Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass
: Biomarkers development for prognostication or prediction of perioperative myocardial disease is critical for the evolution of treatment options in patients undergoing cardiac surgery. The aim of our prospective monocentric study was to investigate the role of selenoprotein 1 (SEEP 1) as a potentia...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2024-05, Vol.13 (10), p.2943 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 2943 |
| container_title | Journal of clinical medicine |
| container_volume | 13 |
| creator | Serraino, Giuseppe Filiberto Bolignano, Davide Jiritano, Federica Coppolino, Giuseppe Napolitano, Désirée Zicarelli, Mariateresa Pizzini, Patrizia Cutrupi, Sebastiano Testa, Alessandra Spoto, Belinda Andreucci, Michele Mastroroberto, Pasquale Serra, Raffaele |
| description | : Biomarkers development for prognostication or prediction of perioperative myocardial disease is critical for the evolution of treatment options in patients undergoing cardiac surgery. The aim of our prospective monocentric study was to investigate the role of selenoprotein 1 (SEEP 1) as a potential biomarker for assessing the risk of myocardial injury after cardiac surgery.
: Circulating SEPP1 was measured in the blood of 45 patients before surgery and at 4 h, 8 h and 12 h after CPB by enzyme-linked immunosorbent assay (ELISA); (3)
: circulating SEPP-1 levels measured 4 h after surgery were strongly correlated with CK-MB levels measured at 48 h (R = 0.598,
< 0.0001) and at 72 h (R = 0.308,
= 0.05). Close correlations were also found between 4 h SEPP-1 and Hs-c troponin values measured at 24 h (R = 0.532,
< 0.0001), 48 h (R = 0.348,
= 0.01) and 72 h (R = 0.377,
= 0.02), as well as with cardiopulmonary bypass (CPB) (R = 0.389,
= 0.008) and cross-clamp time (R = 0.374,
= 0.001); (4)
: Early SEPP1 measurement after CPB may hold great potential for identifying cardiac surgery patients at risk of developing perioperative myocardial injury. |
| doi_str_mv | 10.3390/jcm13102943 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_3060370803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A795391925</galeid><sourcerecordid>A795391925</sourcerecordid><originalsourceid>FETCH-LOGICAL-c340t-82f894488c191aaab9ad992592e68ad92cc775f5cfee05cc089a2b23ed43ba603</originalsourceid><addsrcrecordid>eNpd0U1P4zAQBmBrxQpQlxP3laW9FK0C_khq-1iq7oIEohJwjqbOpEo3sYudHPLv11X5Er54Do_HY7-EnHN2KaVhV1vbccmZMLn8Rk4FUypjUsujT_UJOYtxy9LSOhdcHZMTqZURuVanJDxii87vgu-xcXSVcTp9XK5W_IJCpODoEkI70uvGdxD-YaC-pvejtxCqBlp667ZDGOn-JPQNuj7SZ1dh2PjGbehir_xuaDvvILHrcQcx_iDfa2gjnr3uE_L8Z_m0uMnuHv7eLuZ3mZU56zMtam3yXGvLDQeAtYHKGFEYgTOdSmGtUkVd2BqRFdYybUCshcQql2uYMTkh00Pf9LiXAWNfdk202Lbg0A-xlCwhxTSTif76Qrd-CC5Nl1Rh8hkvmPlQG2ixbFzt-wB237ScK1NIw9N4Sf0-KBt8jAHrchea9HljyVm5z6z8lFnSP19vHtYdVu_2LSH5H9txj3s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3059461509</pqid></control><display><type>article</type><title>Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Serraino, Giuseppe Filiberto ; Bolignano, Davide ; Jiritano, Federica ; Coppolino, Giuseppe ; Napolitano, Désirée ; Zicarelli, Mariateresa ; Pizzini, Patrizia ; Cutrupi, Sebastiano ; Testa, Alessandra ; Spoto, Belinda ; Andreucci, Michele ; Mastroroberto, Pasquale ; Serra, Raffaele</creator><creatorcontrib>Serraino, Giuseppe Filiberto ; Bolignano, Davide ; Jiritano, Federica ; Coppolino, Giuseppe ; Napolitano, Désirée ; Zicarelli, Mariateresa ; Pizzini, Patrizia ; Cutrupi, Sebastiano ; Testa, Alessandra ; Spoto, Belinda ; Andreucci, Michele ; Mastroroberto, Pasquale ; Serra, Raffaele</creatorcontrib><description>: Biomarkers development for prognostication or prediction of perioperative myocardial disease is critical for the evolution of treatment options in patients undergoing cardiac surgery. The aim of our prospective monocentric study was to investigate the role of selenoprotein 1 (SEEP 1) as a potential biomarker for assessing the risk of myocardial injury after cardiac surgery.
