Signal peptide replacement of Ag43 enables an efficient bacterial cell surface display of receptor-binding domain of coronavirus

To enable an efficient bacterial cell surface display with effective protein expression and cell surface loading ability via autotransporter for potential vaccine development applications, the inner membrane protein translocation efficiency was investigated via a trial-and-error strategy by replacin...

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Veröffentlicht in:	Biochemical and biophysical research communications 2024-08, Vol.721, p.150146, Article 150146
Hauptverfasser:	Zhang, Xuyan, Qin, Youcai, Han, Xiaochen, Li, Qingrong, Wang, Zhe, Wang, Xingyuan, Zhao, Leyi, Zhang, Hanqing, Cai, Kun, Chu, Yindi, Gao, Cuijuan, Fan, Enguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Ag43 Bacterial surface display Cell Membrane - metabolism Cell Surface Display Techniques Display efficiency Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Protein Binding Protein Domains Protein Sorting Signals RBD Signal peptide
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