Geographic EBV variants confound disease-specific variant interpretation and predict variable immune therapy responses

•Geography, rather than disease, has a greater influence on genome-wide EBV variation.•Variation in EBV genomes predicts altered viral peptide binding to major histocompatibility complex, necessitating tailored vaccine and cellular therapy strategies. [Display omitted] Epstein-Barr virus (EBV) is a...

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Veröffentlicht in:	Blood advances 2024-07, Vol.8 (14), p.3731-3744
Hauptverfasser:	Briercheck, Edward L., Ravishankar, Shashidhar, Ahmed, Elshafa Hassan, Carías Alvarado, César Camilo, Barrios Menéndez, Juan Carlos, Silva, Oscar, Solórzano-Ortiz, Elizabeth, Siliézar Tala, Marcos Mauricio, Stevenson, Philip, Xu, Yuexin, Wohns, Anthony Wilder, Enriquez-Vera, Daniel, Barrionuevo, Carlos, Yu, Shan-Chi, Freud, Aharon G., Oakes, Christopher, Weigel, Christoph, Weinstock, David M., Klimaszewski, Haley L., Ngankeu, Apollinaire, Mutalima, Nora, Samayoa-Reyes, Gabriela, Newton, Robert, Rochford, Rosemary, Valvert, Fabiola, Natkunam, Yasodha, Shustov, Andrei, Baiocchi, Robert A., Warren, Edus H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Epstein-Barr Virus Infections - immunology Genetic Variation Genome, Viral Herpesvirus 4, Human - genetics Humans Immunotherapy
Online-Zugang:	Volltext
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