Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality
Purpose In our previous study, we confirmed that the supplementation of vitrified-warmed murine oocytes with autologous adipose stem cell (ASC)-derived mitochondria during intracytoplasmic sperm injection enhances post-fertilization developmental competence in mice. To ensure the safety of this tech...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2024-08, Vol.41 (8), p.2065-2077 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Kankanam Gamage, Sanath Udayanga Hashimoto, Shu Miyamoto, Yuki Nakano, Tatsuya Yamanaka, Masaya Kitaji, Hideki Takada, Yuki Matsumoto, Hiroshi Koike, Akiko Satoh, Manabu Ichishi, Masako Watanabe, Masatoshi Morimoto, Yoshiharu |
| description | Purpose
In our previous study, we confirmed that the supplementation of vitrified-warmed murine oocytes with autologous adipose stem cell (ASC)-derived mitochondria during intracytoplasmic sperm injection enhances post-fertilization developmental competence in mice. To ensure the safety of this technology, we conducted a thorough study in mice to investigate the potential presence of specific malformations in offspring developed from this approach.
Methods
A transgenerational comparative analysis was conducted on founder mice from embryos that developed after mitochondrial supplementation, and two subsequent generations. Reproductive performance, body growth rate, histopathological parameters, hematological parameters, daily activity patterns, and daily body temperature changes in male and female mice across these three generations were assessed in comparison to wild-type mice of the same age.
Results
Both male and female animals in all three generations showed comparable reproductive performance to the control group. Additionally, body growth rate by the age of 8 weeks were found to be comparable to controls across all three generations. Notably, no significant histopathological abnormalities were detected in vital organs, including the brain, heart, liver, kidneys, lungs, ovaries, and testes, in any individuals from the studied cohorts. The blood parameters were consistent with the control data. The continuous monitoring of activity and body temperature changes (both day and night) over a 1-week period revealed a pattern closely resembling that observed in the control animals.
Conclusion
Injection of ASC-mitochondria into oocytes may be a promising technique to support developmental potential without causing adverse epigenetic events in the offspring in mice. However, before considering clinical application, additional safety screening using larger animals or non-human primates is essential. |
| doi_str_mv | 10.1007/s10815-024-03137-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3059254816</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3059254816</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-b0cced78e55649cc1d3486231fd345df27648c25932ba20570fba7ba464f585a3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSNERUvhBVggS2zYGPwbO0tU8VOpEgvK2nLsya2rxE5tp-i-QR8bX24BiQWrGXm-Mz6j03WvKHlHCVHvCyWaSkyYwIRTrjB70p1RqThWnJOnrSdSYyJ6fdo9L-WWEDJoxp91p1wrpYaennUP37Z1nWGBWG0NKaIfod4gu9U0p13aCrI-rKkAKhUW5GCesYcc7sGjJdTkblL0OVjkbEQjIIuKnVqJHq05LaGEuGvSbCvs9mhKGYWlDe4Pzym5fQV0t9k51P2L7mSyc4GXj_W8-_7p4_XFF3z19fPlxYcr7DjrKx6Jc-CVBil7MThHPRe6Z5xOrZF-YqoX2jE5cDZaRqQi02jVaEUvJqml5efd2-PeZuNug1JNc3m4y0Zo9xpO5MCk0LRv6Jt_0Nu05djcNWqQTGtKRaPYkXI5lZJhMmsOi817Q4k55GSOOZmWk_mVk2FN9Ppx9TYu4P9IfgfTAH4EShvFHeS_f_9n7U961aA2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3095288114</pqid></control><display><type>article</type><title>Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kankanam Gamage, Sanath Udayanga ; Hashimoto, Shu ; Miyamoto, Yuki ; Nakano, Tatsuya ; Yamanaka, Masaya ; Kitaji, Hideki ; Takada, Yuki ; Matsumoto, Hiroshi ; Koike, Akiko ; Satoh, Manabu ; Ichishi, Masako ; Watanabe, Masatoshi ; Morimoto, Yoshiharu</creator><creatorcontrib>Kankanam Gamage, Sanath Udayanga ; Hashimoto, Shu ; Miyamoto, Yuki ; Nakano, Tatsuya ; Yamanaka, Masaya ; Kitaji, Hideki ; Takada, Yuki ; Matsumoto, Hiroshi ; Koike, Akiko ; Satoh, Manabu ; Ichishi, Masako ; Watanabe, Masatoshi ; Morimoto, Yoshiharu</creatorcontrib><description>Purpose
In our previous study, we confirmed that the supplementation of vitrified-warmed murine oocytes with autologous adipose stem cell (ASC)-derived mitochondria during intracytoplasmic sperm injection enhances post-fertilization developmental competence in mice. To ensure the safety of this technology, we conducted a thorough study in mice to investigate the potential presence of specific malformations in offspring developed from this approach.
