Unusual case of extramammary Paget disease of the oral mucosa: A case report and literature review
Paget disease is an intraepithelial neoplastic proliferation, commonly occurring in the breast and apocrine‐rich areas, often associated with an underlying internal malignancy. Extramammary Paget disease (EMPD) of the oral cavity is exceedingly rare, with only eight reported cases, four of which wer...
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| Veröffentlicht in: | Journal of cutaneous pathology 2024-09, Vol.51 (9), p.666-671 |
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| container_title | Journal of cutaneous pathology |
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| creator | Eilers, Grant Jordan, Richard C. |
| description | Paget disease is an intraepithelial neoplastic proliferation, commonly occurring in the breast and apocrine‐rich areas, often associated with an underlying internal malignancy. Extramammary Paget disease (EMPD) of the oral cavity is exceedingly rare, with only eight reported cases, four of which were associated with an underlying internal malignancy. Here, we report a case of oral EMPD involving the buccal mucosa and gingiva of an 81‐year‐old male with no known underlying internal malignancy. The Paget cells were positive for CK7, CK20, CAM5.2, and androgen receptor, but negative for SOX10 and p63. The immunophenotype, association with internal malignancies, and treatment approaches for oral EMPD are reviewed. |
| doi_str_mv | 10.1111/cup.14663 |
| format | Article |
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Extramammary Paget disease (EMPD) of the oral cavity is exceedingly rare, with only eight reported cases, four of which were associated with an underlying internal malignancy. Here, we report a case of oral EMPD involving the buccal mucosa and gingiva of an 81‐year‐old male with no known underlying internal malignancy. The Paget cells were positive for CK7, CK20, CAM5.2, and androgen receptor, but negative for SOX10 and p63. 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Extramammary Paget disease (EMPD) of the oral cavity is exceedingly rare, with only eight reported cases, four of which were associated with an underlying internal malignancy. Here, we report a case of oral EMPD involving the buccal mucosa and gingiva of an 81‐year‐old male with no known underlying internal malignancy. The Paget cells were positive for CK7, CK20, CAM5.2, and androgen receptor, but negative for SOX10 and p63. The immunophenotype, association with internal malignancies, and treatment approaches for oral EMPD are reviewed.</description><subject>Androgen receptors</subject><subject>Buccal mucosa</subject><subject>candidiasis, oral</subject><subject>Case reports</subject><subject>lichen planus, oral</subject><subject>Literature reviews</subject><subject>Malignancy</subject><subject>Oral cavity</subject><subject>Paget disease, extramammary</subject><subject>salivary gland neoplasms</subject><subject>Sox10 protein</subject><subject>surgery, oral</subject><issn>0303-6987</issn><issn>1600-0560</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kMtOwzAQRS0EoqWw4AdQJDawSOtHYifsqoqXhEQXdB2NHQdS5VHsmNK_xyGFBRLejOQ5czVzEDoneEr8mym3mZKIc3aAxoRjHOKY40M0xgyzkKeJGKETa9cYE57w-BiNWJIQSmM6RnLVOOugChRYHbRFoD87AzXUNZhdsIRX3QV5afW-2735YjxeO9VauAnmw6DRm9Z0ATR5UJWdNtA50_9-lHp7io4KqKw-29cJWt3dviwewqfn-8fF_ClUVCQsFP6SSEIaCZbmkMdA0rSItYoiKngkI78ulzgqJMgUlGIxpYTGIFKJhaScsAm6GnI3pn132nZZXVqlqwoa3TqbMcxpzChNevTyD7punWn8dp5KBMEpocJT1wOlTGut0UW2MWXvJSM468VnXnz2Ld6zF_tEJ2ud_5I_pj0wG4BtWend_0nZYrUcIr8Ar1yLQg</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Eilers, Grant</creator><creator>Jordan, Richard C.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9191-5932</orcidid></search><sort><creationdate>202409</creationdate><title>Unusual case of extramammary Paget disease of the oral mucosa: A case report and literature review</title><author>Eilers, Grant ; Jordan, Richard C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2783-71114ba94739dad5a199f5ec442764b42526b04fbab9acc3522125a79b07b2613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Androgen receptors</topic><topic>Buccal mucosa</topic><topic>candidiasis, oral</topic><topic>Case reports</topic><topic>lichen planus, oral</topic><topic>Literature reviews</topic><topic>Malignancy</topic><topic>Oral cavity</topic><topic>Paget disease, extramammary</topic><topic>salivary gland neoplasms</topic><topic>Sox10 protein</topic><topic>surgery, oral</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eilers, Grant</creatorcontrib><creatorcontrib>Jordan, Richard C.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eilers, Grant</au><au>Jordan, Richard C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unusual case of extramammary Paget disease of the oral mucosa: A case report and literature review</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2024-09</date><risdate>2024</risdate><volume>51</volume><issue>9</issue><spage>666</spage><epage>671</epage><pages>666-671</pages><issn>0303-6987</issn><issn>1600-0560</issn><eissn>1600-0560</eissn><abstract>Paget disease is an intraepithelial neoplastic proliferation, commonly occurring in the breast and apocrine‐rich areas, often associated with an underlying internal malignancy. 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| ispartof | Journal of cutaneous pathology, 2024-09, Vol.51 (9), p.666-671 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Androgen receptors Buccal mucosa candidiasis, oral Case reports lichen planus, oral Literature reviews Malignancy Oral cavity Paget disease, extramammary salivary gland neoplasms Sox10 protein surgery, oral |
| title | Unusual case of extramammary Paget disease of the oral mucosa: A case report and literature review |
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