Simultaneous Treatment of 5-Aminosalicylic Acid and Treadmill Exercise More Effectively Improves Ulcerative Colitis in Mice
Ulcerative colitis (UC) is characterized by continuous mucosal ulceration of the colon, starting in the rectum. 5-Aminosalicylic acid (5-ASA) is the main therapy for ulcerative colitis; however, it has side effects. Physical exercise effectively increases the number of anti-inflammatory and anti-imm...
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| Veröffentlicht in: | International journal of molecular sciences 2024-05, Vol.25 (10), p.5076 |
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| description | Ulcerative colitis (UC) is characterized by continuous mucosal ulceration of the colon, starting in the rectum. 5-Aminosalicylic acid (5-ASA) is the main therapy for ulcerative colitis; however, it has side effects. Physical exercise effectively increases the number of anti-inflammatory and anti-immune cells in the body. In the current study, the effects of simultaneous treatment of treadmill exercise and 5-ASA were compared with monotherapy with physical exercise or 5-ASA in UC mice. To induce the UC animal model, the mice consumed 2% dextran sulfate sodium dissolved in drinking water for 7 days. The mice in the exercise groups exercised on a treadmill for 1 h once a day for 14 days after UC induction. The 5-ASA-treated groups received 5-ASA by enema injection using a 200 μL polyethylene catheter once a day for 14 days. Simultaneous treatment improved histological damage and increased body weight, colon weight, and colon length, whereas the disease activity index score and collagen deposition were decreased. Simultaneous treatment with treadmill exercise and 5-ASA suppressed pro-inflammatory cytokines and apoptosis following UC. The benefits of this simultaneous treatment may be due to inhibition on nuclear factor-κB/mitogen-activated protein kinase signaling activation. Based on this study, simultaneous treatment of treadmill exercise and 5-ASA can be considered as a new therapy of UC. |
| doi_str_mv | 10.3390/ijms25105076 |
| format | Article |
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Physical exercise effectively increases the number of anti-inflammatory and anti-immune cells in the body. In the current study, the effects of simultaneous treatment of treadmill exercise and 5-ASA were compared with monotherapy with physical exercise or 5-ASA in UC mice. To induce the UC animal model, the mice consumed 2% dextran sulfate sodium dissolved in drinking water for 7 days. The mice in the exercise groups exercised on a treadmill for 1 h once a day for 14 days after UC induction. The 5-ASA-treated groups received 5-ASA by enema injection using a 200 μL polyethylene catheter once a day for 14 days. Simultaneous treatment improved histological damage and increased body weight, colon weight, and colon length, whereas the disease activity index score and collagen deposition were decreased. Simultaneous treatment with treadmill exercise and 5-ASA suppressed pro-inflammatory cytokines and apoptosis following UC. The benefits of this simultaneous treatment may be due to inhibition on nuclear factor-κB/mitogen-activated protein kinase signaling activation. Based on this study, simultaneous treatment of treadmill exercise and 5-ASA can be considered as a new therapy of UC.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25105076</identifier><identifier>PMID: 38791116</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analysis ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Apoptosis ; Apoptosis - drug effects ; Body weight ; Colitis, Ulcerative - chemically induced ; Colitis, Ulcerative - drug therapy ; Colitis, Ulcerative - pathology ; Colitis, Ulcerative - therapy ; Collagen ; Colon ; Colon - drug effects ; Colon - metabolism ; Colon - pathology ; Crohn's disease ; Cytokines ; Cytokines - metabolism ; Dextran ; Dextran Sulfate ; Disease Models, Animal ; Drinking water ; Exercise ; Experiments ; Fitness equipment ; Homeostasis ; Inflammation ; Inflammatory bowel disease ; Kinases ; Male ; Mesalamine ; Mesalamine - pharmacology ; Mesalamine - therapeutic use ; Mice ; NF-kappa B - metabolism ; Phosphorylation ; Physical Conditioning, Animal ; Protein kinases ; Scientific equipment and supplies industry ; Sulfates ; Tumor necrosis factor-TNF ; Ulcerative colitis</subject><ispartof>International journal of molecular sciences, 2024-05, Vol.25 (10), p.5076</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c381t-630649a33b3e7a9f5494dad9b522fe488048bba1061c4c5b191c4818a3998f733</cites><orcidid>0000-0002-9659-2922 ; 0000-0002-8867-8822 ; 0000-0001-6797-0843 ; 0000-0002-4638-413X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38791116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Jun-Jang</creatorcontrib><creatorcontrib>Ko, Il-Gyu</creatorcontrib><creatorcontrib>Hwang, Lakkyong</creatorcontrib><creatorcontrib>Kim, Sang-Hoon</creatorcontrib><creatorcontrib>Jee, Yong-Seok</creatorcontrib><creatorcontrib>Jeon, Hyeon</creatorcontrib><creatorcontrib>Park, Su Bee</creatorcontrib><creatorcontrib>Jeon, Jung Won</creatorcontrib><title>Simultaneous Treatment of 5-Aminosalicylic Acid and Treadmill Exercise More Effectively Improves Ulcerative Colitis in Mice</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Ulcerative colitis (UC) is characterized by continuous mucosal ulceration of the colon, starting in the rectum. 