Impaired vestibular function associated with orthostatic hypotension in patients with multiple system atrophy
Background Orthostatic hypotension (OH) is one of the most common symptoms in patients with multiple system atrophy (MSA). Vestibular system plays an important role in blood pressure regulation during orthostatic challenges through vestibular-sympathetic reflex. The current study aimed to investigat...
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| Veröffentlicht in: | Journal of neurology 2024-06, Vol.271 (6), p.3486-3495 |
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| creator | Wang, Xue Mei, Shanshan Lin, Zhongxi Huang, Zhaoyang Mao, Wei Chan, Piu |
| description | Background
Orthostatic hypotension (OH) is one of the most common symptoms in patients with multiple system atrophy (MSA). Vestibular system plays an important role in blood pressure regulation during orthostatic challenges through vestibular-sympathetic reflex. The current study aimed to investigate the relationship between vestibular function and OH in patients with MSA.
Methods
Participants with MSA, including 20 with OH (mean age, 57.55 ± 8.44 years; 7 females) and 15 without OH (mean age, 59.00 ± 8.12 years; 2 females) and 18 healthy controls (mean age, 59.03 ± 6.44 years; 8 females) were enrolled. Cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) tests were conducted to evaluate vestibular function.
Results
Patients with MSA presented with significantly higher rate of absent cVEMPs (57.1% vs 11.1%,
p
= 0.001) and oVEMPs (25.7% vs 0,
p
= 0.021) than controls. MSA patients with OH showed more absent cVEMPs (75.0% vs 11.1%, Bonferroni corrected
p
|
| doi_str_mv | 10.1007/s00415-024-12324-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3061782480</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3061509985</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-209a72b793a25c03667e57de15295f9bb8abf88575902c71ba6dcff98c7bb2093</originalsourceid><addsrcrecordid>eNp9kUFvFSEUhYmxsc_qH3BhJnHjZuwFhgGWpqnapEk3dU2Ax_hoZoaRy2jev5fXqZq4cAMJ5zvnAoeQNxQ-UAB5iQAdFS2wrqWMn9ZnZEc7zlraCf2c7IB30AouunPyEvEBAFQVXpBzrgRTtGc7Mt1Mi4057JsfAUt062hzM6yzLzHNjUVMPtpS5Z-xHJqUyyFhsSX65nBcUgkznrg4N0s9DHPBDZzWscRlDA0esYSpsSWn5XB8Rc4GO2J4_bRfkK-fru-vvrS3d59vrj7etp6zvrQMtJXMSc0tEx5438sg5D5QwbQYtHPKukEpIYUG5iV1tt_7YdDKS-eqmV-Q91vuktP3tT7MTBF9GEc7h7Si4dBTqVinoKLv_kEf0prnertHSoDWSlSKbZTPCTGHwSw5TjYfDQVzKsNsZZhahnksw9BqevsUvbop7P9Yfv9-BfgGYJXmbyH_nf2f2F8AIZa3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3061509985</pqid></control><display><type>article</type><title>Impaired vestibular function associated with orthostatic hypotension in patients with multiple system atrophy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Wang, Xue ; Mei, Shanshan ; Lin, Zhongxi ; Huang, Zhaoyang ; Mao, Wei ; Chan, Piu</creator><creatorcontrib>Wang, Xue ; Mei, Shanshan ; Lin, Zhongxi ; Huang, Zhaoyang ; Mao, Wei ; Chan, Piu</creatorcontrib><description>Background
Orthostatic hypotension (OH) is one of the most common symptoms in patients with multiple system atrophy (MSA). Vestibular system plays an important role in blood pressure regulation during orthostatic challenges through vestibular-sympathetic reflex. The current study aimed to investigate the relationship between vestibular function and OH in patients with MSA.
Methods
Participants with MSA, including 20 with OH (mean age, 57.55 ± 8.44 years; 7 females) and 15 without OH (mean age, 59.00 ± 8.12 years; 2 females) and 18 healthy controls (mean age, 59.03 ± 6.44 years; 8 females) were enrolled. Cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) tests were conducted to evaluate vestibular function.
Results
Patients with MSA presented with significantly higher rate of absent cVEMPs (57.1% vs 11.1%,
p
= 0.001) and oVEMPs (25.7% vs 0,
p
= 0.021) than controls. MSA patients with OH showed more absent cVEMPs (75.0% vs 11.1%, Bonferroni corrected
p
< 0.001) and oVEMPs (40.0% vs 0, Bonferroni corrected
p
= 0.003) than controls. Patients with OH also showed higher rate of absent cVEMPs than those without OH (33.3%, Bonferroni corrected
p
= 0.014).
