Microbiota-induced inflammatory responses in bladder tumors promote epithelial-mesenchymal transition and enhanced immune infiltration
The intratumoral microbiota can modulate the tumor immune microenvironment (TIME); however, the underlying mechanism by which intratumoral microbiota influences the TIME in urothelial carcinoma of the bladder (UCB) remains unclear. To address this, we collected samples from 402 patients with UCB, in...
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Veröffentlicht in: | Physiological genomics 2024-08, Vol.56 (8), p.544-554 |
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description | The intratumoral microbiota can modulate the tumor immune microenvironment (TIME); however, the underlying mechanism by which intratumoral microbiota influences the TIME in urothelial carcinoma of the bladder (UCB) remains unclear. To address this, we collected samples from 402 patients with UCB, including paired host transcriptome and tumor microbiome data, from The Cancer Genome Atlas (TCGA). We found that the intratumoral microbiome profiles were significantly correlated with the expression pattern of epithelial-mesenchymal transition (EMT)-related genes. Furthermore, we detected that the genera
and
in tumors could indirectly promote the EMT program by inducing an inflammatory response. Moreover, the inflammatory response induced by these two intratumoral bacteria further enhanced intratumoral immune infiltration, affecting patient survival and response to immunotherapy. In addition, an independent immunotherapy cohort of 348 patients with bladder cancer was used to validate our results. Collectively, our study elucidates the potential mechanism by which the intratumoral microbiota influences the TIME of UCB and provides a new guiding strategy for the targeted therapy of UCB.
The intratumoral microbiota may mediate the bladder tumor inflammatory response, thereby promoting the epithelial-mesenchymal transition program and influencing tumor immune infiltration. |
doi_str_mv | 10.1152/physiolgenomics.00032.2024 |
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and
in tumors could indirectly promote the EMT program by inducing an inflammatory response. Moreover, the inflammatory response induced by these two intratumoral bacteria further enhanced intratumoral immune infiltration, affecting patient survival and response to immunotherapy. In addition, an independent immunotherapy cohort of 348 patients with bladder cancer was used to validate our results. Collectively, our study elucidates the potential mechanism by which the intratumoral microbiota influences the TIME of UCB and provides a new guiding strategy for the targeted therapy of UCB.
The intratumoral microbiota may mediate the bladder tumor inflammatory response, thereby promoting the epithelial-mesenchymal transition program and influencing tumor immune infiltration.</description><identifier>ISSN: 1094-8341</identifier><identifier>ISSN: 1531-2267</identifier><identifier>EISSN: 1531-2267</identifier><identifier>DOI: 10.1152/physiolgenomics.00032.2024</identifier><identifier>PMID: 38808774</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Bladder ; Clostridiales - genetics ; Epithelial-Mesenchymal Transition - genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunotherapy ; Immunotherapy - methods ; Infiltration ; Inflammation ; Inflammation - immunology ; Inflammation - microbiology ; Male ; Metastases ; Microbiomes ; Microbiota ; Microenvironments ; Middle Aged ; Transcriptome - genetics ; Transcriptomes ; Tumor Microenvironment - immunology ; Tumors ; Urinary Bladder Neoplasms - genetics ; Urinary Bladder Neoplasms - immunology ; Urinary Bladder Neoplasms - microbiology ; Urinary Bladder Neoplasms - pathology ; Urothelial carcinoma</subject><ispartof>Physiological genomics, 2024-08, Vol.56 (8), p.544-554</ispartof><rights>Copyright American Physiological Society Aug 