: Circulating SEPP1 was measured in the blood of 45 patients before surgery and at 4 h, 8 h and 12 h after CPB by enzyme-linked immunosorbent assay (ELISA); (3)
: circulating SEPP-1 levels measured 4 h after surgery were strongly correlated with CK-MB levels measured at 48 h (R = 0.598,
< 0.0001) and at 72 h (R = 0.308,
= 0.05). Close correlations were also found between 4 h SEPP-1 and Hs-c troponin values measured at 24 h (R = 0.532,
< 0.0001), 48 h (R = 0.348,
= 0.01) and 72 h (R = 0.377,
= 0.02), as well as with cardiopulmonary bypass (CPB) (R = 0.389,
= 0.008) and cross-clamp time (R = 0.374,
= 0.001); (4)
: Early SEPP1 measurement after CPB may hold great potential for identifying cardiac surgery patients at risk of developing perioperative myocardial injury.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13102943</identifier><identifier>PMID: 38792487</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analysis ; Biological markers ; Biomarkers ; Cardiomyopathy ; Cardiovascular disease ; Carrier proteins ; Complications and side effects ; Coronary artery bypass ; Diagnosis ; Emergency medical care ; Health aspects ; Heart attacks ; Heart diseases ; Heart surgery ; Identification and classification ; Patients ; Risk factors ; Selenium ; Software ; Statistical analysis ; Trends</subject><ispartof>Journal of clinical medicine, 2024-05, Vol.13 (10), p.2943</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c340t-82f894488c191aaab9ad992592e68ad92cc775f5cfee05cc089a2b23ed43ba603</cites><orcidid>0000-0001-8000-0681 ; 0000-0003-3032-245X ; 0009-0008-5522-8738 ; 0000-0002-7974-3792 ; 0000-0002-3060-0520 ; 0000-0002-6889-5686 ; 0000-0003-4477-7412 ; 0000-0002-4804-9570</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38792487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serraino, Giuseppe Filiberto</creatorcontrib><creatorcontrib>Bolignano, Davide</creatorcontrib><creatorcontrib>Jiritano, Federica</creatorcontrib><creatorcontrib>Coppolino, Giuseppe</creatorcontrib><creatorcontrib>Napolitano, Désirée</creatorcontrib><creatorcontrib>Zicarelli, Mariateresa</creatorcontrib><creatorcontrib>Pizzini, Patrizia</creatorcontrib><creatorcontrib>Cutrupi, Sebastiano</creatorcontrib><creatorcontrib>Testa, Alessandra</creatorcontrib><creatorcontrib>Spoto, Belinda</creatorcontrib><creatorcontrib>Andreucci, Michele</creatorcontrib><creatorcontrib>Mastroroberto, Pasquale</creatorcontrib><creatorcontrib>Serra, Raffaele</creatorcontrib><title>Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>: Biomarkers development for prognostication or prediction of perioperative myocardial disease is critical for the evolution of treatment options in patients undergoing cardiac surgery. The aim of our prospective monocentric study was to investigate the role of selenoprotein 1 (SEEP 1) as a potential biomarker for assessing the risk of myocardial injury after cardiac surgery.
