Glyburide confers neuroprotection against age-related macular degeneration (AMD)

Glyburide, a sulfonylurea drug used to treat type 2 diabetes, boasts neuroprotective effects by targeting the sulfonylurea receptor 1 (SUR1) and associated ion channels in various cell types, including those in the central nervous system and the retina. Previously, we demonstrated that glyburide the...

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Veröffentlicht in:	Translational research : the journal of laboratory and clinical medicine 2024-10, Vol.272, p.81-94
Hauptverfasser:	Picard, Emilie, Youale, Jenny, Hyman, Max J., Xie, Edward, Achiedo, Seiki, Kaufmann, Gabriel T., Moir, John, Daruich, Alejandra, Crisanti, Patricia, Torriglia, Alicia, Polak, Michel, Behar-Cohen, Francine, Skondra, Dimitra, Berdugo, Marianne
Format:	Artikel
Sprache:	eng
Schlagworte:	Age-related macular degeneration (AMD) Dry AMD Glibenclamide Glyburide photoreceptors retinal apoptosis retinal degeneration Retinal neuroprotection retinal oxidative stress Sulfonylurea Sulfonylurea Receptor-1 (SUR1)
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