In vitro evaluation of the percutaneous absorption of progesterone in anhydrous permeation-enhancing base using the Franz skin finite dose model and mass spectrometry
Progesterone is used for hormone replacement therapy through various routes of administration. This study was conducted to (a) evaluate the stability of progesterone in a proprietary anhydrous permeation-enhancing base (APEB) and the efficiency of its skin permeation, and (b) determine the appropria...
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| Veröffentlicht in: | Archives of dermatological research 2024-05, Vol.316 (6), p.291, Article 291 |
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| creator | Banov, Daniel Song, Guiyun Ip, Kendice Seeley, Erin H. Linehan, Stefan T. Bassani, Isabel Ferron, Gianna Bassani, August S. Valdez, Benigno C. |
| description | Progesterone is used for hormone replacement therapy through various routes of administration. This study was conducted to (a) evaluate the stability of progesterone in a proprietary anhydrous permeation-enhancing base (APEB) and the efficiency of its skin permeation, and (b) determine the appropriateness of mass spectrometry as a method of analysis for permeated progesterone. Using a proven stability-indicating ultra-performance liquid chromatographic method, the compounded hormone (100 mg progesterone/g APEB gel) was determined to be physically and chemically stable at room temperature for six months. Skin permeation analysis using the Franz skin finite dose model and mass spectrometry imaging showed an optical density of 1699 for the permeated progesterone compounded in APEB and 550 for the permeated progesterone in a water containing VBC, which is a statistically significant different (
P
= 0.029). The study suggests that APEB can be used as a compounding base for effective skin permeation of progesterone, and mass spectrometry is a reliable method for visualization and quantitative analysis of permeated progesterone. |
| doi_str_mv | 10.1007/s00403-024-03040-x |
| format | Article |
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P
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P
= 0.029). The study suggests that APEB can be used as a compounding base for effective skin permeation of progesterone, and mass spectrometry is a reliable method for visualization and quantitative analysis of permeated progesterone.</description><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Dermatology</subject><subject>Drug Compounding - methods</subject><subject>Drug Stability</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Mass spectroscopy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Optical density</subject><subject>Original Paper</subject><subject>Permeability</subject><subject>Progesterone</subject><subject>Progesterone - administration & dosage</subject><subject>Progesterone - metabolism</subject><subject>Progesterone - pharmacokinetics</subject><subject>Scientific imaging</subject><subject>Skin</subject><subject>Skin - metabolism</subject><subject>Skin Absorption - drug effects</subject><subject>Statistical analysis</subject><issn>1432-069X</issn><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kctu1TAURS0EoqXlBxggS0yYhB4_8hqiqoVKlTopUmeWHyf3piR2sJOqlw_iO_FtWkAdMPKWvPb2Od6EvGPwiQHUJwlAgiiAywJElsX9C3LIpOAFVO3Ny3_0AXmT0i1kU92w1-RANA2TsqkOya8LT-_6OQaKd3pY9NwHT0NH5y3SCaNdZu0xLIlqk0Kcnq6nGDaYZozBI-091X67c3HPZdOIDzEF-q32tvcbanRCuqS93AefR-1_0vQ9G7ve9zNSFzIwBodDjnJ01CnRNKHNg404x90xedXpIeHbx_OIfDs_uz79Wlxefbk4_XxZWAEwF9Ya5wxIVgGUwLqOVVw31kngFTPCQW2c1NrwkgkGRvKqbVpRZ4l1VYIUR-TjmpsX_LHkDdXYJ4vDsP6CElDxkjdtWWb0wzP0NizR5-kyVfO6FrxtMsVXysaQUsROTbEfddwpBmrfolpbVLlF9dCius-m94_RixnR_bE81ZYBsQIpX_kNxr9v_yf2N5-Wq7g</recordid><startdate>20240530</startdate><enddate>20240530</enddate><creator>Banov, Daniel</creator><creator>Song, Guiyun</creator><creator>Ip, Kendice</creator><creator>Seeley, Erin H.</creator><creator>Linehan, Stefan T.</creator><creator>Bassani, Isabel</creator><creator>Ferron, Gianna</creator><creator>Bassani, August S.</creator><creator>Valdez, Benigno C.