Characterizing the distinct imaging phenotypes, clinical behavior, and genetic vulnerability of brain maturational subtypes in mood disorders

Mood disorders are characterized by great heterogeneity in clinical manifestation. Uncovering such heterogeneity using neuroimaging-based individual biomarkers, clinical behaviors, and genetic risks, might contribute to elucidating the etiology of these diseases and support precision medicine. We re...

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Veröffentlicht in:	Psychological medicine 2024-07, Vol.54 (10), p.2774-2784
Hauptverfasser:	Zheng, Junjie, Zong, Xiaofen, Tang, Lili, Guo, Huiling, Zhao, Pengfei, Womer, Fay Y, Zhang, Xizhe, Tang, Yanqing, Wang, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer's disease Behavior Biological markers Biomarkers Bipolar disorder Bipolar Disorder - diagnostic imaging Bipolar Disorder - genetics Bipolar Disorder - physiopathology Brain Brain - diagnostic imaging Brain - pathology Case-Control Studies Clustering Cognition Cognitive impairment Cortex Cortex (frontal) Depressive Disorder, Major - diagnostic imaging Depressive Disorder, Major - genetics Depressive personality disorders Emotional disorders Endothelial cells Etiology Female Genetic Predisposition to Disease Genetic susceptibility Gray Matter - diagnostic imaging Gray Matter - pathology Heterogeneity Hospitals Humans Magnetic Resonance Imaging Male Maturation Medical imaging Mental depression Mental disorders Microglia Middle Aged Mood Mood disorders Mood Disorders - genetics Neurodegenerative diseases Neuroimaging Neurons Oligodendrocytes Phenotype Phenotypes Polygenic inheritance Precision medicine Psychiatry Psychopathology Substantia grisea Subtypes Symptoms Transcriptomes Transcriptomics Vulnerability
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