Tumor-Targeted Codelivery of CpG and siRNA by a Dual-Ligand-Functionalized Curdlan Nanoparticle

The simultaneous delivery of CpG oligonucleotide along with short interfering RNA (siRNA) has the potential to significantly boost the anticancer impact of siRNA medications. Our previous research demonstrated that Curdlan nanoparticles functionalized with adenosine are capable of selectively delive...

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Veröffentlicht in:	Biomacromolecules 2024-06, Vol.25 (6), p.3360-3372
Hauptverfasser:	Bao, Qingming, Bao, Mingming, Xiao, Hai, Ganbold, Tsogzolmaa, Han, Shuqin, Baigude, Huricha
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Animals beta-Glucans - chemistry beta-Glucans - pharmacology Cell Line, Tumor curdlan cytokines Drug Delivery Systems - methods endocytosis Ligands lungs macrophages Macrophages - drug effects Macrophages - metabolism mannose Melanoma, Experimental - drug therapy Melanoma, Experimental - pathology metastasis Mice Mice, Inbred C57BL nanoparticles Nanoparticles - chemistry neoplasms Oligodeoxyribonucleotides - administration & dosage Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - pharmacology oligonucleotides polymers RNA RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry RNA, Small Interfering - pharmacology synergism therapeutics Tumor-Associated Macrophages - drug effects
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