Low subcutaneous adipose tissue and myosteatosis are prognostic factors after allogeneic hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for several hematological neoplasms. This study aimed to assess the parameters of body composition as predictors of post-transplant overall survival (OS) and adverse events in patients with l...
Gespeichert in:
Veröffentlicht in: | Clinical nutrition ESPEN 2024-06, Vol.61, p.274-280 |
---|---|
Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 280 |
---|---|
container_issue | |
container_start_page | 274 |
container_title | Clinical nutrition ESPEN |
container_volume | 61 |
creator | Barajas Ordonez, Felix Zeller, Yannic Wolleschak, Denise Hinnerichs, Mattes Rodríguez-Feria, Pablo Mougiakakos, Dimitrios Aghayev, Anar Kardas, Hakan Mikusko, Martin Borggrefe, Jan Surov, Alexey |
description | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for several hematological neoplasms. This study aimed to assess the parameters of body composition as predictors of post-transplant overall survival (OS) and adverse events in patients with leukemia, myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN).
This was a retrospective study of 122 adult patients who underwent their first allo-HSCT. The CT-based semi-automated measurement of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), visceral-to-subcutaneous fat ratio (VSR), sarcopenia in terms of skeletal muscle index (SMI), and myosteatosis based on the skeletal muscle radiation attenuation (SM-RA) was performed. Cox regression analysis was used to assess the association of body composition parameters with OS.
In the univariate analysis, low SAT and myosteatosis were associated with lower OS (hazard ratio [HR] 2.02, 95% confidence interval [CI] 1.16–3.51, p = 0.01) and (HR 2.50, 95% CI 1.48–4.25, p =< 0.001), respectively. This association remained significant after adjusting for relevant covariates, with HR 2.32, 95% CI 1.23–4.38, p = 0.01 and HR 2.86, 95% CI 1.51–5.43, p =< 0.001, respectively. On the contrary, VAT, VSR, sarcopenia, and sarcopenic obesity were not statistically significant in OS. Severe post-transplant adverse events were more common in the low SAT group (odds ratio [OR] 3.12, 95% CI 1.32–7.40, p = 0.01) and OR 3.17, 95% CI 1.31–7.70, p =< 0.01 in the age- and sex-adjusted analysis.
Low SAT and myosteatosis may contribute to an increased risk of post-transplant mortality, while low SAT appears to increase the risk of severe post-transplant adverse events. |
doi_str_mv | 10.1016/j.clnesp.2024.03.032 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3059255258</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2405457724000871</els_id><sourcerecordid>3059255258</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-2b5d06ac40135abd4cc13c25d87916e2898b1677bb0d21e4da0efabf67fcea0f3</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVJaUK6_6AUHXPZjT4t-1IIIWkDC7mkZyFL41SLLbmSnJJbf3q1OAk9BQYkZp53Pl6EvlCyo4Q2l4edHQPkeccIEzvCa7AP6IwJIrdCKnXy3_8UbXI-EFJ1XSco-YROeauUEoKfob_7-AfnpbdLMQHikrFxfo4ZcPE5L4BNcHh6jrmAKTH7Wk-A5xQfQ815iwdjS0w1PRRI2IxjfIQAtfALpqqYo4cjVvUTtjCOuCQT8jyaUEzxMXxGHwczZti8vOfo5-3Nw_WP7f7--9311X5ruVRly3rpSGOsIJRL0zthLeWWSdeqjjbA2q7taaNU3xPHKAhnCAymHxo1WDBk4OfoYu1bd_-9QC568vm40Hq25kR2TEom24qKFbUp5pxg0HPyk0nPmhJ9tF8f9Gq_PtqvCa_Bquzry4Sln8C9iV7NrsC3FYB655OHpLP1ECw4n8AW7aJ_f8I_Xh6cug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3059255258</pqid></control><display><type>article</type><title>Low subcutaneous adipose tissue and myosteatosis are prognostic factors after allogeneic hematopoietic stem cell transplantation</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Barajas Ordonez, Felix ; Zeller, Yannic ; Wolleschak, Denise ; Hinnerichs, Mattes ; Rodríguez-Feria, Pablo ; Mougiakakos, Dimitrios ; Aghayev, Anar ; Kardas, Hakan ; Mikusko, Martin ; Borggrefe, Jan ; Surov, Alexey</creator><creatorcontrib>Barajas Ordonez, Felix ; Zeller, Yannic ; Wolleschak, Denise ; Hinnerichs, Mattes ; Rodríguez-Feria, Pablo ; Mougiakakos, Dimitrios ; Aghayev, Anar ; Kardas, Hakan ; Mikusko, Martin ; Borggrefe, Jan ; Surov, Alexey</creatorcontrib><description>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for several hematological neoplasms. This study aimed to assess the parameters of body composition as predictors of post-transplant overall survival (OS) and adverse events in patients with leukemia, myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN).