: Circulating SEPP1 was measured in the blood of 45 patients before surgery and at 4 h, 8 h and 12 h after CPB by enzyme-linked immunosorbent assay (ELISA); (3)
: circulating SEPP-1 levels measured 4 h after surgery were strongly correlated with CK-MB levels measured at 48 h (R = 0.598,
< 0.0001) and at 72 h (R = 0.308,
= 0.05). Close correlations were also found between 4 h SEPP-1 and Hs-c troponin values measured at 24 h (R = 0.532,
< 0.0001), 48 h (R = 0.348,
= 0.01) and 72 h (R = 0.377,
= 0.02), as well as with cardiopulmonary bypass (CPB) (R = 0.389,
= 0.008) and cross-clamp time (R = 0.374,
= 0.001); (4)
: Early SEPP1 measurement after CPB may hold great potential for identifying cardiac surgery patients at risk of developing perioperative myocardial injury.</description><subject>Analysis</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Carrier proteins</subject><subject>Complications and side effects</subject><subject>Coronary artery bypass</subject><subject>Diagnosis</subject><subject>Emergency medical care</subject><subject>Health aspects</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart surgery</subject><subject>Identification and classification</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Selenium</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Trends</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpd0U1P4zAQBmBrxQpQlxP3laW9FK0C_khq-1iq7oIEohJwjqbOpEo3sYudHPLv11X5Er54Do_HY7-EnHN2KaVhV1vbccmZMLn8Rk4FUypjUsujT_UJOYtxy9LSOhdcHZMTqZURuVanJDxii87vgu-xcXSVcTp9XK5W_IJCpODoEkI70uvGdxD-YaC-pvejtxCqBlp667ZDGOn-JPQNuj7SZ1dh2PjGbehir_xuaDvvILHrcQcx_iDfa2gjnr3uE_L8Z_m0uMnuHv7eLuZ3mZU56zMtam3yXGvLDQeAtYHKGFEYgTOdSmGtUkVd2BqRFdYybUCshcQql2uYMTkh00Pf9LiXAWNfdk202Lbg0A-xlCwhxTSTif76Qrd-CC5Nl1Rh8hkvmPlQG2ixbFzt-wB237ScK1NIw9N4Sf0-KBt8jAHrchea9HljyVm5z6z8lFnSP19vHtYdVu_2LSH5H9txj3s</recordid><startdate>20240516</startdate><enddate>20240516</enddate><creator>Serraino, Giuseppe Filiberto</creator><creator>Bolignano, Davide</creator><creator>Jiritano, Federica</creator><creator>Coppolino, Giuseppe</creator><creator>Napolitano, Désirée</creator><creator>Zicarelli, Mariateresa</creator><creator>Pizzini, Patrizia</creator><creator>Cutrupi, Sebastiano</creator><creator>Testa, Alessandra</creator><creator>Spoto, Belinda</creator><creator>Andreucci, Michele</creator><creator>Mastroroberto, Pasquale</creator><creator>Serra, Raffaele</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8000-0681</orcidid><orcidid>https://orcid.org/0000-0003-3032-245X</orcidid><orcidid>https://orcid.org/0009-0008-5522-8738</orcidid><orcidid>https://orcid.org/0000-0002-7974-3792</orcidid><orcidid>https://orcid.org/0000-0002-3060-0520</orcidid><orcidid>https://orcid.org/0000-0002-6889-5686</orcidid><orcidid>https://orcid.org/0000-0003-4477-7412</orcidid><orcidid>https://orcid.org/0000-0002-4804-9570</orcidid></search><sort><creationdate>20240516</creationdate><title>Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass</title><author>Serraino, Giuseppe Filiberto ; Bolignano, Davide ; Jiritano, Federica ; Coppolino, Giuseppe ; Napolitano, Désirée ; Zicarelli, Mariateresa ; Pizzini, Patrizia ; Cutrupi, Sebastiano ; Testa, Alessandra ; Spoto, Belinda ; Andreucci, Michele ; Mastroroberto, Pasquale ; Serra, Raffaele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-82f894488c191aaab9ad992592e68ad92cc775f5cfee05cc089a2b23ed43ba603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>Carrier proteins</topic><topic>Complications and side effects</topic><topic>Coronary artery bypass</topic><topic>Diagnosis</topic><topic>Emergency medical care</topic><topic>Health aspects</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Heart surgery</topic><topic>Identification and classification</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Selenium</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serraino, Giuseppe