Electrochemical quinuclidine-mediated Minisci-type acylation of N-heterocycles with aldehydes
The electro-generation of acyl radicals from both aromatic and aliphatic aldehydes remains an unmet challenge. We provide a solution to this challenge by merging electro-oxidation and a quinuclidine-mediated hydrogen atom transfer strategy. The generation of acyl radicals at decreased applied potent...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2024-06, Vol.6 (48), p.6174-6177 |
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| container_end_page | 6177 |
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| container_issue | 48 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Li, Yongmei Sun, Liangbo Huang, Shengyang Xu, Kun Zeng, Cheng-Chu |
| description | The electro-generation of acyl radicals from both aromatic and aliphatic aldehydes remains an unmet challenge. We provide a solution to this challenge by merging electro-oxidation and a quinuclidine-mediated hydrogen atom transfer strategy. The generation of acyl radicals at decreased applied potentials compared to that of formyl oxidation exhibits excellent functional group compatibility.
The electro-generation of acyl radicals from both aromatic and aliphatic aldehydes is a synthetic challenge. We addressed this challenge by merging electro-oxidation and a quinuclidine-mediated HAT strategy. |
| doi_str_mv | 10.1039/d4cc00800f |
| format | Article |
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| ispartof | Chemical communications (Cambridge, England), 2024-06, Vol.6 (48), p.6174-6177 |
| issn | 1359-7345 1364-548X |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Acylation Aldehydes Functional groups Hydrogen atoms Oxidation |
| title | Electrochemical quinuclidine-mediated Minisci-type acylation of N-heterocycles with aldehydes |
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