This was a retrospective study of 122 adult patients who underwent their first allo-HSCT. The CT-based semi-automated measurement of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), visceral-to-subcutaneous fat ratio (VSR), sarcopenia in terms of skeletal muscle index (SMI), and myosteatosis based on the skeletal muscle radiation attenuation (SM-RA) was performed. Cox regression analysis was used to assess the association of body composition parameters with OS.
In the univariate analysis, low SAT and myosteatosis were associated with lower OS (hazard ratio [HR] 2.02, 95% confidence interval [CI] 1.16–3.51, p = 0.01) and (HR 2.50, 95% CI 1.48–4.25, p =< 0.001), respectively. This association remained significant after adjusting for relevant covariates, with HR 2.32, 95% CI 1.23–4.38, p = 0.01 and HR 2.86, 95% CI 1.51–5.43, p =< 0.001, respectively. On the contrary, VAT, VSR, sarcopenia, and sarcopenic obesity were not statistically significant in OS. Severe post-transplant adverse events were more common in the low SAT group (odds ratio [OR] 3.12, 95% CI 1.32–7.40, p = 0.01) and OR 3.17, 95% CI 1.31–7.70, p =< 0.01 in the age- and sex-adjusted analysis.
Low SAT and myosteatosis may contribute to an increased risk of post-transplant mortality, while low SAT appears to increase the risk of severe post-transplant adverse events.</description><identifier>ISSN: 2405-4577</identifier><identifier>EISSN: 2405-4577</identifier><identifier>DOI: 10.1016/j.clnesp.2024.03.032</identifier><identifier>PMID: 38777443</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adipose tissue ; Adult ; Aged ; Body Composition ; Female ; Hematological neoplasms ; Hematopoietic Stem Cell Transplantation ; Humans ; Intra-Abdominal Fat ; Male ; Middle Aged ; Muscle, Skeletal ; Prognosis ; Retrospective Studies ; Sarcopenia ; Stem cell transplantation ; Subcutaneous Fat ; Tomography ; Transplantation, Homologous ; X-ray computed ; Young Adult</subject><ispartof>Clinical nutrition ESPEN, 2024-06, Vol.61, p.274-280</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c357t-2b5d06ac40135abd4cc13c25d87916e2898b1677bb0d21e4da0efabf67fcea0f3</cites><orcidid>0009-0002-7565-3973 ; 0000-0002-2963-2138 ; 0000-0001-9289-6761 ; 0000-0002-0362-3612 ; 0000-0003-2908-7560 ; 0000-0002-9273-3943</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38777443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barajas Ordonez, Felix</creatorcontrib><creatorcontrib>Zeller, Yannic</creatorcontrib><creatorcontrib>Wolleschak, Denise</creatorcontrib><creatorcontrib>Hinnerichs, Mattes</creatorcontrib><creatorcontrib>Rodríguez-Feria, Pablo</creatorcontrib><creatorcontrib>Mougiakakos, Dimitrios</creatorcontrib><creatorcontrib>Aghayev, Anar</creatorcontrib><creatorcontrib>Kardas, Hakan</creatorcontrib><creatorcontrib>Mikusko, Martin</creatorcontrib><creatorcontrib>Borggrefe, Jan</creatorcontrib><creatorcontrib>Surov, Alexey</creatorcontrib><title>Low subcutaneous adipose tissue and myosteatosis are prognostic factors after allogeneic hematopoietic stem cell transplantation</title><title>Clinical nutrition ESPEN</title><addtitle>Clin Nutr ESPEN</addtitle><description>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for several hematological neoplasms. This study aimed to assess the parameters of body composition as predictors of post-transplant overall survival (OS) and adverse events in patients with leukemia, myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN).
This was a retrospective study of 122 adult patients who underwent their first allo-HSCT. The CT-based semi-automated measurement of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), visceral-to-subcutaneous fat ratio (VSR), sarcopenia in terms of skeletal muscle index (SMI), and myosteatosis based on the skeletal muscle radiation attenuation (SM-RA) was performed. Cox regression analysis was used to assess the association of body composition parameters with OS.
In the univariate analysis, low SAT and myosteatosis were associated with lower OS (hazard ratio [HR] 2.02, 95% confidence interval [CI] 1.16–3.51, p = 0.01) and (HR 2.50, 95% CI 1.48–4.25, p =< 0.001), respectively. This association remained significant after adjusting for relevant covariates, with HR 2.32, 95% CI 1.23–4.38, p = 0.01 and HR 2.86, 95% CI 1.51–5.43, p =< 0.001, respectively. On the contrary, VAT, VSR, sarcopenia, and sarcopenic obesity were not statistically significant in OS. Severe post-transplant adverse events were more common in the low SAT group (odds ratio [OR] 3.12, 95% CI 1.32–7.40, p = 0.01) and OR 3.17, 95% CI 1.31–7.70, p =< 0.01 in the age- and sex-adjusted analysis.
