p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing pro-survival mitophagy

Cancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to organelles can trigger CSC pool exhaustion; however, the underlying mechanisms are poorly understood. ZER6 is...

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Veröffentlicht in:	Oncogene 2024-06, Vol.43 (27), p.2115-2131
Hauptverfasser:	Li, Wenfang, Huang, Can, Qiu, Li, Tang, Yu, Zhang, Xia, Zhang, Lei, Zhao, Hezhao, Miyagishi, Makoto, Kasim, Vivi, Wu, Shourong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/109 13/31 13/44 13/51 14/19 38/77 38/91 631/67/1504/1885 631/80/304 64/60 96/95 Animals Apoptosis Cancer Cell Biology Cell Line, Tumor Cell Survival - genetics Disease Progression Gene Expression Regulation, Neoplastic Human Genetics Humans Internal Medicine Isoforms Medicine Medicine & Public Health Mice Mitophagy Mitophagy - genetics Molecular modelling N-Terminus Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology Organelles Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Stem cells Transcriptomics Tumor cells Tumors Zinc finger proteins
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