Effects of dapagliflozin against streptozotocin and isoproterenol-induced heart failure via investigating NLRP3 and PPAR-γ signaling

Heart failure is a condition in which the heart's one or both ventricles are unable to either receive an adequate amount of blood or eject an adequate amount of blood. Diabetes is considered one of the major risk factors for cardiovascular diseases. The current research is designed to evaluate...

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Veröffentlicht in:	Pakistan journal of pharmaceutical sciences 2024-03, Vol.37 (2), p.337
Hauptverfasser:	Ijaz, Khadija, Khan, Arif-Ullah, Kamal, Yousaf, Irshad, Nadeem
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Benzhydryl Compounds - pharmacology Cardiotonic Agents - pharmacology Diabetes Mellitus, Experimental - drug therapy Glucosides - pharmacology Heart Failure - chemically induced Heart Failure - drug therapy Heart Failure - metabolism Isoproterenol - toxicity Male Myocardium - metabolism Myocardium - pathology NLR Family, Pyrin Domain-Containing 3 Protein - metabolism PPAR gamma - metabolism Rats Rats, Wistar Signal Transduction - drug effects Sodium-Glucose Transporter 2 Inhibitors - pharmacology Streptozocin
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