The influence of sex, hemoglobin mass, and skeletal muscle characteristics on cycling critical power
Critical power (CP) represents an important threshold for exercise performance and fatiguability. We sought to determine the extent to which sex, hemoglobin mass (Hb ), and skeletal muscle characteristics influence CP. Prior to CP determination (i.e., 3-5 constant work rate trials to task failure),...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2024-07, Vol.137 (1), p.10-22 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Caswell, Allison M Tripp, Thomas R Kontro, Hilkka Edgett, Brittany A Wiley, J Preston Lun, Victor MacInnis, Martin J |
| description | Critical power (CP) represents an important threshold for exercise performance and fatiguability. We sought to determine the extent to which sex, hemoglobin mass (Hb
), and skeletal muscle characteristics influence CP. Prior to CP determination (i.e., 3-5 constant work rate trials to task failure), Hb
and skeletal muscle oxidative capacity (τ) were measured and
muscle biopsy samples were collected from 12 females and 12 males matched for aerobic fitness relative to fat-free mass (mean (SD); V̇O
max: 59.2 (7.7) vs. 59.5 (7.1) mL·kg FFM
·min
, respectively). Males had a significantly greater CP than females in absolute units (225 (28) vs. 170 (43) W; p=0.001) but not relative to body mass (3.0 (0.6) vs. 2.7 (0.6) W·kg BM
; p=0.267) or FFM (3.6 (0.7) vs. 3.7 (0.8) W·kg FFM
; p=0.622). Males had significantly greater W' (p ≤ 0.030) and greater Hb
(p ≤ 0.016) than females, regardless of the normalization approach; however, there were no differences in mitochondrial protein content (p=0.375), τ (p=0.603), or MHC I proportionality (p=0.574) between males and females. Whether it was expressed in absolute or relative units, CP was positively correlated with Hb
(0.444≤r≤0.695; p |
| doi_str_mv | 10.1152/japplphysiol.00120.2024 |
| format | Article |
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), and skeletal muscle characteristics influence CP. Prior to CP determination (i.e., 3-5 constant work rate trials to task failure), Hb
and skeletal muscle oxidative capacity (τ) were measured and
muscle biopsy samples were collected from 12 females and 12 males matched for aerobic fitness relative to fat-free mass (mean (SD); V̇O
max: 59.2 (7.7) vs. 59.5 (7.1) mL·kg FFM
·min
, respectively). Males had a significantly greater CP than females in absolute units (225 (28) vs. 170 (43) W; p=0.001) but not relative to body mass (3.0 (0.6) vs. 2.7 (0.6) W·kg BM
; p=0.267) or FFM (3.6 (0.7) vs. 3.7 (0.8) W·kg FFM
; p=0.622). Males had significantly greater W' (p ≤ 0.030) and greater Hb
(p ≤ 0.016) than females, regardless of the normalization approach; however, there were no differences in mitochondrial protein content (p=0.375), τ (p=0.603), or MHC I proportionality (p=0.574) between males and females. Whether it was expressed in absolute or relative units, CP was positively correlated with Hb
(0.444≤r≤0.695; p<0.05), mitochondrial protein content (0.413≤r≤0.708; p<0.05), and MHC I proportionality (0.506≤r≤0.585; p<0.05), and negatively correlated with τ when expressed in relative units only (-0.588≤r≤-0.527; p<0.05). Overall, CP was independent of sex but variability in CP was related to Hb
and skeletal muscle characteristics. The extent to which manipulations in these physiological parameters influence CP warrants further investigation to better understand factors underpinning CP.