Methods
A transgenerational comparative analysis was conducted on founder mice from embryos that developed after mitochondrial supplementation, and two subsequent generations. Reproductive performance, body growth rate, histopathological parameters, hematological parameters, daily activity patterns, and daily body temperature changes in male and female mice across these three generations were assessed in comparison to wild-type mice of the same age.
Results
Both male and female animals in all three generations showed comparable reproductive performance to the control group. Additionally, body growth rate by the age of 8 weeks were found to be comparable to controls across all three generations. Notably, no significant histopathological abnormalities were detected in vital organs, including the brain, heart, liver, kidneys, lungs, ovaries, and testes, in any individuals from the studied cohorts. The blood parameters were consistent with the control data. The continuous monitoring of activity and body temperature changes (both day and night) over a 1-week period revealed a pattern closely resembling that observed in the control animals.
Conclusion
Injection of ASC-mitochondria into oocytes may be a promising technique to support developmental potential without causing adverse epigenetic events in the offspring in mice. However, before considering clinical application, additional safety screening using larger animals or non-human primates is essential.</description><identifier>ISSN: 1058-0468</identifier><identifier>ISSN: 1573-7330</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-024-03137-2</identifier><identifier>PMID: 38777961</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Activity patterns ; Adipose Tissue - cytology ; Animals ; Body temperature ; Comparative analysis ; Cryopreservation - methods ; Embryos ; Epigenetics ; Female ; Fertilization ; Gamete Biology ; Growth rate ; Gynecology ; Human Genetics ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mice ; Mitochondria ; Mitochondria - metabolism ; Offspring ; Oocytes ; Oocytes - growth & development ; Reproductive Medicine ; Sperm Injections, Intracytoplasmic - methods ; Stem cells ; Stem Cells - cytology ; Stem Cells - metabolism ; Supplements</subject><ispartof>Journal of assisted reproduction and genetics, 2024-08, Vol.41 (8), p.2065-2077</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-b0cced78e55649cc1d3486231fd345df27648c25932ba20570fba7ba464f585a3</cites><orcidid>0000-0003-2834-2726 ; 0000-0002-2198-1069 ; 0000-0001-9083-1403 ; 0000-0002-9423-0901 ; 0000-0003-4710-3448</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10815-024-03137-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10815-024-03137-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38777961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kankanam Gamage, Sanath Udayanga</creatorcontrib><creatorcontrib>Hashimoto, Shu</creatorcontrib><creatorcontrib>Miyamoto, Yuki</creatorcontrib><creatorcontrib>Nakano, Tatsuya</creatorcontrib><creatorcontrib>Yamanaka, Masaya</creatorcontrib><creatorcontrib>Kitaji, Hideki</creatorcontrib><creatorcontrib>Takada, Yuki</creatorcontrib><creatorcontrib>Matsumoto, Hiroshi</creatorcontrib><creatorcontrib>Koike, Akiko</creatorcontrib><creatorcontrib>Satoh, Manabu</creatorcontrib><creatorcontrib>Ichishi, Masako</creatorcontrib><creatorcontrib>Watanabe, Masatoshi</creatorcontrib><creatorcontrib>Morimoto, Yoshiharu</creatorcontrib><title>Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
In our previous study, we confirmed that the supplementation of vitrified-warmed murine oocytes with autologous adipose stem cell (ASC)-derived mitochondria during intracytoplasmic sperm injection enhances post-fertilization developmental competence in mice. To ensure the safety of this technology, we conducted a thorough study in mice to investigate the potential presence of specific malformations in offspring developed from this approach.
Methods
A transgenerational comparative analysis was conducted on founder mice from embryos that developed after mitochondrial supplementation, and two subsequent generations. Reproductive performance, body growth rate, histopathological parameters, hematological parameters, daily activity patterns, and daily body temperature changes in male and female mice across these three generations were assessed in comparison to wild-type mice of the same age.
