Microbiota-induced inflammatory responses in bladder tumors promote epithelial-mesenchymal transition and enhanced immune infiltration

The intratumoral microbiota can modulate the tumor immune microenvironment (TIME); however, the underlying mechanism by which intratumoral microbiota influences the TIME in urothelial carcinoma of the bladder (UCB) remains unclear. To address this, we collected samples from 402 patients with UCB, in...

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Veröffentlicht in:	Physiological genomics 2024-08, Vol.56 (8), p.544-554
Hauptverfasser:	Li, Qiang, Sun, Yichao, Zhai, Kun, Geng, Bingzhi, Dong, Zhenkun, Ji, Lei, Chen, Hui, Cui, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bladder Clostridiales - genetics Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic Humans Immunotherapy Immunotherapy - methods Infiltration Inflammation Inflammation - immunology Inflammation - microbiology Male Metastases Microbiomes Microbiota Microenvironments Middle Aged Transcriptome - genetics Transcriptomes Tumor Microenvironment - immunology Tumors Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - microbiology Urinary Bladder Neoplasms - pathology Urothelial carcinoma
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