Low SAT and myosteatosis may contribute to an increased risk of post-transplant mortality, while low SAT appears to increase the risk of severe post-transplant adverse events.</description><subject>Adipose tissue</subject><subject>Adult</subject><subject>Aged</subject><subject>Body Composition</subject><subject>Female</subject><subject>Hematological neoplasms</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Humans</subject><subject>Intra-Abdominal Fat</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sarcopenia</subject><subject>Stem cell transplantation</subject><subject>Subcutaneous Fat</subject><subject>Tomography</subject><subject>Transplantation, Homologous</subject><subject>X-ray computed</subject><subject>Young Adult</subject><issn>2405-4577</issn><issn>2405-4577</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVJaUK6_6AUHXPZjT4t-1IIIWkDC7mkZyFL41SLLbmSnJJbf3q1OAk9BQYkZp53Pl6EvlCyo4Q2l4edHQPkeccIEzvCa7AP6IwJIrdCKnXy3_8UbXI-EFJ1XSco-YROeauUEoKfob_7-AfnpbdLMQHikrFxfo4ZcPE5L4BNcHh6jrmAKTH7Wk-A5xQfQ815iwdjS0w1PRRI2IxjfIQAtfALpqqYo4cjVvUTtjCOuCQT8jyaUEzxMXxGHwczZti8vOfo5-3Nw_WP7f7--9311X5ruVRly3rpSGOsIJRL0zthLeWWSdeqjjbA2q7taaNU3xPHKAhnCAymHxo1WDBk4OfoYu1bd_-9QC568vm40Hq25kR2TEom24qKFbUp5pxg0HPyk0nPmhJ9tF8f9Gq_PtqvCa_Bquzry4Sln8C9iV7NrsC3FYB655OHpLP1ECw4n8AW7aJ_f8I_Xh6cug</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Barajas Ordonez, Felix</creator><creator>Zeller, Yannic</creator><creator>Wolleschak, Denise</creator><creator>Hinnerichs, Mattes</creator><creator>Rodríguez-Feria, Pablo</creator><creator>Mougiakakos, Dimitrios</creator><creator>Aghayev, Anar</creator><creator>Kardas, Hakan</creator><creator>Mikusko, Martin</creator><creator>Borggrefe, Jan</creator><creator>Surov, Alexey</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0002-7565-3973</orcidid><orcidid>https://orcid.org/0000-0002-2963-2138</orcidid><orcidid>https://orcid.org/0000-0001-9289-6761</orcidid><orcidid>https://orcid.org/0000-0002-0362-3612</orcidid><orcidid>https://orcid.org/0000-0003-2908-7560</orcidid><orcidid>https://orcid.org/0000-0002-9273-3943</orcidid></search><sort><creationdate>202406</creationdate><title>Low subcutaneous adipose tissue and myosteatosis are prognostic factors after allogeneic hematopoietic stem cell transplantation</title><author>Barajas Ordonez, Felix ; Zeller, Yannic ; Wolleschak, Denise ; Hinnerichs, Mattes ; Rodríguez-Feria, Pablo ; Mougiakakos, Dimitrios ; Aghayev, Anar ; Kardas, Hakan ; Mikusko, Martin ; Borggrefe, Jan ; Surov, Alexey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-2b5d06ac40135abd4cc13c25d87916e2898b1677bb0d21e4da0efabf67fcea0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adipose tissue</topic><topic>Adult</topic><topic>Aged</topic><topic>Body Composition</topic><topic>Female</topic><topic>Hematological neoplasms</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Humans</topic><topic>Intra-Abdominal Fat</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sarcopenia</topic><topic>Stem cell transplantation</topic><topic>Subcutaneous Fat</topic><topic>Tomography</topic><topic>Transplantation, Homologous</topic><topic>X-ray computed</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barajas Ordonez, Felix</creatorcontrib><creatorcontrib>Zeller, Yannic</creatorcontrib><creatorcontrib>Wolleschak, Denise</creatorcontrib><creatorcontrib>Hinnerichs, Mattes</creatorcontrib><creatorcontrib>Rodríguez-Feria, Pablo</creatorcontrib><creatorcontrib>Mougiakakos, Dimitrios</creatorcontrib><creatorcontrib>Aghayev, Anar</creatorcontrib><creatorcontrib>Kardas, Hakan</creatorcontrib><creatorcontrib>Mikusko, Martin</creatorcontrib><creatorcontrib>Borggrefe, Jan</creatorcontrib><creatorcontrib>Surov, Alexey</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition ESPEN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barajas Ordonez, Felix</au><au>Zeller, Yannic</au><au>Wolleschak, Denise</au><au>Hinnerichs, Mattes</au><au>Rodríguez-Feria, Pablo</au><au>Mougiakakos, Dimitrios</au><au>Aghayev, Anar</au><au>Kardas, Hakan</au><au>Mikusko, Martin</au><au>Borggrefe, Jan</au><au>Surov, Alexey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low subcutaneous adipose tissue and myosteatosis are prognostic factors after allogeneic hematopoietic stem cell transplantation</atitle><jtitle>Clinical nutrition ESPEN</jtitle><addtitle>Clin Nutr ESPEN</addtitle><date>2024-06</date><risdate>2024</risdate><volume>61</volume><spage>274</spage><epage>280</epage><pages>274-280</pages><issn>2405-4577</issn><eissn>2405-4577</eissn><abstract>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment option for several hematological neoplasms. This study aimed to assess the parameters of body composition as predictors of post-transplant overall survival (OS) and adverse events in patients with leukemia, myelodysplastic syndromes (MDS), and myeloproliferative neoplasms (MPN).
