Neuroprotective effect of emodin on Aβ25-35-induced cytotoxicity in PC12 cells involves Nrf2/GPX4 and TLR4/p-NF-κB/NLRP3 pathways

[Display omitted] •Emodin ameliorated the cell viability harmed by Aβ25-35.•Emodin relieved the MMP decline, reduced ROS release, and decreased MDA but improved CAT and GSH-Px activity.•Emodin bound to Fe2+ via phenolic hydroxyl groups to decrease free Fe2+.•Emodin upregulated Nrf2/GPX4 pathway to e...

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Veröffentlicht in:	Brain research 2024-10, Vol.1841, p.149019, Article 149019
Hauptverfasser:	Xia, Nengyin, Xu, Lingyun, Xu, Dengrui, Huang, Mengyuan, Li, Yang, Mei, Zhinan, Yu, Zejun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Anti-inflammatory Antioxidant Emodin Ferroptosis Nrf2/GPX4 pathway TLR4/p-NF-κB/NLRP3 pathway
Online-Zugang:	Volltext
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