The Impact of Dupilumab on Work Productivity and Emotional Health in CRSwNP: A Multicentric Study in Northeast Italy
Chronic rhinosinusitis with nasal polyps (CRSwNP) in the severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with Dupilumab in different rhinological units were considered for this study...
Gespeichert in:
| Veröffentlicht in: | Journal of personalized medicine 2024-05, Vol.14 (5), p.468 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | 468 |
| container_title | Journal of personalized medicine |
| container_volume | 14 |
| creator | Ottaviano, Giancarlo Roccuzzo, Giuseppe Lora, Lucia Bison, Elisabetta Tosin, Enrico Calvanese, Leonardo Cestaro, Walter Locatello, Luca Giovanni Corlianò, Fabrizio Stellin, Marco Baldovin, Maria Trimarchi, Maria Vittoria Bertocco, Anna Giulia Maculan, Marco Scarpa, Bruno Saccardo, Tommaso Nicolai, Piero |
| description | Chronic rhinosinusitis with nasal polyps (CRSwNP) in the severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with Dupilumab in different rhinological units were considered for this study via their evaluation at the baseline at first and the consequential follow-up at 6-, 12-, and 24 months from the first administration. At baseline (T0) and at each follow-up, patients underwent NPS, Sinonasal Outcome Test (SNOT)-22, Visual Analogue Scale (VAS) for smell, and Sniffin' sticks identification test (SSIT). The SNOT-22 domains for function and emotion were also analysed separately. Two hundred and seventeen patients with at least 6 months of follow-up were included. All parameters have improved during treatment (
< 0.0001). Noticeably, both the function and emotion SNOT-22 domains have improved within 6 months of treatment and have continued to progress during every interval within 12 months from the baseline, positively influencing patients' emotivity and augmenting their social and economic performances. Dupilumab improves the QoL of CRSwNP patients with good effects on the reported productivity and emotional health. Clinicians should pay attention to these two aspects when dealing with patients affected by severe CRSwNP. |
| doi_str_mv | 10.3390/jpm14050468 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_3060371419</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A795387468</galeid><sourcerecordid>A795387468</sourcerecordid><originalsourceid>FETCH-LOGICAL-c309t-da7319fe46aab23ca3fe213ee02195a3a8f8cd4a55c23acf93b2fc20e3ffba8b3</originalsourceid><addsrcrecordid>eNptkU1v1DAQhi0EolXpiTuyxAUJbfFHnMTcVktpVyqlokUco4ljs16cOPgDtP--XrVAQdgHjzzPO5qZF6HnlJxwLsmb7TzSighS1e0jdMhIIxZVxerHD-IDdBzjlpTTCsZq8hQd8LaRnAh6iNLNRuP1OINK2Bv8Ls_W5RF67Cf8xYdv-Cr4Iatkf9i0wzAN-HT0yfoJHD7X4NIG2wmvPl3_vLx6i5f4Q3bJKj2lYBW-TnnY7fOXPqSNhpjwOoHbPUNPDLioj-_fI_T5_enN6nxx8fFsvVpeLBQnMi0GaDiVRlc1QM-4Am40o1xrwqgUwKE1rRoqEEIxDspI3jOjGNHcmB7anh-hV3d15-C_Zx1TN9qotHMwaZ9jx0lNeEMrKgv68h9063MoU-4pIYUoHP9DfQWnOzsZnwKofdFu2UhR1lp8KNTJf6hyBz1a5SdtbPn_S_D6TqCCjzFo083BjhB2HSXd3ubugc2FfnHfau5HPfxmf5nKbwEtOqEv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3059553713</pqid></control><display><type>article</type><title>The Impact of Dupilumab on Work Productivity and Emotional Health in CRSwNP: A Multicentric Study in Northeast Italy</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Ottaviano, Giancarlo ; Roccuzzo, Giuseppe ; Lora, Lucia ; Bison, Elisabetta ; Tosin, Enrico ; Calvanese, Leonardo ; Cestaro, Walter ; Locatello, Luca Giovanni ; Corlianò, Fabrizio ; Stellin, Marco ; Baldovin, Maria ; Trimarchi, Maria Vittoria ; Bertocco, Anna Giulia ; Maculan, Marco ; Scarpa, Bruno ; Saccardo, Tommaso ; Nicolai, Piero</creator><creatorcontrib>Ottaviano, Giancarlo ; Roccuzzo, Giuseppe ; Lora, Lucia ; Bison, Elisabetta ; Tosin, Enrico ; Calvanese, Leonardo ; Cestaro, Walter ; Locatello, Luca Giovanni ; Corlianò, Fabrizio ; Stellin, Marco ; Baldovin, Maria ; Trimarchi, Maria Vittoria ; Bertocco, Anna Giulia ; Maculan, Marco ; Scarpa, Bruno ; Saccardo, Tommaso ; Nicolai, Piero</creatorcontrib><description>Chronic