C-Phycocyanin Attenuates Noise-Induced Cochlear Synaptopathy via the Inhibition of Oxidative Stress and Intercellular Adhesion Molecule-1 in the Cochlea

The synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are the most vulnerable structures in the noise-exposed cochlea. Cochlear synaptopathy results from the disruption of these synapses following noise exposure and is considered the main cause of poor speech understanding...

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Veröffentlicht in:	International journal of molecular sciences 2024-05, Vol.25 (10), p.5154
Hauptverfasser:	Lin, Yi-Chun, Shih, Cheng-Ping, Lin, Yuan-Yung, Lin, Hung-Che, Kuo, Chao-Yin, Chen, Hang-Kang, Chen, Hsin-Chien, Wang, Chih-Hung
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antioxidants Antioxidants - pharmacology Cell Line Cochlea - drug effects Cochlea - metabolism Cochlea - pathology Cytotoxicity Enzymes Guinea Pigs Hair Cells, Auditory, Inner - drug effects Hair Cells, Auditory, Inner - metabolism Hair Cells, Auditory, Inner - pathology Hearing loss Hearing Loss, Hidden Hearing Loss, Noise-Induced - drug therapy Hearing Loss, Noise-Induced - metabolism Hearing Loss, Noise-Induced - pathology Hearing protection Hydrogen Peroxide - metabolism Intercellular Adhesion Molecule-1 - metabolism Ligaments Lipid peroxidation Male Noise - adverse effects Noise control Oxidative stress Oxidative Stress - drug effects Pathogenesis Phycocyanin - pharmacology Phycocyanin - therapeutic use Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Scientific equipment and supplies industry Spiral Ganglion - drug effects Spiral Ganglion - metabolism Spiral Ganglion - pathology Synapses Synapses - drug effects Synapses - metabolism Toxicity Yang Mu
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