5-Aminosalicylic acid (5-ASA) is the main therapy for ulcerative colitis; however, it has side effects. Physical exercise effectively increases the number of anti-inflammatory and anti-immune cells in the body. In the current study, the effects of simultaneous treatment of treadmill exercise and 5-ASA were compared with monotherapy with physical exercise or 5-ASA in UC mice. To induce the UC animal model, the mice consumed 2% dextran sulfate sodium dissolved in drinking water for 7 days. The mice in the exercise groups exercised on a treadmill for 1 h once a day for 14 days after UC induction. The 5-ASA-treated groups received 5-ASA by enema injection using a 200 μL polyethylene catheter once a day for 14 days. Simultaneous treatment improved histological damage and increased body weight, colon weight, and colon length, whereas the disease activity index score and collagen deposition were decreased. Simultaneous treatment with treadmill exercise and 5-ASA suppressed pro-inflammatory cytokines and apoptosis following UC. The benefits of this simultaneous treatment may be due to inhibition on nuclear factor-κB/mitogen-activated protein kinase signaling activation. Based on this study, simultaneous treatment of treadmill exercise and 5-ASA can be considered as a new therapy of UC.</description><subject>Analysis</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Body weight</subject><subject>Colitis, Ulcerative - chemically induced</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Colitis, Ulcerative - therapy</subject><subject>Collagen</subject><subject>Colon</subject><subject>Colon - drug effects</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Crohn's disease</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Dextran</subject><subject>Dextran Sulfate</subject><subject>Disease Models, Animal</subject><subject>Drinking water</subject><subject>Exercise</subject><subject>Experiments</subject><subject>Fitness equipment</subject><subject>Homeostasis</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Kinases</subject><subject>Male</subject><subject>Mesalamine</subject><subject>Mesalamine - 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Academic</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Jun-Jang</au><au>Ko, Il-Gyu</au><au>Hwang, Lakkyong</au><au>Kim, Sang-Hoon</au><au>Jee, Yong-Seok</au><au>Jeon, Hyeon</au><au>Park, Su Bee</au><au>Jeon, Jung Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous Treatment of 5-Aminosalicylic Acid and Treadmill Exercise More Effectively Improves Ulcerative Colitis in Mice</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-05-07</date><risdate>2024</risdate><volume>25</volume><issue>10</issue><spage>5076</spage><pages>5076-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Ulcerative colitis (UC) is characterized by continuous mucosal ulceration of the colon, starting in the rectum. 5-Aminosalicylic acid (5-ASA) is the main therapy for ulcerative colitis; however, it has side effects. Physical exercise effectively increases the number of anti-inflammatory and anti-immune cells in the body. In the current study, the effects of simultaneous treatment of treadmill exercise and 5-ASA were compared with monotherapy with physical exercise or 5-ASA in UC mice. To induce the UC animal model, the mice consumed 2% dextran sulfate sodium dissolved in drinking water for 7 days. The mice in the exercise groups exercised on a treadmill for 1 h once a day for 14 days after UC induction. The 5-ASA-treated groups received 5-ASA by enema injection using a 200 μL polyethylene catheter once a day for 14 days. Simultaneous treatment improved histological damage and increased body weight, colon weight, and colon length, whereas the disease activity index score and collagen deposition were decreased. Simultaneous treatment with treadmill exercise and 5-ASA suppressed pro-inflammatory cytokines and apoptosis following UC. The benefits of this simultaneous treatment may be due to inhibition on nuclear factor-κB/mitogen-activated protein kinase signaling activation. Based on this study, simultaneous treatment of treadmill exercise and 5-ASA can be considered as a new therapy of UC.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38791116</pmid><doi>10.3390/ijms25105076</doi><orcidid>https://orcid.org/0000-0002-9659-2922</orcidid><orcidid>https://orcid.org/0000-0002-8867-8822</orcidid><orcidid>https://orcid.org/0000-0001-6797-0843</orcidid><orcidid>https://orcid.org/0000-0002-4638-413X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2024-05, Vol.25 (10), p.5076 |
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| subjects | Analysis Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Apoptosis Apoptosis - drug effects Body weight Colitis, Ulcerative - chemically induced Colitis, Ulcerative - drug therapy Colitis, Ulcerative - pathology Colitis, Ulcerative - therapy Collagen Colon Colon - drug effects Colon - metabolism Colon - pathology Crohn's disease Cytokines Cytokines - metabolism Dextran Dextran Sulfate Disease Models, Animal Drinking water Exercise Experiments Fitness equipment Homeostasis Inflammation Inflammatory bowel disease Kinases Male Mesalamine Mesalamine - pharmacology Mesalamine - therapeutic use Mice NF-kappa B - metabolism Phosphorylation Physical Conditioning, Animal Protein kinases Scientific equipment and supplies industry Sulfates Tumor necrosis factor-TNF Ulcerative colitis |
| title | Simultaneous Treatment of 5-Aminosalicylic Acid and Treadmill Exercise More Effectively Improves Ulcerative Colitis in Mice |
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