Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1

Generally shortened 3′ UTR due to alternative polyadenylation (APA) is widely observed in cancer, but its regulation mechanisms for cancer are not well characterized. Here, with profiling of APA in colorectal cancer tissues and poly(A) signal editing, we firstly identified that the shortened 3′ UTR...

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Veröffentlicht in:	Science China. Life sciences 2024-06, Vol.67 (6), p.1212-1225
Hauptverfasser:	Hu, Zhijie, Li, Mengxia, Chen, Yufeng, Chen, Liutao, Han, Yuting, Chen, Chengyong, Lu, Xin, You, Nan, Lou, Yawen, Huang, Yingye, Huo, Zhanfeng, Liu, Chao, Liang, Cheng, Liu, Susu, Deng, Ke, Chen, Liangfu, Chen, Shangwu, Wan, Guohui, Wu, Xiaojian, Fu, Yonggui, Xu, Anlong
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Biomedical and Life Sciences Cancer Cell growth Cell migration Cell proliferation Colorectal cancer Colorectal carcinoma Life Sciences Polyadenylation Reseach Paper Splicing factors
Online-Zugang:	Volltext
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