Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study
The widespread deposition of amyloid-β (Aβ) plaques in late-stage Alzheimer disease is well defined and confirmed by in vivo PET. However, there are discrepancies between which regions contribute to the earliest topographic Aβ deposition within the neocortex. This study investigated Aβ signals in th...
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| Veröffentlicht in: | Journal of Nuclear Medicine 2024-07, Vol.65 (7), p.1122-1128 |
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| creator | Lecy, Emily E Min, Hoon-Ki Apgar, Christopher J Maltais, Daniela D Lundt, Emily S Albertson, Sabrina M Senjem, Matthew L Schwarz, Christopher G Botha, Hugo Graff-Radford, Jonathan Jones, David T Vemuri, Prashanthi Kantarci, Kejal Knopman, David S Petersen, Ronald C Jack, Jr, Clifford R Lee, Jeyeon Lowe, Val J |
| description | The widespread deposition of amyloid-β (Aβ) plaques in late-stage Alzheimer disease is well defined and confirmed by in vivo PET. However, there are discrepancies between which regions contribute to the earliest topographic Aβ deposition within the neocortex.
This study investigated Aβ signals in the perithreshold SUV ratio range using Pittsburgh compound B (PiB) PET in a population-based study cross-sectionally and longitudinally. PiB PET scans from 1,088 participants determined the early patterns of PiB loading in the neocortex.
Early-stage Aβ loading is seen first in the temporal, cingulate, and occipital regions. Regional early deposition patterns are similar in both apolipoprotein ε4 carriers and noncarriers. Clustering analysis shows groups with different patterns of early amyloid deposition.
These findings of initial Aβ deposition patterns may be of significance for diagnostics and understanding the development of Alzheimer disease phenotypes. |
| doi_str_mv | 10.2967/jnumed.123.267150 |
| format | Article |
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This study investigated Aβ signals in the perithreshold SUV ratio range using Pittsburgh compound B (PiB) PET in a population-based study cross-sectionally and longitudinally. PiB PET scans from 1,088 participants determined the early patterns of PiB loading in the neocortex.
Early-stage Aβ loading is seen first in the temporal, cingulate, and occipital regions. Regional early deposition patterns are similar in both apolipoprotein ε4 carriers and noncarriers. Clustering analysis shows groups with different patterns of early amyloid deposition.
These findings of initial Aβ deposition patterns may be of significance for diagnostics and understanding the development of Alzheimer disease phenotypes.</description><identifier>ISSN: 0161-5505</identifier><identifier>ISSN: 1535-5667</identifier><identifier>EISSN: 1535-5667</identifier><identifier>EISSN: 2159-662X</identifier><identifier>DOI: 10.2967/jnumed.123.267150</identifier><identifier>PMID: 38782458</identifier><language>eng</language><publisher>United States: Society of Nuclear Medicine</publisher><subject>Alzheimer's disease ; Apolipoproteins ; Cerebral cortex ; Cluster analysis ; Clustering ; Deposition ; In vivo methods and tests ; Neocortex ; Neurodegenerative diseases ; Phenotypes ; Population studies ; Positron emission ; Regional development ; β-Amyloid</subject><ispartof>Journal of Nuclear Medicine, 2024-07, Vol.65 (7), p.1122-1128</ispartof><rights>2024 by the Society of Nuclear Medicine and Molecular Imaging.</rights><rights>Copyright Society of Nuclear Medicine Jul 1, 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1268-178e8f1b11ed19c87fd4c833cabe738475d3b18fc163bf8e579e1c9b1ba80a9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38782458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lecy, Emily E</creatorcontrib><creatorcontrib>Min, Hoon-Ki</creatorcontrib><creatorcontrib>Apgar, Christopher J</creatorcontrib><creatorcontrib>Maltais, Daniela D</creatorcontrib><creatorcontrib>Lundt, Emily S</creatorcontrib><creatorcontrib>Albertson, Sabrina M</creatorcontrib><creatorcontrib>Senjem, Matthew L</creatorcontrib><creatorcontrib>Schwarz, Christopher G</creatorcontrib><creatorcontrib>Botha, Hugo</creatorcontrib><creatorcontrib>Graff-Radford, Jonathan</creatorcontrib><creatorcontrib>Jones, David T</creatorcontrib><creatorcontrib>Vemuri, Prashanthi</creatorcontrib><creatorcontrib>Kantarci, Kejal</creatorcontrib><creatorcontrib>Knopman, David S</creatorcontrib><creatorcontrib>Petersen, Ronald C</creatorcontrib><creatorcontrib>Jack, Jr, Clifford R</creatorcontrib><creatorcontrib>Lee, Jeyeon</creatorcontrib><creatorcontrib>Lowe, Val J</creatorcontrib><title>Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study</title><title>Journal of Nuclear Medicine</title><addtitle>J Nucl Med</addtitle><description>The widespread deposition of amyloid-β (Aβ) plaques in late-stage Alzheimer disease is well defined and confirmed by in vivo PET. However, there are discrepancies between which regions contribute to the earliest topographic Aβ deposition within the neocortex.
