The mechanism of action of Botrychium (Thunb.) Sw. for prevention of idiopathic pulmonary fibrosis based on 1H-NMR-based metabolomics

This study aimed to reveal the anti-fibrotic effects of Botrychium ternatum (Thunb.) Sw. (BT) against idiopathic pulmonary fibrosis (IPF) and to preliminarily analyze its potential mechanism on bleomycin-induced IPF rats. The inhibition of fibrosis progression in vivo was assessed by histopathology...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2024-08, Vol.76 (8), p.1018-1027
Hauptverfasser:	Lou, Yutao, Zou, Xiaozhou, Pan, Zongfu, Huang, Zhongjie, Zheng, Shuilian, Zheng, Xiaowei, Yang, Xiuli, Bao, Meihua, Zhang, Yuan, Gu, Jinping, Zhang, Yiwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifibrotic Agents - pharmacology Bleomycin Collagen - metabolism Disease Models, Animal Drugs, Chinese Herbal - pharmacology Extracellular Matrix - drug effects Extracellular Matrix - metabolism Hydroxyproline - metabolism Idiopathic Pulmonary Fibrosis - chemically induced Idiopathic Pulmonary Fibrosis - drug therapy Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - prevention & control Ketone Bodies - metabolism Lung - drug effects Lung - metabolism Lung - pathology Male Metabolomics - methods Phenylalanine - pharmacology Plant Extracts - pharmacology Proton Magnetic Resonance Spectroscopy - methods Rats Rats, Sprague-Dawley Transforming Growth Factor beta1 - metabolism Tryptophan - metabolism Tryptophan - pharmacology Tyrosine - analogs & derivatives Tyrosine - metabolism
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