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240530</creationdate><title>In vitro evaluation of the percutaneous absorption of progesterone in anhydrous permeation-enhancing base using the Franz skin finite dose model and mass spectrometry</title><author>Banov, Daniel ; Song, Guiyun ; Ip, Kendice ; Seeley, Erin H. ; Linehan, Stefan T. ; Bassani, Isabel ; Ferron, Gianna ; Bassani, August S. ; Valdez, Benigno C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-ccbddb041600501ff162a8cd40261b3d07bd4aab251310b4269893710be765043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Dermatology</topic><topic>Drug Compounding - methods</topic><topic>Drug Stability</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>Mass spectroscopy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Optical density</topic><topic>Original Paper</topic><topic>Permeability</topic><topic>Progesterone</topic><topic>Progesterone - administration & dosage</topic><topic>Progesterone - metabolism</topic><topic>Progesterone - pharmacokinetics</topic><topic>Scientific imaging</topic><topic>Skin</topic><topic>Skin - metabolism</topic><topic>Skin Absorption - drug effects</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banov, Daniel</creatorcontrib><creatorcontrib>Song, Guiyun</creatorcontrib><creatorcontrib>Ip, Kendice</creatorcontrib><creatorcontrib>Seeley, Erin H.</creatorcontrib><creatorcontrib>Linehan, Stefan T.</creatorcontrib><creatorcontrib>Bassani, Isabel</creatorcontrib><creatorcontrib>Ferron, Gianna</creatorcontrib><creatorcontrib>Bassani, August S.</creatorcontrib><creatorcontrib>Valdez, Benigno C.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banov, Daniel</au><au>Song, Guiyun</au><au>Ip, Kendice</au><au>Seeley, Erin H.</au><au>Linehan, Stefan T.</au><au>Bassani, Isabel</au><au>Ferron, Gianna</au><au>Bassani, August S.</au><au>Valdez, Benigno C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro evaluation of the percutaneous absorption of progesterone in anhydrous permeation-enhancing base using the Franz skin finite dose model and mass spectrometry</atitle><jtitle>Archives of dermatological research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2024-05-30</date><risdate>2024</risdate><volume>316</volume><issue>6</issue><spage>291</spage><pages>291-</pages><artnum>291</artnum><issn>1432-069X</issn><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Progesterone is used for hormone replacement therapy through various routes of administration. This study was conducted to (a) evaluate the stability of progesterone in a proprietary anhydrous permeation-enhancing base (APEB) and the efficiency of its skin permeation, and (b) determine the appropriateness of mass spectrometry as a method of analysis for permeated progesterone. Using a proven stability-indicating ultra-performance liquid chromatographic method, the compounded hormone (100 mg progesterone/g APEB gel) was determined to be physically and chemically stable at room temperature for six months. Skin permeation analysis using the Franz skin finite dose model and mass spectrometry imaging showed an optical density of 1699 for the permeated progesterone compounded in APEB and 550 for the permeated progesterone in a water containing VBC, which is a statistically significant different (
P
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| ispartof | Archives of dermatological research, 2024-05, Vol.316 (6), p.291, Article 291 |
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| subjects | Administration, Cutaneous Animals Chromatography, High Pressure Liquid - methods Dermatology Drug Compounding - methods Drug Stability Hormone replacement therapy Humans Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Medicine Medicine & Public Health Optical density Original Paper Permeability Progesterone Progesterone - administration & dosage Progesterone - metabolism Progesterone - pharmacokinetics Scientific imaging Skin Skin - metabolism Skin Absorption - drug effects Statistical analysis |
| title | In vitro evaluation of the percutaneous absorption of progesterone in anhydrous permeation-enhancing base using the Franz skin finite dose model and mass spectrometry |
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