Curcuminoid PBPD induces cuproptosis and endoplasmic reticulum stress in cervical cancer via the Notch1/RBP‐J/NRF2/FDX1 pathway

Curcumin has been shown to have antitumor properties, but its low potency and bioavailability has limited its clinical application. We designed a novel curcuminoid, [1‐propyl‐3,5‐bis(2‐bromobenzylidene)‐4‐piperidinone] (PBPD), which has higher antitumor strength and improves bioavailability. Cell co...

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Veröffentlicht in:	Molecular carcinogenesis 2024-08, Vol.63 (8), p.1449-1466
Hauptverfasser:	Zhang, Min‐Jie, Shi, Mengna, Yu, Yang, Ou, Rongying, Ge, Ren‐shan, Duan, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Animals Bioavailability Cell death Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Cervical cancer Curcumin Curcumin - analogs & derivatives Curcumin - pharmacology curcuminoid DNA-directed RNA polymerase Drug development Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Female Ferredoxin ferredoxin 1 Gene expression Gene Expression Regulation, Neoplastic - drug effects HeLa Cells Humans Immunofluorescence Mice NADPH-diaphorase NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Notch1 protein NRF2 protein Oxidative stress Proteins reactive oxidative species Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Ribonucleic acid RNA Sequence analysis Signal Transduction - drug effects Stress thioredoxin 1 Transcriptomes Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology
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