gopalakrishnan, Abilash Valsala</creatorcontrib><creatorcontrib>Yadav, Mukesh Kumar</creatorcontrib><creatorcontrib>Vellingiri, Balachandar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Venkatesan, Dhivya</au><au>Muthukumar, Sindduja</au><au>Iyer, Mahalaxmi</au><au>Babu, Harysh Winster Suresh</au><au>Gopalakrishnan, Abilash Valsala</au><au>Yadav, Mukesh Kumar</au><au>Vellingiri, Balachandar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J Biochem Mol Toxicol</addtitle><date>2024-06</date><risdate>2024</risdate><volume>38</volume><issue>6</issue><spage>e23741</spage><epage>n/a</epage><pages>e23741-n/a</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><abstract>Alzheimer's disease (AD) is a progressive decline in cognitive ability and behavior which eventually disrupts daily activities. AD has no cure and the progression rate varies unlikely. Among various causative factors, heavy metals are reported to be a significant hazard in AD pathogenesis. Metal‐induced neurodegeneration has been focused globally with thorough research to unravel the mechanistic insights in AD. Recently, heavy metals suggested to play an important role in epigenetic alterations which might provide evidential results on AD pathology. Epigenetic modifications are known to play towards novel therapeutic approaches in treating AD. Though many studies focus on epigenetics and heavy metal implications in AD, there is a lack of research on heavy metal influence on epigenetic toxicity in neurological disorders. The current review aims to elucidate the plausible role of cadmium (Cd), iron (Fe), arsenic (As), copper (Cu), and lithium (Li) metals on epigenetic factors and the increase in amyloid beta and tau phosphorylation in AD. Also, the review discusses the common methods of heavy metal detection to implicate in AD pathogenesis. Hence, from this review, we can extend the need for future research on identifying the mechanistic behavior of heavy metals on epigenetic toxicity and to develop diagnostic and therapeutic markers in AD.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38816991</pmid><doi>10.1002/jbt.23741</doi><tpages>25</tpages><orcidid>https://orcid.org/0000-0003-0780-0492</orcidid><orcidid>https://orcid.org/0000-0003-2672-6347</orcidid></addata></record> |
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subjects | Alzheimer Disease - chemically induced Alzheimer Disease - etiology Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Alzheimer's disease (AD) Amyloid beta-Peptides - metabolism Animals Arsenic Cadmium Cognitive ability Copper Epigenesis, Genetic - drug effects epigenetic modifications Epigenetics Heavy metals Humans Iron Lithium Metals, Heavy - toxicity Neurodegenerative diseases Neurological diseases neurotoxicity Pathogenesis Phosphorylation Reviews Tau protein tau Proteins - genetics tau Proteins - metabolism therapeutic approach Toxicity |
title | Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD) |
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