Results
Both male and female animals in all three generations showed comparable reproductive performance to the control group. Additionally, body growth rate by the age of 8 weeks were found to be comparable to controls across all three generations. Notably, no significant histopathological abnormalities were detected in vital organs, including the brain, heart, liver, kidneys, lungs, ovaries, and testes, in any individuals from the studied cohorts. The blood parameters were consistent with the control data. The continuous monitoring of activity and body temperature changes (both day and night) over a 1-week period revealed a pattern closely resembling that observed in the control animals.
Conclusion
Injection of ASC-mitochondria into oocytes may be a promising technique to support developmental potential without causing adverse epigenetic events in the offspring in mice. However, before considering clinical application, additional safety screening using larger animals or non-human primates is essential.</description><subject>Activity patterns</subject><subject>Adipose Tissue - cytology</subject><subject>Animals</subject><subject>Body temperature</subject><subject>Comparative analysis</subject><subject>Cryopreservation - methods</subject><subject>Embryos</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Fertilization</subject><subject>Gamete Biology</subject><subject>Growth rate</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Offspring</subject><subject>Oocytes</subject><subject>Oocytes - growth & development</subject><subject>Reproductive Medicine</subject><subject>Sperm Injections, Intracytoplasmic - methods</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Supplements</subject><issn>1058-0468</issn><issn>1573-7330</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhSNERUvhBVggS2zYGPwbO0tU8VOpEgvK2nLsya2rxE5tp-i-QR8bX24BiQWrGXm-Mz6j03WvKHlHCVHvCyWaSkyYwIRTrjB70p1RqThWnJOnrSdSYyJ6fdo9L-WWEDJoxp91p1wrpYaennUP37Z1nWGBWG0NKaIfod4gu9U0p13aCrI-rKkAKhUW5GCesYcc7sGjJdTkblL0OVjkbEQjIIuKnVqJHq05LaGEuGvSbCvs9mhKGYWlDe4Pzym5fQV0t9k51P2L7mSyc4GXj_W8-_7p4_XFF3z19fPlxYcr7DjrKx6Jc-CVBil7MThHPRe6Z5xOrZF-YqoX2jE5cDZaRqQi02jVaEUvJqml5efd2-PeZuNug1JNc3m4y0Zo9xpO5MCk0LRv6Jt_0Nu05djcNWqQTGtKRaPYkXI5lZJhMmsOi817Q4k55GSOOZmWk_mVk2FN9Ppx9TYu4P9IfgfTAH4EShvFHeS_f_9n7U961aA2</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Kankanam Gamage, Sanath Udayanga</creator><creator>Hashimoto, Shu</creator><creator>Miyamoto, Yuki</creator><creator>Nakano, Tatsuya</creator><creator>Yamanaka, Masaya</creator><creator>Kitaji, Hideki</creator><creator>Takada, Yuki</creator><creator>Matsumoto, Hiroshi</creator><creator>Koike, Akiko</creator><creator>Satoh, Manabu</creator><creator>Ichishi, Masako</creator><creator>Watanabe, Masatoshi</creator><creator>Morimoto, Yoshiharu</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2834-2726</orcidid><orcidid>https://orcid.org/0000-0002-2198-1069</orcidid><orcidid>https://orcid.org/0000-0001-9083-1403</orcidid><orcidid>https://orcid.org/0000-0002-9423-0901</orcidid><orcidid>https://orcid.org/0000-0003-4710-3448</orcidid></search><sort><creationdate>20240801</creationdate><title>Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality</title><author>Kankanam Gamage, Sanath Udayanga ; Hashimoto, Shu ; Miyamoto, Yuki ; Nakano, Tatsuya ; Yamanaka, Masaya ; Kitaji, Hideki ; Takada, Yuki ; Matsumoto, Hiroshi ; Koike, Akiko ; Satoh, Manabu ; Ichishi, Masako ; Watanabe, Masatoshi ; Morimoto, Yoshiharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-b0cced78e55649cc1d3486231fd345df27648c25932ba20570fba7ba464f585a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Activity patterns</topic><topic>Adipose Tissue - cytology</topic><topic>Animals</topic><topic>Body temperature</topic><topic>Comparative analysis</topic><topic>Cryopreservation - methods</topic><topic>Embryos</topic><topic>Epigenetics</topic><topic>Female</topic><topic>Fertilization</topic><topic>Gamete Biology</topic><topic>Growth rate</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mitochondria</topic><topic>Mitochondria - metabolism</topic><topic>Offspring</topic><topic>Oocytes</topic><topic>Oocytes - growth & development</topic><topic>Reproductive Medicine</topic><topic>Sperm Injections, Intracytoplasmic - methods</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Supplements</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kankanam Gamage, Sanath Udayanga</creatorcontrib><creatorcontrib>Hashimoto, Shu</creatorcontrib><creatorcontrib>Miyamoto, Yuki</creatorcontrib><creatorcontrib>Nakano, Tatsuya</creatorcontrib><creatorcontrib>Yamanaka, Masaya</creatorcontrib><creatorcontrib>Kitaji, Hideki</creatorcontrib><creatorcontrib>Takada, Yuki</creatorcontrib><creatorcontrib>Matsumoto, Hiroshi</creatorcontrib><creatorcontrib>Koike, Akiko</creatorcontrib><creatorcontrib>Satoh, Manabu</creatorcontrib><creatorcontrib>Ichishi, Masako</creatorcontrib><creatorcontrib>Watanabe, Masatoshi</creatorcontrib><creatorcontrib>Morimoto, Yoshiharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kankanam Gamage, Sanath Udayanga</au><au>Hashimoto, Shu</au><au>Miyamoto, Yuki</au><au>Nakano, Tatsuya</au><au>Yamanaka, Masaya</au><au>Kitaji, Hideki</au><au>Takada, Yuki</au><au>Matsumoto, Hiroshi</au><au>Koike, Akiko</au><au>Satoh, Manabu</au><au>Ichishi, Masako</au><au>Watanabe, Masatoshi</au><au>Morimoto, Yoshiharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>41</volume><issue>8</issue><spage>2065</spage><epage>2077</epage><pages>2065-2077</pages><issn>1058-0468</issn><issn>1573-7330</issn><eissn>1573-7330</eissn><abstract>Purpose
In our previous study, we confirmed that the supplementation of vitrified-warmed murine oocytes with autologous adipose stem cell (ASC)-derived mitochondria during intracytoplasmic sperm injection enhances post-fertilization developmental competence in mice. To ensure the safety of this technology, we conducted a thorough study in mice to investigate the potential presence of specific malformations in offspring developed from this approach.
Methods
A transgenerational comparative analysis was conducted on founder mice from embryos that developed after mitochondrial supplementation, and two subsequent generations. Reproductive performance, body growth rate, histopathological parameters, hematological parameters, daily activity patterns, and daily body temperature changes in male and female mice across these three generations were assessed in comparison to wild-type mice of the same age.
Results
Both male and female animals in all three generations showed comparable reproductive performance to the control group. Additionally, body growth rate by the age of 8 weeks were found to be comparable to controls across all three generations. Notably, no significant histopathological abnormalities were detected in vital organs, including the brain, heart, liver, kidneys, lungs, ovaries, and testes, in any individuals from the studied cohorts. The blood parameters were consistent with the control data. The continuous monitoring of activity and body temperature changes (both day and night) over a 1-week period revealed a pattern closely resembling that observed in the control animals.
Conclusion
Injection of ASC-mitochondria into oocytes may be a promising technique to support developmental potential without causing adverse epigenetic events in the offspring in mice. However, before considering clinical application, additional safety screening using larger animals or non-human primates is essential.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38777961</pmid><doi>10.1007/s10815-024-03137-2</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2834-2726</orcidid><orcidid>https://orcid.org/0000-0002-2198-1069</orcidid><orcidid>https://orcid.org/0000-0001-9083-1403</orcidid><orcidid>https://orcid.org/0000-0002-9423-0901</orcidid><orcidid>https://orcid.org/0000-0003-4710-3448</orcidid></addata></record> |
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| subjects | Activity patterns Adipose Tissue - cytology Animals Body temperature Comparative analysis Cryopreservation - methods Embryos Epigenetics Female Fertilization Gamete Biology Growth rate Gynecology Human Genetics Humans Male Medicine Medicine & Public Health Mice Mitochondria Mitochondria - metabolism Offspring Oocytes Oocytes - growth & development Reproductive Medicine Sperm Injections, Intracytoplasmic - methods Stem cells Stem Cells - cytology Stem Cells - metabolism Supplements |
| title | Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality |
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