Epigenetic Modulation of GPER Expression in Gastric and Colonic Smooth Muscle of Male and Female Non-Obese Diabetic (NOD) Mice: Insights into H3K4me3 and H3K27ac Modifications

Type 1 diabetes (T1D) affects gastrointestinal (GI) motility, favoring gastroparesis, constipation, and fecal incontinence, which are more prevalent in women. The mechanisms are unknown. Given the G-protein-coupled estrogen receptor's (GPER) role in GI motility, we investigated sex-related diab...

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Veröffentlicht in:	International journal of molecular sciences 2024-05, Vol.25 (10), p.5260
Hauptverfasser:	Hixon, Juanita C, Rivas Zarete, Jatna I, White, Jason, Hilaire, Mariline, Muhammad, Aliyu, Yusuf, Abdurrahman Pharmacy, Adu-Addai, Benjamin, Yates, Clayton C, Mahavadi, Sunila
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Chromatin Colon - metabolism Colon - pathology Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism DNA Methylation Enzyme-linked immunosorbent assay Epigenesis, Genetic Epigenetic inheritance Epigenetics Estrogen Estrogens Fecal incontinence Female Females Gastroesophageal reflux Gastrointestinal system Genes Health aspects Histones - metabolism Male Males Methylation Methyltransferases Mice Mice, Inbred NOD Muscle, Smooth - metabolism Promoter Regions, Genetic Proteins Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA Sexes Smooth muscle Stomach - pathology Type 1 diabetes Type 2 diabetes
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