A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection

Antibody-mediated rejection is a leading cause of kidney-transplant failure. The targeting of CD38 to inhibit graft injury caused by alloantibodies and natural killer (NK) cells may be a therapeutic option. In this phase 2, double-blind, randomized, placebo-controlled trial, we assigned patients wit...

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Veröffentlicht in:	The New England journal of medicine 2024-07, Vol.391 (2), p.122-132
Hauptverfasser:	Mayer, Katharina A., Schrezenmeier, Eva, Diebold, Matthias, Halloran, Philip F., Schatzl, Martina, Schranz, Sabine, Haindl, Susanne, Kasbohm, Silke, Kainz, Alexander, Eskandary, Farsad, Doberer, Konstantin, Patel, Uptal D., Dudani, Jaideep S., Regele, Heinz, Kozakowski, Nicolas, Kläger, Johannes, Boxhammer, Rainer, Amann, Kerstin, Puchhammer-Stöckl, Elisabeth, Vietzen, Hannes, Beck, Julia, Schütz, Ekkehard, Akifova, Aylin, Firbas, Christa, Gilbert, Houston N., Osmanodja, Bilgin, Halleck, Fabian, Jilma, Bernd, Budde, Klemens, Böhmig, Georg A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy Alloantibodies Allografts Antibodies Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - immunology Antibodies, Monoclonal, Humanized - therapeutic use Biopsy Body weight CD38 antigen Clinical Medicine Clinical Medicine General Confidence intervals Creatinine Double-Blind Method Female Graft rejection Graft Rejection - drug therapy Graft Rejection - etiology Graft Rejection - immunology Hospital-Based Clinical Medicine Humans Hypothesis testing Immunology Immunology General Inflammation Isoantibodies - blood Isoantibodies - immunology Kidney - drug effects Kidney - immunology Kidney - pathology Kidney Transplantation Kidney Transplantation - adverse effects Killer Cells, Natural - immunology Male Microvasculature Middle Aged Monoclonal antibodies Natural killer cells Nephrology Patients Placebos Plasma Renal failure Side effects Surgery T-Cells Transplantation Transplants & implants
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