</description><identifier>ISSN: 8750-7587</identifier><identifier>ISSN: 1522-1601</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00120.2024</identifier><identifier>PMID: 38779761</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Aerobic capacity ; Biopsy ; Body mass ; Cardiorespiratory fitness ; Fat-free body mass ; Females ; Hemoglobin ; Males ; Muscles ; Musculoskeletal system ; Physiological effects ; Proteins ; Sex ; Skeletal muscle</subject><ispartof>Journal of applied physiology (1985), 2024-07, Vol.137 (1), p.10-22</ispartof><rights>Copyright American Physiological Society Jul 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c217t-4d7f18e4f81d09997444a53bec28ab32a01a30b7b9b14ac71438329a233b7c4b3</cites><orcidid>0000-0002-0377-5800</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38779761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caswell, Allison M</creatorcontrib><creatorcontrib>Tripp, Thomas R</creatorcontrib><creatorcontrib>Kontro, Hilkka</creatorcontrib><creatorcontrib>Edgett, Brittany A</creatorcontrib><creatorcontrib>Wiley, J Preston</creatorcontrib><creatorcontrib>Lun, Victor</creatorcontrib><creatorcontrib>MacInnis, Martin J</creatorcontrib><title>The influence of sex, hemoglobin mass, and skeletal muscle characteristics on cycling critical power</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Critical power (CP) represents an important threshold for exercise performance and fatiguability. We sought to determine the extent to which sex, hemoglobin mass (Hb
), and skeletal muscle characteristics influence CP. Prior to CP determination (i.e., 3-5 constant work rate trials to task failure), Hb
and skeletal muscle oxidative capacity (τ) were measured and
muscle biopsy samples were collected from 12 females and 12 males matched for aerobic fitness relative to fat-free mass (mean (SD); V̇O
max: 59.2 (7.7) vs. 59.5 (7.1) mL·kg FFM
·min
, respectively). Males had a significantly greater CP than females in absolute units (225 (28) vs. 170 (43) W; p=0.001) but not relative to body mass (3.0 (0.6) vs. 2.7 (0.6) W·kg BM
; p=0.267) or FFM (3.6 (0.7) vs. 3.7 (0.8) W·kg FFM
; p=0.622). Males had significantly greater W' (p ≤ 0.030) and greater Hb
(p ≤ 0.016) than females, regardless of the normalization approach; however, there were no differences in mitochondrial protein content (p=0.375), τ (p=0.603), or MHC I proportionality (p=0.574) between males and females. Whether it was expressed in absolute or relative units, CP was positively correlated with Hb
(0.444≤r≤0.695; p<0.05), mitochondrial protein content (0.413≤r≤0.708; p<0.05), and MHC I proportionality (0.506≤r≤0.585; p<0.05), and negatively correlated with τ when expressed in relative units only (-0.588≤r≤-0.527; p<0.05). Overall, CP was independent of sex but variability in CP was related to Hb
and skeletal muscle characteristics. The extent to which manipulations in these physiological parameters influence CP warrants further investigation to better understand factors underpinning CP.</description><subject>Aerobic capacity</subject><subject>Biopsy</subject><subject>Body mass</subject><subject>Cardiorespiratory fitness</subject><subject>Fat-free body mass</subject><subject>Females</subject><subject>Hemoglobin</subject><subject>Males</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Physiological effects</subject><subject>Proteins</subject><subject>Sex</subject><subject>Skeletal muscle</subject><issn>8750-7587</issn><issn>1522-1601</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLxDAQx4Mouj6-gga8eLBrXt2kRxFfIHjRc0nSqZs1bWrSovvtjU_E08DM7z8M80PoiJI5pSU7W-lh8MNynVzwc0IoI3NGmNhAszxlBV0QuolmSpakkKWSO2g3pVXmhCjpNtrhSspKLugMNQ9LwK5v_QS9BRxanODtFC-hC08-GNfjTqd0inXf4PQMHkbtcTcl6wHbpY7ajhBdGp1NOPTYrq13_RO20eVWRofwCnEfbbXaJzj4rnvo8ery4eKmuLu_vr04vysso3IsRCNbqkC0ijakqiophNAlN2CZ0oYzTajmxEhTGSq0lVRwxVmlGedGWmH4Hjr52jvE8DJBGuvOJQve6x7ClGpOyoqVUiiZ0eN_6CpMsc_XZUoJIemiYpmSX5SNIaUIbT1E1-m4rimpP0TUf0XUnyLqDxE5efi9fzIdNL-5n8_zd6SxiCA</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Caswell, Allison M</creator><creator>Tripp, Thomas R</creator><creator>Kontro, Hilkka</creator><creator>Edgett, Brittany A</creator><creator>Wiley, J Preston</creator><creator>Lun, Victor</creator><creator>MacInnis, Martin J</creator><general>American Physiological Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0377-5800</orcidid></search><sort><creationdate>20240701</creationdate><title>The influence of sex, hemoglobin