Site-Specific Antimicrobial Activity of a Dual-Responsive Ciprofloxacin Prodrug

Bacterial infections create distinctive microenvironments with a unique mix of metabolites and enzymes compared with healthy tissues that can be used to trigger the activation of antibiotic prodrugs. Here, a single and dual prodrug masking the C3 carboxylate and C7 piperazine of the fluoroquinolone,...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-06, Vol.67 (11), p.9599-9612
Hauptverfasser:	Ross, Catherine L., Lawer, Aggie, Sircombe, Kathleen J., Pletzer, Daniel, Gamble, Allan B., Hook, Sarah
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Ciprofloxacin - pharmacology Escherichia coli - drug effects Female Mice Microbial Sensitivity Tests Nitroreductases - metabolism Prodrugs - chemical synthesis Prodrugs - chemistry Prodrugs - pharmacology Staphylococcus aureus - drug effects
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