Controlled cell proliferation and immortalization of human dental pulp stem cells with a doxycycline‐inducible expression system

Human dental pulp stem cells are a potentially useful resource for cell‐based therapies and tissue repair in dental and medical applications. However, the primary culture of isolated dental pulp stem cells has notably been limited. A major requirement of an ideal human dental pulp stem cell culture...

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Veröffentlicht in:	Cell biochemistry and function 2024-06, Vol.42 (4), p.e4064-n/a
Hauptverfasser:	Orimoto, Ai, Addison, William N., Mochizuki, Shinichi, Ariyoshi, Wataru, Ono, Kentaro, Kitamura, Chiaki, Kiyono, Tohru, Fukuda, Tomokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Biomarkers Cell culture Cell differentiation Cell Differentiation - drug effects Cell proliferation Cell Proliferation - drug effects Cells, Cultured Comparative analysis Cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism Cyclin-Dependent Kinase 4 - genetics Cyclin-Dependent Kinase 4 - metabolism Dental materials Dental pulp Dental Pulp - cytology Dental Pulp - metabolism Differentiation (biology) Doxycycline Doxycycline - pharmacology Gene expression Genes Genomics human dental pulp stem cells Humans Immortalization Kinases Life span Mutants R24C mutant cyclin‐dependent kinase 4 RNA-directed DNA polymerase Stem cells Stem Cells - cytology Stem Cells - metabolism Telomerase Telomerase - genetics Telomerase - metabolism Telomerase reverse transcriptase Tissue culture
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