Conclusions
Our results demonstrated that impairment of vestibular function was associated with MSA, particularly in those with OH. Absent VEMPs may be a potential marker for MSA severity. Our findings suggest that impaired vestibular function is involved in OH development and may serve as an intervention target.</description><identifier>ISSN: 0340-5354</identifier><identifier>ISSN: 1432-1459</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-024-12324-1</identifier><identifier>PMID: 38528162</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Age ; Aged ; Atrophy ; Blood pressure ; Female ; Females ; Humans ; Hypotension ; Hypotension, Orthostatic - etiology ; Hypotension, Orthostatic - physiopathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multiple System Atrophy - complications ; Multiple System Atrophy - physiopathology ; Neurology ; Neuroradiology ; Neurosciences ; Original Communication ; Orthostatic hypotension ; Vestibular Diseases - complications ; Vestibular Diseases - physiopathology ; Vestibular Evoked Myogenic Potentials - physiology ; Vestibular Function Tests ; Vestibular system</subject><ispartof>Journal of neurology, 2024-06, Vol.271 (6), p.3486-3495</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-209a72b793a25c03667e57de15295f9bb8abf88575902c71ba6dcff98c7bb2093</cites><orcidid>0000-0002-7690-9013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-024-12324-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-024-12324-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38528162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xue</creatorcontrib><creatorcontrib>Mei, Shanshan</creatorcontrib><creatorcontrib>Lin, Zhongxi</creatorcontrib><creatorcontrib>Huang, Zhaoyang</creatorcontrib><creatorcontrib>Mao, Wei</creatorcontrib><creatorcontrib>Chan, Piu</creatorcontrib><title>Impaired vestibular function associated with orthostatic hypotension in patients with multiple system atrophy</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>Background
Orthostatic hypotension (OH) is one of the most common symptoms in patients with multiple system atrophy (MSA). Vestibular system plays an important role in blood pressure regulation during orthostatic challenges through vestibular-sympathetic reflex. The current study aimed to investigate the relationship between vestibular function and OH in patients with MSA.
Methods
Participants with MSA, including 20 with OH (mean age, 57.55 ± 8.44 years; 7 females) and 15 without OH (mean age, 59.00 ± 8.12 years; 2 females) and 18 healthy controls (mean age, 59.03 ± 6.44 years; 8 females) were enrolled. Cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) tests were conducted to evaluate vestibular function.
Results
Patients with MSA presented with significantly higher rate of absent cVEMPs (57.1% vs 11.1%,
p
= 0.001) and oVEMPs (25.7% vs 0,
p
= 0.021) than controls. MSA patients with OH showed more absent cVEMPs (75.0% vs 11.1%, Bonferroni corrected
p
< 0.001) and oVEMPs (40.0% vs 0, Bonferroni corrected
p
= 0.003) than controls. Patients with OH also showed higher rate of absent cVEMPs than those without OH (33.3%, Bonferroni corrected
p
= 0.014).
Conclusions
Our results demonstrated that impairment of vestibular function was associated with MSA, particularly in those with OH. Absent VEMPs may be a potential marker for MSA severity. Our findings suggest that impaired vestibular function is involved in OH development and may serve as an intervention target.</description><subject>Age</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Blood pressure</subject><subject>Female</subject><subject>Females</subject><subject>Humans</subject><subject>Hypotension</subject><subject>Hypotension, Orthostatic - etiology</subject><subject>Hypotension, Orthostatic - physiopathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multiple System Atrophy - complications</subject><subject>Multiple System Atrophy - physiopathology</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Orthostatic hypotension</subject><subject>Vestibular Diseases - complications</subject><subject>Vestibular Diseases - physiopathology</subject><subject>Vestibular Evoked Myogenic Potentials - physiology</subject><subject>Vestibular Function Tests</subject><subject>Vestibular system</subject><issn>0340-5354</issn><issn>1432-1459</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFvFSEUhYmxsc_qH3BhJnHjZuwFhgGWpqnapEk3dU2Ax_hoZoaRy2jev5fXqZq4cAMJ5zvnAoeQNxQ-UAB5iQAdFS2wrqWMn9ZnZEc7zlraCf2c7IB30AouunPyEvEBAFQVXpBzrgRTtGc7Mt1Mi4057JsfAUt062hzM6yzLzHNjUVMPtpS5Z-xHJqUyyFhsSX65nBcUgkznrg4N0s9DHPBDZzWscRlDA0esYSpsSWn5XB8Rc4GO2J4_bRfkK-fru-vvrS3d59vrj7etp6zvrQMtJXMSc0tEx5438sg5D5QwbQYtHPKukEpIYUG5iV1tt_7YdDKS-eqmV-Q91vuktP3tT7MTBF9GEc7h7Si4dBTqVinoKLv_kEf0prnertHSoDWSlSKbZTPCTGHwSw5TjYfDQVzKsNsZZhahnksw9BqevsUvbop7P9Yfv9-BfgGYJXmbyH_nf2f2F8AIZa3</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Wang, Xue</creator><creator>Mei, Shanshan</creator><creator>Lin, Zhongxi</creator><creator>Huang, Zhaoyang</creator><creator>Mao, Wei</creator><creator>Chan, Piu</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7690-9013</orcidid></search><sort><creationdate>20240601</creationdate><title>Impaired