Population pharmacokinetics and dosage optimization of linezolid in Chinese older patients

Purpose To assess the pharmacokinetics and pharmacodynamics of linezolid in a retrospective cohort of hospitalized Chinese older patients. Methods Patients > 60 years of age, who received intravenous linezolid (600 mg), were included. A population pharmacokinetics (PPK) model was established usin...

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Veröffentlicht in:	European journal of clinical pharmacology 2024-09, Vol.80 (9), p.1295-1304
Hauptverfasser:	Li, Yuanchen, Fang, Qiu, Wu, Zejun, Huang, Siqi, Ge, Weihong, Shen, Jizhong, Zhu, Huaijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Linezolid Minimum inhibitory concentration Monte Carlo simulation Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Uric acid
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