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c220t-7d8a7ee2544d22355233d14344fd46b2c56aa58ba646b55f920a524ddc5b9a593</cites><orcidid>0009-0007-0536-0063</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,3041,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38808774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Sun, Yichao</creatorcontrib><creatorcontrib>Zhai, Kun</creatorcontrib><creatorcontrib>Geng, Bingzhi</creatorcontrib><creatorcontrib>Dong, Zhenkun</creatorcontrib><creatorcontrib>Ji, Lei</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Cui, Yan</creatorcontrib><title>Microbiota-induced inflammatory responses in bladder tumors promote epithelial-mesenchymal transition and enhanced immune infiltration</title><title>Physiological genomics</title><addtitle>Physiol Genomics</addtitle><description>The intratumoral microbiota can modulate the tumor immune microenvironment (TIME); however, the underlying mechanism by which intratumoral microbiota influences the TIME in urothelial carcinoma of the bladder (UCB) remains unclear. To address this, we collected samples from 402 patients with UCB, including paired host transcriptome and tumor microbiome data, from The Cancer Genome Atlas (TCGA). We found that the intratumoral microbiome profiles were significantly correlated with the expression pattern of epithelial-mesenchymal transition (EMT)-related genes. Furthermore, we detected that the genera
and
in tumors could indirectly promote the EMT program by inducing an inflammatory response. Moreover, the inflammatory response induced by these two intratumoral bacteria further enhanced intratumoral immune infiltration, affecting patient survival and response to immunotherapy. In addition, an independent immunotherapy cohort of 348 patients with bladder cancer was used to validate our results. Collectively, our study elucidates the potential mechanism by which the intratumoral microbiota influences the TIME of UCB and provides a new guiding strategy for the targeted therapy of UCB.
The intratumoral microbiota may mediate the bladder tumor inflammatory response, thereby promoting the epithelial-mesenchymal transition program and influencing tumor immune infiltration.</description><subject>Bladder</subject><subject>Clostridiales - genetics</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Infiltration</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Inflammation - microbiology</subject><subject>Male</subject><subject>Metastases</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microenvironments</subject><subject>Middle Aged</subject><subject>Transcriptome - genetics</subject><subject>Transcriptomes</subject><subject>Tumor Microenvironment - immunology</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary Bladder Neoplasms - immunology</subject><subject>Urinary Bladder Neoplasms - microbiology</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urothelial carcinoma</subject><issn>1094-8341</issn><issn>1531-2267</issn><issn>1531-2267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcluFDEQQC0EIgv8ArLgwqUHr9093FAEBCmIC5yt6nY148hLY7sP8wP5bjxJ4JCTy6VXi-oR8pazHedafFgPx-KS_40xBTeXHWNMip1gQj0j51xL3gnRD89bzPaqG6XiZ-SilFvGuBpG_ZKcyXFk4zCoc3L33c05TS5V6Fy024yWurh4CAFqykeasawpFiwtTScP1mKmdQspF7rmFFJFiqurB_QOfBewYJwPxwCe1gyxuOpSpBAtxXiAeN8_hC3iaYzzjTkBr8iLBXzB14_vJfn15fPPq-vu5sfXb1efbrpZCFa7wY4wIAqtlBVCai2ktFxJpRar-knMugfQ4wR9-2m97AUDLZS1s572oPfykrx_6NtW_7NhqSa4MqP3EDFtxUjW82FUvOcNffcEvU1bjm07IznTmgupRKM-PlDtiqVkXMyaXYB8NJyZky3zxJa5t2VOtlrxm8cR2xTQ_i_9p0f-BbiUmWU</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Li, Qiang</creator><creator>Sun, Yichao</creator><creator>Zhai, Kun</creator><creator>Geng, Bingzhi</creator><creator>Dong, Zhenkun</creator><creator>Ji, Lei</creator><creator>Chen, Hui</creator><creator>Cui, Yan</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0007-0536-0063</orcidid></search><sort><creationdate>20240801</creationdate><title>Microbiota-induced inflammatory responses in bladder tumors promote epithelial-mesenchymal transition and enhanced immune infiltration</title><author>Li, Qiang ; Sun, Yichao ; Zhai, Kun ; Geng, Bingzhi ; Dong, Zhenkun ; Ji, Lei ; Chen, Hui ; Cui, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c220t-7d8a7ee2544d22355233d14344fd46b2c56aa58ba646b55f920a524ddc5b9a593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Bladder</topic><topic>Clostridiales - genetics</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Immunotherapy - methods</topic><topic>Infiltration</topic><topic>Inflammation</topic><topic>Inflammation - immunology</topic><topic>Inflammation - microbiology</topic><topic>Male</topic><topic>Metastases</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microenvironments</topic><topic>Middle Aged</topic><topic>Transcriptome - genetics</topic><topic>Transcriptomes</topic><topic>Tumor Microenvironment - immunology</topic><topic>Tumors</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urinary Bladder Neoplasms - immunology</topic><topic>Urinary Bladder Neoplasms - microbiology</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urothelial carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Qiang</creatorcontrib><creatorcontrib>Sun, Yichao</creatorcontrib><creatorcontrib>Zhai, Kun</creatorcontrib><creatorcontrib>Geng, Bingzhi</creatorcontrib><creatorcontrib>Dong, Zhenkun</creatorcontrib><creatorcontrib>Ji, Lei</creatorcontrib><creatorcontrib>Chen, Hui</creatorcontrib><creatorcontrib>Cui, Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiological genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Qiang</au><au>Sun, Yichao</au><au>Zhai, Kun</au><au>Geng, Bingzhi</au><au>Dong, Zhenkun</au><au>Ji, Lei</au><au>Chen, Hui</au><au>Cui, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microbiota-induced inflammatory responses in bladder tumors promote epithelial-mesenchymal transition and enhanced immune infiltration</atitle><jtitle>Physiological genomics</jtitle><addtitle>Physiol Genomics</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>56</volume><issue>8</issue><spage>544</spage><epage>554</epage><pages>544-554</pages><issn>1094-8341</issn><issn>1531-2267</issn><eissn>1531-2267</eissn><abstract>The intratumoral microbiota can modulate the tumor immune microenvironment (TIME); however, the underlying mechanism by which intratumoral microbiota influences the TIME in urothelial carcinoma of the bladder (UCB) remains unclear. To address this, we collected samples from 402 patients with UCB, including paired host transcriptome and tumor microbiome data, from The Cancer Genome Atlas (TCGA). We found that the intratumoral microbiome profiles were significantly correlated with the expression pattern of epithelial-mesenchymal transition (EMT)-related genes. Furthermore, we detected that the genera
and
in tumors could indirectly promote the EMT program by inducing an inflammatory response. Moreover, the inflammatory response induced by these two intratumoral bacteria further enhanced intratumoral immune infiltration, affecting patient survival and response to immunotherapy. In addition, an independent immunotherapy cohort of 348 patients with bladder cancer was used to validate our results. Collectively, our study elucidates the potential mechanism by which the intratumoral microbiota influences the TIME of UCB and provides a new guiding strategy for the targeted therapy of UCB.
The intratumoral microbiota may mediate the bladder tumor inflammatory response, thereby promoting the epithelial-mesenchymal transition program and influencing tumor immune infiltration.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>38808774</pmid><doi>10.1152/physiolgenomics.00032.2024</doi><tpages>11</tpages><orcidid>https://orcid.org/0009-0007-0536-0063</orcidid></addata></record> |
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subjects | Bladder Clostridiales - genetics Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic Humans Immunotherapy Immunotherapy - methods Infiltration Inflammation Inflammation - immunology Inflammation - microbiology Male Metastases Microbiomes Microbiota Microenvironments Middle Aged Transcriptome - genetics Transcriptomes Tumor Microenvironment - immunology Tumors Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - microbiology Urinary Bladder Neoplasms - pathology Urothelial carcinoma |
title | Microbiota-induced inflammatory responses in bladder tumors promote epithelial-mesenchymal transition and enhanced immune infiltration |
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