Loss of RBM45 inhibits breast cancer progression by reducing the SUMOylation of IRF7 to promote IFNB1 transcription

Type I interferons exhibit anti-proliferative and anti-cancer activities, but their detailed regulatory mechanisms in cancer have not been fully elucidated yet. RNA binding proteins are master orchestrators of gene regulation, which are closely related to tumor progression. Here we show that the upr...

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Veröffentlicht in:	Cancer letters 2024-08, Vol.596, p.216988, Article 216988
Hauptverfasser:	Lv, Yuesheng, Sun, Siwen, Zhang, Jinrui, Wang, Chong, Chen, Chaoqun, Zhang, Qianyi, Zhao, Jinyao, Qi, Yangfan, Zhang, Wenjing, Wang, Yang, Li, Man
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation Disease Progression Female Gene Expression Regulation, Neoplastic Humans IFNB1 Interferon Regulatory Factor-7 - genetics Interferon Regulatory Factor-7 - metabolism Interferon-beta - genetics Interferon-beta - metabolism IRF7 Mice Mice, Inbred BALB C Mice, Nude RBM45 RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Signal Transduction SUMOylation Transcription, Genetic Tripartite Motif-Containing Protein 28 - genetics Tripartite Motif-Containing Protein 28 - metabolism Xenograft Model Antitumor Assays
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