Thiosemicarbazone Mixed-Valence Cu(I/II) Complex against Lung Adenocarcinoma Cells through Multiple Pathways Involving Cuproptosis

Induction of cuproptosis and targeting of multiple signaling pathways show promising applications in tumor therapy. In this study, we synthesized two thiosemicarbazone-copper complexes ([CuII(L)Cl] 1 and [CuII 2CuI(L)2Cl3] 2, where HL is the (E)-N-methyl-2-(phenyl(pyridin-2-yl)methylene ligand),...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-06, Vol.67 (11), p.9091-9103
Hauptverfasser:	Li, Aili, Huang, Kai, Pan, Weiping, Wu, Youru, Liang, Yuwei, Zhang, ZhenLei, Wu, Daqi, Ma, Libing, Gou, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adenocarcinoma - drug therapy Adenocarcinoma - pathology Adenocarcinoma of Lung - drug therapy Adenocarcinoma of Lung - pathology Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Line, Tumor Cell Proliferation - drug effects Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - pharmacology Coordination Complexes - therapeutic use Copper - chemistry Drug Screening Assays, Antitumor Hemolysis - drug effects Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Mice Mice, Inbred BALB C Mice, Nude Signal Transduction - drug effects Structure-Activity Relationship Thiosemicarbazones - chemical synthesis Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology Thiosemicarbazones - therapeutic use Xenograft Model Antitumor Assays
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