Dual Starvations Induce Pyroptosis for Orthotopic Pancreatic Cancer Therapy through Simultaneous Deprivation of Glucose and Glutamine

Pancreatic cancer is a highly fatal disease, and existing treatment methods are ineffective, so it is urgent to develop new effective treatment strategies. The high dependence of pancreatic cancer cells on glucose and glutamine suggests that disrupting this dependency could serve as an alternative s...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-07, Vol.146 (26), p.17854-17865
Hauptverfasser:	Wang, Xinlong, Ding, Binbin, Liu, Wei, Qi, Lishuang, Li, Jiating, Zheng, Xin, Song, Yiqin, Li, Qiyuan, Wu, Jiawen, Zhang, Meng, Chen, Hua, Wang, Yongwei, Li, Yilong, Sun, Bei, Ma, Ping’an
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System ASC - antagonists & inhibitors Amino Acid Transport System ASC - metabolism Amino Acid Transport System y Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology bioinformatics cancer therapy caspase-1 Cell Line, Tumor glucose Glucose - metabolism Glucose Transporter Type 1 - antagonists & inhibitors Glucose Transporter Type 1 - metabolism glucose transporters glutamine Glutamine - chemistry Glutamine - metabolism glutathione human serum albumin Humans metabolism Minor Histocompatibility Antigens - metabolism nanoparticles Nanoparticles - chemistry nutrition oxidative stress pancreatic neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology pyroptosis Pyroptosis - drug effects reactive oxygen species
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