An Anti-VEGF-B Antibody Reduces Abnormal Tumor Vasculature and Enhances the Effects of Chemotherapy

The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key regulators of blood vessel formation, including in tumors, where their deregulated function can promote the production of aberrant, leaky blood vessels, supporting tumor development. Here we investigated the VEGFR1...

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Veröffentlicht in:	Cancers 2024-05, Vol.16 (10), p.1902
Hauptverfasser:	Janes, Peter W, Parslow, Adam C, Cao, Diana, Rigopoulos, Angela, Lee, Fook-Thean, Gong, Sylvia J, Cartwright, Glenn A, Burvenich, Ingrid J G, Eriksson, Ulf, Johns, Terrance G, Scott, Fiona E, Scott, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antigens Bevacizumab Biodistribution Blood vessels Breast cancer Cable television broadcasting industry Cancer Cancer therapies Chemotherapy Colorectal cancer Colorectal carcinoma Disease Fatty acids Glioma Growth factors Kidney cancer Kinases Liver cancer Medical prognosis Melanoma Metastasis Monoclonal antibodies Neovascularization Ovaries Prostate Protein binding Proteins Spleen Squamous cell carcinoma Stroma Tumor cells Tumors Type 2 diabetes Vascular endothelial growth factor
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