mass, and skeletal muscle characteristics on cycling critical power</title><author>Caswell, Allison M ; Tripp, Thomas R ; Kontro, Hilkka ; Edgett, Brittany A ; Wiley, J Preston ; Lun, Victor ; MacInnis, Martin J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c217t-4d7f18e4f81d09997444a53bec28ab32a01a30b7b9b14ac71438329a233b7c4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aerobic capacity</topic><topic>Biopsy</topic><topic>Body mass</topic><topic>Cardiorespiratory fitness</topic><topic>Fat-free body mass</topic><topic>Females</topic><topic>Hemoglobin</topic><topic>Males</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Physiological effects</topic><topic>Proteins</topic><topic>Sex</topic><topic>Skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caswell, Allison M</creatorcontrib><creatorcontrib>Tripp, Thomas R</creatorcontrib><creatorcontrib>Kontro, Hilkka</creatorcontrib><creatorcontrib>Edgett, Brittany A</creatorcontrib><creatorcontrib>Wiley, J Preston</creatorcontrib><creatorcontrib>Lun, Victor</creatorcontrib><creatorcontrib>MacInnis, Martin J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caswell, Allison M</au><au>Tripp, Thomas R</au><au>Kontro, Hilkka</au><au>Edgett, Brittany A</au><au>Wiley, J Preston</au><au>Lun, Victor</au><au>MacInnis, Martin J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of sex, hemoglobin mass, and skeletal muscle characteristics on cycling critical power</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>137</volume><issue>1</issue><spage>10</spage><epage>22</epage><pages>10-22</pages><issn>8750-7587</issn><issn>1522-1601</issn><eissn>1522-1601</eissn><abstract>Critical power (CP) represents an important threshold for exercise performance and fatiguability. We sought to determine the extent to which sex, hemoglobin mass (Hb
), and skeletal muscle characteristics influence CP. Prior to CP determination (i.e., 3-5 constant work rate trials to task failure), Hb
and skeletal muscle oxidative capacity (τ) were measured and
muscle biopsy samples were collected from 12 females and 12 males matched for aerobic fitness relative to fat-free mass (mean (SD); V̇O
max: 59.2 (7.7) vs. 59.5 (7.1) mL·kg FFM
·min
, respectively). Males had a significantly greater CP than females in absolute units (225 (28) vs. 170 (43) W; p=0.001) but not relative to body mass (3.0 (0.6) vs. 2.7 (0.6) W·kg BM
; p=0.267) or FFM (3.6 (0.7) vs. 3.7 (0.8) W·kg FFM
; p=0.622). Males had significantly greater W' (p ≤ 0.030) and greater Hb
(p ≤ 0.016) than females, regardless of the normalization approach; however, there were no differences in mitochondrial protein content (p=0.375), τ (p=0.603), or MHC I proportionality (p=0.574) between males and females. Whether it was expressed in absolute or relative units, CP was positively correlated with Hb
(0.444≤r≤0.695; p<0.05), mitochondrial protein content (0.413≤r≤0.708; p<0.05), and MHC I proportionality (0.506≤r≤0.585; p<0.05), and negatively correlated with τ when expressed in relative units only (-0.588≤r≤-0.527; p<0.05). Overall, CP was independent of sex but variability in CP was related to Hb
and skeletal muscle characteristics. The extent to which manipulations in these physiological parameters influence CP warrants further investigation to better understand factors underpinning CP.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>38779761</pmid><doi>10.1152/japplphysiol.00120.2024</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0377-5800</orcidid></addata></record> |
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| source | American Physiological Society |
| subjects | Aerobic capacity Biopsy Body mass Cardiorespiratory fitness Fat-free body mass Females Hemoglobin Males Muscles Musculoskeletal system Physiological effects Proteins Sex Skeletal muscle |
| title | The influence of sex, hemoglobin mass, and skeletal muscle characteristics on cycling critical power |
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