Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis
Background: Transnasal endoscopy (TNE) does not require general anesthesia, an attractive characteristic for monitoring eosinophilic esophagitis (EoE). We evaluated the adequacy of TNE-obtained esophageal biopsies using the EoE Histology Scoring System (EoEHSS). Methods: The Cincinnati Center for Eo...
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| Veröffentlicht in: | Pediatric and developmental pathology 2024-07, Vol.27 (4), p.327-334 |
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| creator | Lopez-Nunez, Oscar Bernieh, Anas Kliewer, Kara L. Kemtur, Pratibha Bolton, Scott M. Mukkada, Vincent A. Schablein, Ryan Woods, Christopher Rothenberg, Marc E. Collins, Margaret H. |
| description | Background:
Transnasal endoscopy (TNE) does not require general anesthesia, an attractive characteristic for monitoring eosinophilic esophagitis (EoE). We evaluated the adequacy of TNE-obtained esophageal biopsies using the EoE Histology Scoring System (EoEHSS).
Methods:
The Cincinnati Center for Eosinophilic Disorders database was searched for esophageal biopsies obtained by the same endoscopist, using either TNE or conventional endoscopy (CE). Whole-slide biopsy images were evaluated. The Mann-Whitney test was used for median (interquartile range) values and Fisher exact test for categorical variables. P ≤ .05 was considered significant.
Results:
Median age (P = .82) or height (P = .83) did not differ between TNE (n = 17) and CE (n = 17) groups. Although median largest piece size (mm2) differed between the groups (TNE: 0.59 (0.45, 0.86), CE: 2.24 (1.09, 2.82), P |
| doi_str_mv | 10.1177/10935266241255723 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3060377377</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_10935266241255723</sage_id><sourcerecordid>3060377377</sourcerecordid><originalsourceid>FETCH-LOGICAL-c222t-28aea29b4bc74e9f09152b93eddd088d759764461134f870a5089a5eea9138663</originalsourceid><addsrcrecordid>eNp9kc9q3DAQxkVpadJtH6CXomMvTvVf1nG7uG0g0B5SejRae5xV8EpejR3YZ8hLR8smvRQKAxpmft83aIaQj5xdcW7tF86c1MIYobjQ2gr5ilxyw3WlrRKvS1761Qm4IO8Q7xkrIsPekgtZW6ecUpfk8Tb7iNGjH2kT-4Rdmo503R2WkAFpg2na-Tso3a8hTRhKbd3DYfEz0CFlukn7KcMOIoYHoL_8vEtjujvS5sGPBQop0hBP9QBxRvonzDvaJAyx-IYxdC8TwhzwPXkz-BHhw_O7Ir-_NbebH9XNz-_Xm_VN1Qkh5krUHrxwW7XtrAI3MMe12DoJfd-zuu6tdtYoZTiXaqgt85rVzmsA77isjZEr8vnsO-V0WADndh-wg3H0EdKCrWSGSWtPsSL8jHY5IWYY2imHvc_HlrP2dIP2nxsUzadn-2W7h_6v4mXpBbg6A1g2296nJcfy3f84PgH2sJD5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3060377377</pqid></control><display><type>article</type><title>Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Lopez-Nunez, Oscar ; Bernieh, Anas ; Kliewer, Kara L. ; Kemtur, Pratibha ; Bolton, Scott M. ; Mukkada, Vincent A. ; Schablein, Ryan ; Woods, Christopher ; Rothenberg, Marc E. ; Collins, Margaret H.</creator><creatorcontrib>Lopez-Nunez, Oscar ; Bernieh, Anas ; Kliewer, Kara L. ; Kemtur, Pratibha ; Bolton, Scott M. ; Mukkada, Vincent A. ; Schablein, Ryan ; Woods, Christopher ; Rothenberg, Marc E. ; Collins, Margaret H.</creatorcontrib><description>Background:
Transnasal endoscopy (TNE) does not require general anesthesia, an attractive characteristic for monitoring eosinophilic esophagitis (EoE). We evaluated the adequacy of TNE-obtained esophageal biopsies using the EoE Histology Scoring System (EoEHSS).
Methods:
The Cincinnati Center for Eosinophilic Disorders database was searched for esophageal biopsies obtained by the same endoscopist, using either TNE or conventional endoscopy (CE). Whole-slide biopsy images were evaluated. The Mann-Whitney test was used for median (interquartile range) values and Fisher exact test for categorical variables. P ≤ .05 was considered significant.
Results:
Median age (P = .82) or height (P = .83) did not differ between TNE (n = 17) and CE (n = 17) groups. Although median largest piece size (mm2) differed between the groups (TNE: 0.59 (0.45, 0.86), CE: 2.24 (1.09, 2.82), P < .001), all 8 EoEHSS features were evaluated in each group; only 1 feature (lamina propria fibrosis) was missing in both groups (TNE: 19/34, CE: 11/34, P = .09). The median peak eosinophil count/high-power field differed (TNE: 3 (0, 29), CE: 16 (1, 66), P = .03), but overall grade (TNE: 0.17 (0.10, 0.29), CE: 0.22 (0.14, 0.46), P = .12), stage (TNE: 0.14 (0.10, 0.24), CE: 0.20 (0.10, 0.43), P = .15), and non-eosinophil-related individual EoEHSS scores did not differ.
