Wogonin ameliorates ER stress-associated inflammatory response, apoptotic death and renal fibrosis in a unilateral ureteral obstruction mouse model

Wogonin, a vital bioactive compound extracted from the medicinal plant, Scutellaria baicalensis, has been wildly used for its potential in mitigating the progression of chronic diseases. Chronic kidney disease (CKD) represents a significant global health challenge due to its high prevalence, morbidi...

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Veröffentlicht in:	European journal of pharmacology 2024-08, Vol.977, p.176676, Article 176676
Hauptverfasser:	Kuo, Huey-Liang, Chuang, Haw-Ling, Chen, Chang-Mu, Chen, Yu-Ya, Chen, Yu-Syuan, Lin, Ssu-Chia, Weng, Pei-Yu, Liu, Ting-Chun, Wang, Pei-Yun, Huang, Chun-Fa, Guan, Siao-Syun, Liu, Shing-Hwa, Yang, Shun-Fa, Wu, Cheng-Tien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell Line Chronic kidney disease Disease Models, Animal Endoplasmic Reticulum Chaperone BiP Endoplasmic Reticulum Stress - drug effects ER stress Fibrosis Flavanones - pharmacology Flavanones - therapeutic use Inflammation Inflammation - drug therapy Inflammation - pathology Kidney - drug effects Kidney - metabolism Kidney - pathology Male Mice Mice, Inbred C57BL Rats Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - pathology Transforming Growth Factor beta - metabolism Ureteral Obstruction - complications Ureteral Obstruction - drug therapy Ureteral Obstruction - pathology Wogonin
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