rhinosinusitis with nasal polyps (CRSwNP) in the severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with Dupilumab in different rhinological units were considered for this study via their evaluation at the baseline at first and the consequential follow-up at 6-, 12-, and 24 months from the first administration. At baseline (T0) and at each follow-up, patients underwent NPS, Sinonasal Outcome Test (SNOT)-22, Visual Analogue Scale (VAS) for smell, and Sniffin' sticks identification test (SSIT). The SNOT-22 domains for function and emotion were also analysed separately. Two hundred and seventeen patients with at least 6 months of follow-up were included. All parameters have improved during treatment (
< 0.0001). Noticeably, both the function and emotion SNOT-22 domains have improved within 6 months of treatment and have continued to progress during every interval within 12 months from the baseline, positively influencing patients' emotivity and augmenting their social and economic performances. Dupilumab improves the QoL of CRSwNP patients with good effects on the reported productivity and emotional health. Clinicians should pay attention to these two aspects when dealing with patients affected by severe CRSwNP.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm14050468</identifier><identifier>PMID: 38793051</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Asthma ; Disease ; Emotions ; Endoscopy ; Hospitals ; Inflammation ; Mental health ; Otolaryngology ; Polyps ; Quality of life ; Rhinosinusitis ; Sinuses ; Steroids</subject><ispartof>Journal of personalized medicine, 2024-05, Vol.14 (5), p.468</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c309t-da7319fe46aab23ca3fe213ee02195a3a8f8cd4a55c23acf93b2fc20e3ffba8b3</cites><orcidid>0000-0003-2433-4761 ; 0000-0002-1879-5580 ; 0000-0002-3612-1440 ; 0000-0002-8349-9569 ; 0000-0001-6731-8054</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38793051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ottaviano, Giancarlo</creatorcontrib><creatorcontrib>Roccuzzo, Giuseppe</creatorcontrib><creatorcontrib>Lora, Lucia</creatorcontrib><creatorcontrib>Bison, Elisabetta</creatorcontrib><creatorcontrib>Tosin, Enrico</creatorcontrib><creatorcontrib>Calvanese, Leonardo</creatorcontrib><creatorcontrib>Cestaro, Walter</creatorcontrib><creatorcontrib>Locatello, Luca Giovanni</creatorcontrib><creatorcontrib>Corlianò, Fabrizio</creatorcontrib><creatorcontrib>Stellin, Marco</creatorcontrib><creatorcontrib>Baldovin, Maria</creatorcontrib><creatorcontrib>Trimarchi, Maria Vittoria</creatorcontrib><creatorcontrib>Bertocco, Anna Giulia</creatorcontrib><creatorcontrib>Maculan, Marco</creatorcontrib><creatorcontrib>Scarpa, Bruno</creatorcontrib><creatorcontrib>Saccardo, Tommaso</creatorcontrib><creatorcontrib>Nicolai, Piero</creatorcontrib><title>The Impact of Dupilumab on Work Productivity and Emotional Health in CRSwNP: A Multicentric Study in Northeast Italy</title><title>Journal of personalized medicine</title><addtitle>J Pers Med</addtitle><description>Chronic rhinosinusitis with nasal polyps (CRSwNP) in the severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with Dupilumab in different rhinological units were considered for this study via their evaluation at the baseline at first and the consequential follow-up at 6-, 12-, and 24 months from the first administration. At baseline (T0) and at each follow-up, patients underwent NPS, Sinonasal Outcome Test (SNOT)-22, Visual Analogue Scale (VAS) for smell, and Sniffin' sticks identification test (SSIT). The SNOT-22 domains for function and emotion were also analysed separately. Two hundred and seventeen patients with at least 6 months of follow-up were included. All parameters have improved during treatment (