Conclusions:
TNE- and CE-obtained esophageal biopsies are similarly sufficient for evaluation of key pathological features in EoE.</description><identifier>ISSN: 1093-5266</identifier><identifier>ISSN: 1615-5742</identifier><identifier>EISSN: 1615-5742</identifier><identifier>DOI: 10.1177/10935266241255723</identifier><identifier>PMID: 38794944</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Adult ; Biopsy ; Child ; Child, Preschool ; Eosinophilic Esophagitis - diagnosis ; Eosinophilic Esophagitis - pathology ; Esophagoscopy ; Esophagus - pathology ; Female ; Humans ; Male ; Retrospective Studies</subject><ispartof>Pediatric and developmental pathology, 2024-07, Vol.27 (4), p.327-334</ispartof><rights>2024, Society for Pediatric Pathology All rights reserved</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c222t-28aea29b4bc74e9f09152b93eddd088d759764461134f870a5089a5eea9138663</cites><orcidid>0000-0002-0756-5974 ; 0000-0002-3649-3885 ; 0000-0002-9776-4474</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/10935266241255723$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/10935266241255723$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38794944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopez-Nunez, Oscar</creatorcontrib><creatorcontrib>Bernieh, Anas</creatorcontrib><creatorcontrib>Kliewer, Kara L.</creatorcontrib><creatorcontrib>Kemtur, Pratibha</creatorcontrib><creatorcontrib>Bolton, Scott M.</creatorcontrib><creatorcontrib>Mukkada, Vincent A.</creatorcontrib><creatorcontrib>Schablein, Ryan</creatorcontrib><creatorcontrib>Woods, Christopher</creatorcontrib><creatorcontrib>Rothenberg, Marc E.</creatorcontrib><creatorcontrib>Collins, Margaret H.</creatorcontrib><title>Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis</title><title>Pediatric and developmental pathology</title><addtitle>Pediatr Dev Pathol</addtitle><description>Background:
Transnasal endoscopy (TNE) does not require general anesthesia, an attractive characteristic for monitoring eosinophilic esophagitis (EoE). We evaluated the adequacy of TNE-obtained esophageal biopsies using the EoE Histology Scoring System (EoEHSS).
Methods:
The Cincinnati Center for Eosinophilic Disorders database was searched for esophageal biopsies obtained by the same endoscopist, using either TNE or conventional endoscopy (CE). Whole-slide biopsy images were evaluated. The Mann-Whitney test was used for median (interquartile range) values and Fisher exact test for categorical variables. P ≤ .05 was considered significant.
Results:
Median age (P = .82) or height (P = .83) did not differ between TNE (n = 17) and CE (n = 17) groups. Although median largest piece size (mm2) differed between the groups (TNE: 0.59 (0.45, 0.86), CE: 2.24 (1.09, 2.82), P < .001), all 8 EoEHSS features were evaluated in each group; only 1 feature (lamina propria fibrosis) was missing in both groups (TNE: 19/34, CE: 11/34, P = .09). The median peak eosinophil count/high-power field differed (TNE: 3 (0, 29), CE: 16 (1, 66), P = .03), but overall grade (TNE: 0.17 (0.10, 0.29), CE: 0.22 (0.14, 0.46), P = .12), stage (TNE: 0.14 (0.10, 0.24), CE: 0.20 (0.10, 0.43), P = .15), and non-eosinophil-related individual EoEHSS scores did not differ.
Conclusions:
TNE- and CE-obtained esophageal biopsies are similarly sufficient for evaluation of key pathological features in EoE.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biopsy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Eosinophilic Esophagitis - diagnosis</subject><subject>Eosinophilic Esophagitis - pathology</subject><subject>Esophagoscopy</subject><subject>Esophagus - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Retrospective Studies</subject><issn>1093-5266</issn><issn>1615-5742</issn><issn>1615-5742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9q3DAQxkVpadJtH6CXomMvTvVf1nG7uG0g0B5SejRae5xV8EpejR3YZ8hLR8smvRQKAxpmft83aIaQj5xdcW7tF86c1MIYobjQ2gr5ilxyw3WlrRKvS1761Qm4IO8Q7xkrIsPekgtZW6ecUpfk8Tb7iNGjH2kT-4Rdmo503R2WkAFpg2na-Tso3a8hTRhKbd3DYfEz0CFlukn7KcMOIoYHoL_8vEtjujvS5sGPBQop0hBP9QBxRvonzDvaJAyx-IYxdC8TwhzwPXkz-BHhw_O7Ir-_NbebH9XNz-_Xm_VN1Qkh5krUHrxwW7XtrAI3MMe12DoJfd-zuu6tdtYoZTiXaqgt85rVzmsA77isjZEr8vnsO-V0WADndh-wg3H0EdKCrWSGSWtPsSL8jHY5IWYY2imHvc_HlrP2dIP2nxsUzadn-2W7h_6v4mXpBbg6A1g2296nJcfy3f84PgH2sJD5</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Lopez-Nunez, Oscar</creator><creator>Bernieh, Anas</creator><creator>Kliewer, Kara L.</creator><creator>Kemtur, Pratibha</creator><creator>Bolton, Scott M.</creator><creator>Mukkada, Vincent A.</creator><creator>Schablein, Ryan</creator><creator>Woods, Christopher</creator><creator>Rothenberg, Marc E.