AdeIJK Pump-Specific Inhibitors Effective against Multidrug Resistant Acinetobacter baumannii

Multidrug-resistant Acinetobacter baumannii is a serious threat pathogen rapidly spreading in clinics and causing a range of complicated human infections. The major contributor to A. baumannii antibiotic resistance is the overproduction of AdeIJK and AdeABC multidrug efflux pumps of the resistance-n...

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Veröffentlicht in:	ACS infectious diseases 2024-06, Vol.10 (6), p.2239-2249
Hauptverfasser:	Tambat, Rushikesh, Kinthada, Rama Kumar, Saral Sariyer, Aysegul, Leus, Inga V., Sariyer, Emrah, D’Cunha, Napoleon, Zhou, Hinman, Leask, Makaila, Walker, John K., Zgurskaya, Helen I.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Acinetobacter baumannii - drug effects Acinetobacter Infections - drug therapy Acinetobacter Infections - microbiology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Drug Resistance, Multiple, Bacterial - drug effects Drug Synergism Humans Membrane Transport Proteins - metabolism Microbial Sensitivity Tests
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