Glycolysis inhibition affects proliferation and cytotoxicity of Vγ9Vδ2 T cells expanded for adoptive cell therapy

Vγ9Vδ2 T cells are under investigation as alternative effector cells for adoptive cell therapy (ACT) in cancer. Despite promising in vitro results, anti-tumor efficacies in early clinical studies have been lower than expected, which could be ascribed to the complex interplay of tumor and immune cell...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2024-09, Vol.26 (9), p.1033-1045
Hauptverfasser:	Aehnlich, Pia, Santiago, Marta Velasco, Dam, Søren Helweg, Saló, Sara Fresnillo, Rahbech, Anne, Olsen, Lars Rønn, thor Straten, Per, Desler, Claus, Holmen Olofsson, Gitte
Format:	Artikel
Sprache:	eng
Schlagworte:	adoptive cell therapy Cell Line, Tumor Cell Proliferation cytotoxicity Cytotoxicity, Immunologic Glycolysis Humans Immunotherapy, Adoptive - methods Lymphocyte Activation Melanoma - immunology Melanoma - therapy metabolism Oxidative Phosphorylation Receptors, Antigen, T-Cell, gamma-delta - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Microenvironment Vγ9Vδ2 T cells γδ T cells
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