</creator><creator>Collins, Margaret H.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0756-5974</orcidid><orcidid>https://orcid.org/0000-0002-3649-3885</orcidid><orcidid>https://orcid.org/0000-0002-9776-4474</orcidid></search><sort><creationdate>202407</creationdate><title>Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis</title><author>Lopez-Nunez, Oscar ; Bernieh, Anas ; Kliewer, Kara L. ; Kemtur, Pratibha ; Bolton, Scott M. ; Mukkada, Vincent A. ; Schablein, Ryan ; Woods, Christopher ; Rothenberg, Marc E. ; Collins, Margaret H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c222t-28aea29b4bc74e9f09152b93eddd088d759764461134f870a5089a5eea9138663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biopsy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Eosinophilic Esophagitis - diagnosis</topic><topic>Eosinophilic Esophagitis - pathology</topic><topic>Esophagoscopy</topic><topic>Esophagus - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopez-Nunez, Oscar</creatorcontrib><creatorcontrib>Bernieh, Anas</creatorcontrib><creatorcontrib>Kliewer, Kara L.</creatorcontrib><creatorcontrib>Kemtur, Pratibha</creatorcontrib><creatorcontrib>Bolton, Scott M.</creatorcontrib><creatorcontrib>Mukkada, Vincent A.</creatorcontrib><creatorcontrib>Schablein, Ryan</creatorcontrib><creatorcontrib>Woods, Christopher</creatorcontrib><creatorcontrib>Rothenberg, Marc E.</creatorcontrib><creatorcontrib>Collins, Margaret H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric and developmental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopez-Nunez, Oscar</au><au>Bernieh, Anas</au><au>Kliewer, Kara L.</au><au>Kemtur, Pratibha</au><au>Bolton, Scott M.</au><au>Mukkada, Vincent A.</au><au>Schablein, Ryan</au><au>Woods, Christopher</au><au>Rothenberg, Marc E.</au><au>Collins, Margaret H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis</atitle><jtitle>Pediatric and developmental pathology</jtitle><addtitle>Pediatr Dev Pathol</addtitle><date>2024-07</date><risdate>2024</risdate><volume>27</volume><issue>4</issue><spage>327</spage><epage>334</epage><pages>327-334</pages><issn>1093-5266</issn><issn>1615-5742</issn><eissn>1615-5742</eissn><abstract>Background:
Transnasal endoscopy (TNE) does not require general anesthesia, an attractive characteristic for monitoring eosinophilic esophagitis (EoE). We evaluated the adequacy of TNE-obtained esophageal biopsies using the EoE Histology Scoring System (EoEHSS).
Methods:
The Cincinnati Center for Eosinophilic Disorders database was searched for esophageal biopsies obtained by the same endoscopist, using either TNE or conventional endoscopy (CE). Whole-slide biopsy images were evaluated. The Mann-Whitney test was used for median (interquartile range) values and Fisher exact test for categorical variables. P ≤ .05 was considered significant.
Results:
Median age (P = .82) or height (P = .83) did not differ between TNE (n = 17) and CE (n = 17) groups. Although median largest piece size (mm2) differed between the groups (TNE: 0.59 (0.45, 0.86), CE: 2.24 (1.09, 2.82), P < .001), all 8 EoEHSS features were evaluated in each group; only 1 feature (lamina propria fibrosis) was missing in both groups (TNE: 19/34, CE: 11/34, P = .09). The median peak eosinophil count/high-power field differed (TNE: 3 (0, 29), CE: 16 (1, 66), P = .03), but overall grade (TNE: 0.17 (0.10, 0.29), CE: 0.22 (0.14, 0.46), P = .12), stage (TNE: 0.14 (0.10, 0.24), CE: 0.20 (0.10, 0.43), P = .15), and non-eosinophil-related individual EoEHSS scores did not differ.
Conclusions:
TNE- and CE-obtained esophageal biopsies are similarly sufficient for evaluation of key pathological features in EoE.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>38794944</pmid><doi>10.1177/10935266241255723</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0756-5974</orcidid><orcidid>https://orcid.org/0000-0002-3649-3885</orcidid><orcidid>https://orcid.org/0000-0002-9776-4474</orcidid></addata></record> |
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| ispartof | Pediatric and developmental pathology, 2024-07, Vol.27 (4), p.327-334 |
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| subjects | Adolescent Adult Biopsy Child Child, Preschool Eosinophilic Esophagitis - diagnosis Eosinophilic Esophagitis - pathology Esophagoscopy Esophagus - pathology Female Humans Male Retrospective Studies |
| title | Transnasal Endoscopy Acquires Esophageal Biopsies Adequate for Comprehensive Pathology Evaluation in Patients With Eosinophilic Esophagitis |
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