< 0.0001). Noticeably, both the function and emotion SNOT-22 domains have improved within 6 months of treatment and have continued to progress during every interval within 12 months from the baseline, positively influencing patients' emotivity and augmenting their social and economic performances. Dupilumab improves the QoL of CRSwNP patients with good effects on the reported productivity and emotional health. Clinicians should pay attention to these two aspects when dealing with patients affected by severe CRSwNP.</description><subject>Asthma</subject><subject>Disease</subject><subject>Emotions</subject><subject>Endoscopy</subject><subject>Hospitals</subject><subject>Inflammation</subject><subject>Mental health</subject><subject>Otolaryngology</subject><subject>Polyps</subject><subject>Quality of life</subject><subject>Rhinosinusitis</subject><subject>Sinuses</subject><subject>Steroids</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkU1v1DAQhi0EolXpiTuyxAUJbfFHnMTcVktpVyqlokUco4ljs16cOPgDtP--XrVAQdgHjzzPO5qZF6HnlJxwLsmb7TzSighS1e0jdMhIIxZVxerHD-IDdBzjlpTTCsZq8hQd8LaRnAh6iNLNRuP1OINK2Bv8Ls_W5RF67Cf8xYdv-Cr4Iatkf9i0wzAN-HT0yfoJHD7X4NIG2wmvPl3_vLx6i5f4Q3bJKj2lYBW-TnnY7fOXPqSNhpjwOoHbPUNPDLioj-_fI_T5_enN6nxx8fFsvVpeLBQnMi0GaDiVRlc1QM-4Am40o1xrwqgUwKE1rRoqEEIxDspI3jOjGNHcmB7anh-hV3d15-C_Zx1TN9qotHMwaZ9jx0lNeEMrKgv68h9063MoU-4pIYUoHP9DfQWnOzsZnwKofdFu2UhR1lp8KNTJf6hyBz1a5SdtbPn_S_D6TqCCjzFo083BjhB2HSXd3ubugc2FfnHfau5HPfxmf5nKbwEtOqEv</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Ottaviano, Giancarlo</creator><creator>Roccuzzo, Giuseppe</creator><creator>Lora, Lucia</creator><creator>Bison, Elisabetta</creator><creator>Tosin, Enrico</creator><creator>Calvanese, Leonardo</creator><creator>Cestaro, Walter</creator><creator>Locatello, Luca Giovanni</creator><creator>Corlianò, Fabrizio</creator><creator>Stellin, Marco</creator><creator>Baldovin, Maria</creator><creator>Trimarchi, Maria Vittoria</creator><creator>Bertocco, Anna Giulia</creator><creator>Maculan, Marco</creator><creator>Scarpa, Bruno</creator><creator>Saccardo, Tommaso</creator><creator>Nicolai, Piero</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2433-4761</orcidid><orcidid>https://orcid.org/0000-0002-1879-5580</orcidid><orcidid>https://orcid.org/0000-0002-3612-1440</orcidid><orcidid>https://orcid.org/0000-0002-8349-9569</orcidid><orcidid>https://orcid.org/0000-0001-6731-8054</orcidid></search><sort><creationdate>20240501</creationdate><title>The Impact of Dupilumab on Work Productivity and Emotional Health in CRSwNP: A Multicentric Study in Northeast Italy</title><author>Ottaviano, Giancarlo ; Roccuzzo, Giuseppe ; Lora, Lucia ; Bison, Elisabetta ; Tosin, Enrico ; Calvanese, Leonardo ; Cestaro, Walter ; Locatello, Luca Giovanni ; Corlianò, Fabrizio ; Stellin, Marco ; Baldovin, Maria ; Trimarchi, Maria Vittoria ; Bertocco, Anna Giulia ; Maculan, Marco ; Scarpa, Bruno ; Saccardo, Tommaso ; Nicolai, Piero</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-da7319fe46aab23ca3fe213ee02195a3a8f8cd4a55c23acf93b2fc20e3ffba8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Asthma</topic><topic>Disease</topic><topic>Emotions</topic><topic>Endoscopy</topic><topic>Hospitals</topic><topic>Inflammation</topic><topic>Mental health</topic><topic>Otolaryngology</topic><topic>Polyps</topic><topic>Quality of life</topic><topic>Rhinosinusitis</topic><topic>Sinuses</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ottaviano, Giancarlo</creatorcontrib><creatorcontrib>Roccuzzo, Giuseppe</creatorcontrib><creatorcontrib>Lora, Lucia</creatorcontrib><creatorcontrib>Bison, Elisabetta</creatorcontrib><creatorcontrib>Tosin, Enrico</creatorcontrib><creatorcontrib>Calvanese, Leonardo</creatorcontrib><creatorcontrib>Cestaro, Walter</creatorcontrib><creatorcontrib>Locatello, Luca Giovanni</creatorcontrib><creatorcontrib>Corlianò, Fabrizio</creatorcontrib><creatorcontrib>Stellin, Marco</creatorcontrib><creatorcontrib>Baldovin, Maria</creatorcontrib><creatorcontrib>Trimarchi, Maria Vittoria</creatorcontrib><creatorcontrib>Bertocco, Anna