Exploiting Hydrophobic Amino Acid Scanning to Develop Cyclic Peptide Inhibitors of the SARS‐CoV‐2 Main Protease with Antiviral Activity

The development of novel antivirals is crucial not only for managing current COVID‐19 infections but for addressing potential future zoonotic outbreaks. SARS‐CoV‐2 main protease (Mpro) is vital for viral replication and viability and therefore serves as an attractive target for antiviral interventio...

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Veröffentlicht in:	Chemistry : a European journal 2024-08, Vol.30 (44), p.e202401606-n/a
Hauptverfasser:	Harrison, Katriona, Carlos, Patrick W., Ullrich, Sven, Aggarwal, Anupriya, Johansen‐Leete, Jason, Sasi, Vishnu Mini, Barter, Isabel, Maxwell, Joshua W. C., Bedding, Max J., Larance, Mark, Turville, Stuart, Norman, Alexander, Jackson, Colin J., Nitsche, Christoph, Payne, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Antiviral activity Antiviral agents Cell permeability COVID-19 Cyclic peptides Hydrophobicity Main protease mRNA Peptide inhibitors Peptides Permeability Protease Protease inhibitors Proteinase inhibitors Residues SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Viral diseases
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