Evaluating the impact of anatomical and physiological variability on human equivalent doses using PBPK models

Addressing human anatomical and physiological variability is a crucial component of human health risk assessment of chemicals. Experts have recommended probabilistic chemical risk assessment paradigms in which distributional adjustment factors are used to account for various sources of uncertainty a...

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Veröffentlicht in:	Toxicological sciences 2024-08, Vol.200 (2), p.241-264
Hauptverfasser:	Schacht, Celia M, Meade, Annabel E, Bernstein, Amanda S, Prasad, Bidya, Schlosser, Paul M, Tran, Hien T, Kapraun, Dustin F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chloroform - pharmacokinetics Dose-Response Relationship, Drug Humans Models, Biological Risk Assessment Tissue Distribution Uncertainty
Online-Zugang:	Volltext
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