vestibular function associated with orthostatic hypotension in patients with multiple system atrophy</title><author>Wang, Xue ; Mei, Shanshan ; Lin, Zhongxi ; Huang, Zhaoyang ; Mao, Wei ; Chan, Piu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-209a72b793a25c03667e57de15295f9bb8abf88575902c71ba6dcff98c7bb2093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Blood pressure</topic><topic>Female</topic><topic>Females</topic><topic>Humans</topic><topic>Hypotension</topic><topic>Hypotension, Orthostatic - etiology</topic><topic>Hypotension, Orthostatic - physiopathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multiple System Atrophy - complications</topic><topic>Multiple System Atrophy - physiopathology</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Original Communication</topic><topic>Orthostatic hypotension</topic><topic>Vestibular Diseases - complications</topic><topic>Vestibular Diseases - physiopathology</topic><topic>Vestibular Evoked Myogenic Potentials - physiology</topic><topic>Vestibular Function Tests</topic><topic>Vestibular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xue</creatorcontrib><creatorcontrib>Mei, Shanshan</creatorcontrib><creatorcontrib>Lin, Zhongxi</creatorcontrib><creatorcontrib>Huang, Zhaoyang</creatorcontrib><creatorcontrib>Mao, Wei</creatorcontrib><creatorcontrib>Chan, Piu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xue</au><au>Mei, Shanshan</au><au>Lin, Zhongxi</au><au>Huang, Zhaoyang</au><au>Mao, Wei</au><au>Chan, Piu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired vestibular function associated with orthostatic hypotension in patients with multiple system atrophy</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>271</volume><issue>6</issue><spage>3486</spage><epage>3495</epage><pages>3486-3495</pages><issn>0340-5354</issn><issn>1432-1459</issn><eissn>1432-1459</eissn><abstract>Background
Orthostatic hypotension (OH) is one of the most common symptoms in patients with multiple system atrophy (MSA). Vestibular system plays an important role in blood pressure regulation during orthostatic challenges through vestibular-sympathetic reflex. The current study aimed to investigate the relationship between vestibular function and OH in patients with MSA.
Methods
Participants with MSA, including 20 with OH (mean age, 57.55 ± 8.44 years; 7 females) and 15 without OH (mean age, 59.00 ± 8.12 years; 2 females) and 18 healthy controls (mean age, 59.03 ± 6.44 years; 8 females) were enrolled. Cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs) tests were conducted to evaluate vestibular function.
Results
Patients with MSA presented with significantly higher rate of absent cVEMPs (57.1% vs 11.1%,
p
= 0.001) and oVEMPs (25.7% vs 0,
p
= 0.021) than controls. MSA patients with OH showed more absent cVEMPs (75.0% vs 11.1%, Bonferroni corrected
p
< 0.001) and oVEMPs (40.0% vs 0, Bonferroni corrected
p
= 0.003) than controls. Patients with OH also showed higher rate of absent cVEMPs than those without OH (33.3%, Bonferroni corrected
p
= 0.014).
Conclusions
Our results demonstrated that impairment of vestibular function was associated with MSA, particularly in those with OH. Absent VEMPs may be a potential marker for MSA severity. Our findings suggest that impaired vestibular function is involved in OH development and may serve as an intervention target.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38528162</pmid><doi>10.1007/s00415-024-12324-1</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7690-9013</orcidid></addata></record> |
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| ispartof | Journal of neurology, 2024-06, Vol.271 (6), p.3486-3495 |
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| subjects | Age Aged Atrophy Blood pressure Female Females Humans Hypotension Hypotension, Orthostatic - etiology Hypotension, Orthostatic - physiopathology Male Medicine Medicine & Public Health Middle Aged Multiple System Atrophy - complications Multiple System Atrophy - physiopathology Neurology Neuroradiology Neurosciences Original Communication Orthostatic hypotension Vestibular Diseases - complications Vestibular Diseases - physiopathology Vestibular Evoked Myogenic Potentials - physiology Vestibular Function Tests Vestibular system |
| title | Impaired vestibular function associated with orthostatic hypotension in patients with multiple system atrophy |
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