This was a retrospective study of 122 adult patients who underwent their first allo-HSCT. The CT-based semi-automated measurement of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), visceral-to-subcutaneous fat ratio (VSR), sarcopenia in terms of skeletal muscle index (SMI), and myosteatosis based on the skeletal muscle radiation attenuation (SM-RA) was performed. Cox regression analysis was used to assess the association of body composition parameters with OS.
In the univariate analysis, low SAT and myosteatosis were associated with lower OS (hazard ratio [HR] 2.02, 95% confidence interval [CI] 1.16–3.51, p = 0.01) and (HR 2.50, 95% CI 1.48–4.25, p =< 0.001), respectively. This association remained significant after adjusting for relevant covariates, with HR 2.32, 95% CI 1.23–4.38, p = 0.01 and HR 2.86, 95% CI 1.51–5.43, p =< 0.001, respectively. On the contrary, VAT, VSR, sarcopenia, and sarcopenic obesity were not statistically significant in OS. Severe post-transplant adverse events were more common in the low SAT group (odds ratio [OR] 3.12, 95% CI 1.32–7.40, p = 0.01) and OR 3.17, 95% CI 1.31–7.70, p =< 0.01 in the age- and sex-adjusted analysis.
Low SAT and myosteatosis may contribute to an increased risk of post-transplant mortality, while low SAT appears to increase the risk of severe post-transplant adverse events.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38777443</pmid><doi>10.1016/j.clnesp.2024.03.032</doi><tpages>7</tpages><orcidid>https://orcid.org/0009-0002-7565-3973</orcidid><orcidid>https://orcid.org/0000-0002-2963-2138</orcidid><orcidid>https://orcid.org/0000-0001-9289-6761</orcidid><orcidid>https://orcid.org/0000-0002-0362-3612</orcidid><orcidid>https://orcid.org/0000-0003-2908-7560</orcidid><orcidid>https://orcid.org/0000-0002-9273-3943</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2405-4577 |
ispartof | Clinical nutrition ESPEN, 2024-06, Vol.61, p.274-280 |
issn | 2405-4577 2405-4577 |
language | eng |
recordid | cdi_proquest_miscellaneous_3059255258 |
source | MEDLINE; Alma/SFX Local Collection |
subjects | Adipose tissue Adult Aged Body Composition Female Hematological neoplasms Hematopoietic Stem Cell Transplantation Humans Intra-Abdominal Fat Male Middle Aged Muscle, Skeletal Prognosis Retrospective Studies Sarcopenia Stem cell transplantation Subcutaneous Fat Tomography Transplantation, Homologous X-ray computed Young Adult |
title | Low subcutaneous adipose tissue and myosteatosis are prognostic factors after allogeneic hematopoietic stem cell transplantation |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A02%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20subcutaneous%20adipose%20tissue%20and%20myosteatosis%20are%20prognostic%20factors%20after%20allogeneic%20hematopoietic%20stem%20cell%20transplantation&rft.jtitle=Clinical%20nutrition%20ESPEN&rft.au=Barajas%20Ordonez,%20Felix&rft.date=2024-06&rft.volume=61&rft.spage=274&rft.epage=280&rft.pages=274-280&rft.issn=2405-4577&rft.eissn=2405-4577&rft_id=info:doi/10.1016/j.clnesp.2024.03.032&rft_dat=%3Cproquest_cross%3E3059255258%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3059255258&rft_id=info:pmid/38777443&rft_els_id=S2405457724000871&rfr_iscdi=true |