Effects of housing condition on the development and persistence of addictive-like behavior induced by toluene

Environmental factors can modify addictive responses induced by drugs of abuse; however, little is known about the impact of environmental conditions on behavioral responses induced by inhalants. In this study, we analyzed the effects of housing conditions, considering environmental enrichment (EE; n = 10), social isolation (SI; n = 10), and standard housing (STD; n = 10), as positive, negative, and control environments, respectively, on the development and persistence of behavioral sensitization induced by toluene. Mice exposed to air were used as a comparative control groups for each housing condition (EE: n = 11, SI: n = 10 and STD: n = 11). Results showed that a history of toluene exposure induced the development of locomotor sensitization in mice, independent of their housing conditions. However, SI increased the expression of behavioral sensitization to toluene after a drug-free period. [Display omitted] •All mice exposed to toluene developed locomotor sensitization, despite of the housing condition.•Social isolation enhanced expression of behavioral sensitization induced by toluene.•Stressful conditions play a critical role in addictive-like behavior induced by toluene.