Giulia</creatorcontrib><creatorcontrib>Maculan, Marco</creatorcontrib><creatorcontrib>Scarpa, Bruno</creatorcontrib><creatorcontrib>Saccardo, Tommaso</creatorcontrib><creatorcontrib>Nicolai, Piero</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of personalized medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ottaviano, Giancarlo</au><au>Roccuzzo, Giuseppe</au><au>Lora, Lucia</au><au>Bison, Elisabetta</au><au>Tosin, Enrico</au><au>Calvanese, Leonardo</au><au>Cestaro, Walter</au><au>Locatello, Luca Giovanni</au><au>Corlianò, Fabrizio</au><au>Stellin, Marco</au><au>Baldovin, Maria</au><au>Trimarchi, Maria Vittoria</au><au>Bertocco, Anna Giulia</au><au>Maculan, Marco</au><au>Scarpa, Bruno</au><au>Saccardo, Tommaso</au><au>Nicolai, Piero</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Impact of Dupilumab on Work Productivity and Emotional Health in CRSwNP: A Multicentric Study in Northeast Italy</atitle><jtitle>Journal of personalized medicine</jtitle><addtitle>J Pers Med</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>14</volume><issue>5</issue><spage>468</spage><pages>468-</pages><issn>2075-4426</issn><eissn>2075-4426</eissn><abstract>Chronic rhinosinusitis with nasal polyps (CRSwNP) in the severe forms is associated with a poor quality of life. Dupilumab has been suggested as an add-on treatment option for severe CRSwNP. Severe CRSwNP patients treated with Dupilumab in different rhinological units were considered for this study via their evaluation at the baseline at first and the consequential follow-up at 6-, 12-, and 24 months from the first administration. At baseline (T0) and at each follow-up, patients underwent NPS, Sinonasal Outcome Test (SNOT)-22, Visual Analogue Scale (VAS) for smell, and Sniffin' sticks identification test (SSIT). The SNOT-22 domains for function and emotion were also analysed separately. Two hundred and seventeen patients with at least 6 months of follow-up were included. All parameters have improved during treatment (
< 0.0001). Noticeably, both the function and emotion SNOT-22 domains have improved within 6 months of treatment and have continued to progress during every interval within 12 months from the baseline, positively influencing patients' emotivity and augmenting their social and economic performances. Dupilumab improves the QoL of CRSwNP patients with good effects on the reported productivity and emotional health. Clinicians should pay attention to these two aspects when dealing with patients affected by severe CRSwNP.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38793051</pmid><doi>10.3390/jpm14050468</doi><orcidid>https://orcid.org/0000-0003-2433-4761</orcidid><orcidid>https://orcid.org/0000-0002-1879-5580</orcidid><orcidid>https://orcid.org/0000-0002-3612-1440</orcidid><orcidid>https://orcid.org/0000-0002-8349-9569</orcidid><orcidid>https://orcid.org/0000-0001-6731-8054</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2075-4426 |
| ispartof | Journal of personalized medicine, 2024-05, Vol.14 (5), p.468 |
| issn | 2075-4426 2075-4426 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3060371419 |
| source | PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Asthma Disease Emotions Endoscopy Hospitals Inflammation Mental health Otolaryngology Polyps Quality of life Rhinosinusitis Sinuses Steroids |
| title | The Impact of Dupilumab on Work Productivity and Emotional Health in CRSwNP: A Multicentric Study in Northeast Italy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T07%3A54%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Impact%20of%20Dupilumab%20on%20Work%20Productivity%20and%20Emotional%20Health%20in%20CRSwNP:%20A%20Multicentric%20Study%20in%20Northeast%20Italy&rft.jtitle=Journal%20of%20personalized%20medicine&rft.au=Ottaviano,%20Giancarlo&rft.date=2024-05-01&rft.volume=14&rft.issue=5&rft.spage=468&rft.pages=468-&rft.issn=2075-4426&rft.eissn=2075-4426&rft_id=info:doi/10.3390/jpm14050468&rft_dat=%3Cgale_proqu%3EA795387468%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3059553713&rft_id=info:pmid/38793051&rft_galeid=A795387468&rfr_iscdi=true |