Filiberto</creatorcontrib><creatorcontrib>Bolignano, Davide</creatorcontrib><creatorcontrib>Jiritano, Federica</creatorcontrib><creatorcontrib>Coppolino, Giuseppe</creatorcontrib><creatorcontrib>Napolitano, Désirée</creatorcontrib><creatorcontrib>Zicarelli, Mariateresa</creatorcontrib><creatorcontrib>Pizzini, Patrizia</creatorcontrib><creatorcontrib>Cutrupi, Sebastiano</creatorcontrib><creatorcontrib>Testa, Alessandra</creatorcontrib><creatorcontrib>Spoto, Belinda</creatorcontrib><creatorcontrib>Andreucci, Michele</creatorcontrib><creatorcontrib>Mastroroberto, Pasquale</creatorcontrib><creatorcontrib>Serra, Raffaele</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serraino, Giuseppe Filiberto</au><au>Bolignano, Davide</au><au>Jiritano, Federica</au><au>Coppolino, Giuseppe</au><au>Napolitano, Désirée</au><au>Zicarelli, Mariateresa</au><au>Pizzini, Patrizia</au><au>Cutrupi, Sebastiano</au><au>Testa, Alessandra</au><au>Spoto, Belinda</au><au>Andreucci, Michele</au><au>Mastroroberto, Pasquale</au><au>Serra, Raffaele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2024-05-16</date><risdate>2024</risdate><volume>13</volume><issue>10</issue><spage>2943</spage><pages>2943-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>: Biomarkers development for prognostication or prediction of perioperative myocardial disease is critical for the evolution of treatment options in patients undergoing cardiac surgery. The aim of our prospective monocentric study was to investigate the role of selenoprotein 1 (SEEP 1) as a potential biomarker for assessing the risk of myocardial injury after cardiac surgery.
: Circulating SEPP1 was measured in the blood of 45 patients before surgery and at 4 h, 8 h and 12 h after CPB by enzyme-linked immunosorbent assay (ELISA); (3)
: circulating SEPP-1 levels measured 4 h after surgery were strongly correlated with CK-MB levels measured at 48 h (R = 0.598,
< 0.0001) and at 72 h (R = 0.308,
= 0.05). Close correlations were also found between 4 h SEPP-1 and Hs-c troponin values measured at 24 h (R = 0.532,
< 0.0001), 48 h (R = 0.348,
= 0.01) and 72 h (R = 0.377,
= 0.02), as well as with cardiopulmonary bypass (CPB) (R = 0.389,
= 0.008) and cross-clamp time (R = 0.374,
= 0.001); (4)
: Early SEPP1 measurement after CPB may hold great potential for identifying cardiac surgery patients at risk of developing perioperative myocardial injury.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38792487</pmid><doi>10.3390/jcm13102943</doi><orcidid>https://orcid.org/0000-0001-8000-0681</orcidid><orcidid>https://orcid.org/0000-0003-3032-245X</orcidid><orcidid>https://orcid.org/0009-0008-5522-8738</orcidid><orcidid>https://orcid.org/0000-0002-7974-3792</orcidid><orcidid>https://orcid.org/0000-0002-3060-0520</orcidid><orcidid>https://orcid.org/0000-0002-6889-5686</orcidid><orcidid>https://orcid.org/0000-0003-4477-7412</orcidid><orcidid>https://orcid.org/0000-0002-4804-9570</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2024-05, Vol.13 (10), p.2943 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3060370803 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Analysis Biological markers Biomarkers Cardiomyopathy Cardiovascular disease Carrier proteins Complications and side effects Coronary artery bypass Diagnosis Emergency medical care Health aspects Heart attacks Heart diseases Heart surgery Identification and classification Patients Risk factors Selenium Software Statistical analysis Trends |
| title | Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T14%3A36%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Selenoprotein%20P-1%20(SEPP1)%20as%20an%20Early%20Biomarker%20of%20Myocardial%20Injury%20in%20Patients%20Undergoing%20Cardiopulmonary%20Bypass&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Serraino,%20Giuseppe%20Filiberto&rft.date=2024-05-16&rft.volume=13&rft.issue=10&rft.spage=2943&rft.pages=2943-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm13102943&rft_dat=%3Cgale_proqu%3EA795391925%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3059461509&rft_id=info:pmid/38792487&rft_galeid=A795391925&rfr_iscdi=true |