This study investigated Aβ signals in the perithreshold SUV ratio range using Pittsburgh compound B (PiB) PET in a population-based study cross-sectionally and longitudinally. PiB PET scans from 1,088 participants determined the early patterns of PiB loading in the neocortex.
Early-stage Aβ loading is seen first in the temporal, cingulate, and occipital regions. Regional early deposition patterns are similar in both apolipoprotein ε4 carriers and noncarriers. Clustering analysis shows groups with different patterns of early amyloid deposition.
These findings of initial Aβ deposition patterns may be of significance for diagnostics and understanding the development of Alzheimer disease phenotypes.</description><subject>Alzheimer's disease</subject><subject>Apolipoproteins</subject><subject>Cerebral cortex</subject><subject>Cluster analysis</subject><subject>Clustering</subject><subject>Deposition</subject><subject>In vivo methods and tests</subject><subject>Neocortex</subject><subject>Neurodegenerative diseases</subject><subject>Phenotypes</subject><subject>Population studies</subject><subject>Positron emission</subject><subject>Regional development</subject><subject>β-Amyloid</subject><issn>0161-5505</issn><issn>1535-5667</issn><issn>1535-5667</issn><issn>2159-662X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkE1OwzAQRi0EglI4ABtkiQ2bFE8c2xN2pSo_UgWVgHXkOI6UKomLnSxyLQ7CmUjVsmE10sz7Po0eIVfAZnEq1d2m7RtbzCDms1gqEOyITEBwEQkp1TGZMJAQCcHEGTkPYcMYk4h4Ss44KowTgRPyvtZdZ30bqCvpUvt6oK_WGee7yuiazpuhdlUR_XzTuTF909e6q1x7T-d0vfyga7c9bKIHHWxB37u-GC7ISanrYC8Pc0o-H5cfi-do9fb0spivIgOxxAgUWiwhB7AFpAZVWSQGOTc6t4pjokTBc8DSgOR5iVao1IJJc8g1Mp2WfEpu971b7756G7qsqYKxda1b6_qQcSYZVyJJ1Ije_EM3rvft-N1I4ShPYCxGCvaU8S4Eb8ts66tG-yEDlu2MZ3vj2Wg82xsfM9eH5j7fnf4Sf4r5L2offU8</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Lecy, Emily E</creator><creator>Min, Hoon-Ki</creator><creator>Apgar, Christopher J</creator><creator>Maltais, Daniela D</creator><creator>Lundt, Emily S</creator><creator>Albertson, Sabrina M</creator><creator>Senjem, Matthew L</creator><creator>Schwarz, Christopher G</creator><creator>Botha, Hugo</creator><creator>Graff-Radford, Jonathan</creator><creator>Jones, David T</creator><creator>Vemuri, Prashanthi</creator><creator>Kantarci, Kejal</creator><creator>Knopman, David S</creator><creator>Petersen, Ronald C</creator><creator>Jack, Jr, Clifford R</creator><creator>Lee, Jeyeon</creator><creator>Lowe, Val J</creator><general>Society of Nuclear Medicine</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20240701</creationdate><title>Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study</title><author>Lecy, Emily E ; 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However, there are discrepancies between which regions contribute to the earliest topographic Aβ deposition within the neocortex.
This study investigated Aβ signals in the perithreshold SUV ratio range using Pittsburgh compound B (PiB) PET in a population-based study cross-sectionally and longitudinally. PiB PET scans from 1,088 participants determined the early patterns of PiB loading in the neocortex.
Early-stage Aβ loading is seen first in the temporal, cingulate, and occipital regions. Regional early deposition patterns are similar in both apolipoprotein ε4 carriers and noncarriers. Clustering analysis shows groups with different patterns of early amyloid deposition.
These findings of initial Aβ deposition patterns may be of significance for diagnostics and understanding the development of Alzheimer disease phenotypes.</abstract><cop>United States</cop><pub>Society of Nuclear Medicine</pub><pmid>38782458</pmid><doi>10.2967/jnumed.123.267150</doi><tpages>7</tpages></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alzheimer's disease Apolipoproteins Cerebral cortex Cluster analysis Clustering Deposition In vivo methods and tests Neocortex Neurodegenerative diseases Phenotypes Population studies Positron emission Regional development β-Amyloid |
| title | Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study |
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